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001), AT hyperreflexia (OR, 20.5; P  less then  0.001), spastic gait (OR, 225; P  less then  0.001), and gait inability (OR, 64; P  less then  0.001) were significant predictive factors. In patients with age ≥67 years, PT hyperreflexia, and/or AT hyperreflexia, the sensitivity for myelopathy diagnosis was 98%. In patients with spastic gait or gait inability, the specificity of myelopathy diagnosis was 96%. CONCLUSIONS We analyzed factors that predict latent myelopathy in patients complaining only of lower extremity symptoms. We believe a diagnostic protocol based on the predictors shown in this study would contribute to the accurate diagnosis of latent myelopathy. LEVEL OF EVIDENCE 4.STUDY DESIGN Prospective cohort study. OBJECTIVE To characterize a patient population with nonunion after acute osteoporotic vertebral fractures (OVFs) and compare the union and nonunion groups to identify risk factors for nonunion. SUMMARY OF BACKGROUND DATA While OVFs are the most common type of osteoporotic fracture, the predictive value of a clinical assessment for nonunion at 48 weeks after OVF has not been extensively studied. METHODS This prospective multicenter cohort study included female patients aged 65 to 85 years with acute one-level osteoporotic compression fractures. In the radiographic analysis, the anterior vertebral body compression percentage was measured at 0, 12, and 48 weeks. Magnetic resonance imaging (MRI) was performed at enrollment and at 48 weeks to confirm the diagnosis and union status. The patient-reported outcome measures included scores on the European Quality of Life-5 Dimensions (EQ-5D), a visual analogue scale for low back pain, and the Japanese Orthopaedic Association Back Pain Evaluation Questionnaire (JOABPEQ) at 0, 12, and 48 weeks. RESULTS In total, 166 patients completed the 12-month follow-up, 29 of whom had nonunion. Patients with nonunion at 48 weeks after OVF had lower EQ-5D and JOABPEQ walking ability, social life function, mental health, and lumbar function scores than those with union at 48 weeks after injury. The independent risk factors for nonunion after OVF in the acute phase were a diffuse low type pattern on T1-weighted MRI and diffuse low and fluid type patterns on T2-weighted MRI. The anterior vertebral body compression percentage and JOABPEQ social life function scores were independent risk factors at 12 weeks. CONCLUSION A diffuse low type pattern on T1-weighted MRI and diffuse low and fluid type patterns on T2-weighted MRI were independent risk factors for nonunion in the acute phase. Patients who have acute OVFs with these risk factors should be carefully monitored for nonunion. LEVEL OF EVIDENCE 2.Lymphovascular invasion (LVI) and perineural invasion (PNI) are 2 important pathologic parameters and need to be accurately assessed in multiple malignancies. Integrin β4, a member of the integrin family, has been reported to be positively expressed in vascular endothelia, peripheral nerves, and a collection of epithelia. However, little is known about the effectiveness of β4 immunostaining on the recognition of LVI and PNI. Herein, we explored the applicability of β4 immunostaining in stomach, thyroid, and breast cancers. Parallel immunostaining of D2-40, CD34, and S-100 was performed as controls for lymphatic endothelia, vascular endothelia, and neural fibers, respectively. The results demonstrated that β4 concurrently stained the lymphatic and vascular endothelia, and the peripheral nerves. Both LVI and PNI were clearly and accurately outlined by β4 immunostaining. β4 was also expressed in the majority of tumor cells, enabling recognition of LVI and PNI encroached by small tumor clusters. In contrast to D2-40 and CD34, β4 staining was not observed in stromal cells, and therefore it facilitated differentiation between the shrinkage cleft and LVI. According to our results, β4 staining strikingly increased the diagnostic accuracy and interobserver concordance for LVI and PNI compared with hematoxylin and eosin staining alone. Finally, the applicability of β4 was confirmed in 9 other types of malignancies, including cancers of the colon, prostate, esophagus, lung, kidney, uterus, tongue, bladder, and liver. Collectively, β4 is a reliable marker for synchronous detection and diagnosis of LVI and PNI.The combined clinical and molecular heterogeneity of prostate cancer necessitates the use of prognostic, predictive, and diagnostic biomarkers to assist the clinician with treatment selection. The pathologist plays a critical role in guiding molecular biomarker testing in prostate cancer and requires a thorough knowledge of the current testing options. In the setting of clinically localized prostate cancer, prognostic biomarkers such as Ki-67 labeling, PTEN loss or mRNA-based genomic signatures can be useful to help determine whether definitive therapy is required. In the setting of advanced disease, predictive biomarkers, such as the presence of DNA repair deficiency mediated by BRCA2 loss or mismatch repair gene defects, may suggest the utility of poly-ADP ribosylase inhibition or immune checkpoint blockade. Finally, androgen receptor-related biomarkers or diagnostic biomarkers indicating the presence of small cell neuroendocrine prostate cancer may help guide the use of androgen receptor signaling inhibitors and chemotherapy. In this review, we examine the current evidence for several prognostic, predictive and diagnostic tissue-based molecular biomarkers in prostate cancer management. For each assay, we summarize a recent survey of the International Society of Urology Pathology (ISUP) members on current testing practices and include recommendations for testing that emerged from the ISUP Working Group on Molecular Pathology of Prostate Cancer and the 2019 Consultation Conference on Molecular Pathology of Urogenital Cancers.PURPOSE To describe a heretofore unreported retinal vascular sign related to chronic retinal hypoperfusion. METHODS A case report of a 42-year-old woman who was found to have a novel pattern of retinal vascular remodeling in the setting of severe bilateral occlusive disease of the carotid and vertebral arteries. RESULTS The patient had a childhood history of nasopharyngeal carcinoma, treated with external beam radiation. At age 35, she suffered bilateral occipital infarctions. A cerebral angiogram showed complete occlusion of both common carotid arteries and complete occlusion of the proximal segments of both vertebral arteries. Seven years after her stroke, examination of her fundus revealed a remarkable pattern of vascular remodeling that involved nearly all of the major retinal arterioles in both eyes. In each vessel, a narrowed proximal segment abruptly dilated to a larger-than-normal caliber at a distance of 1 to 2 disk diameters from the optic disk. The abnormally increased caliber extended into the retinal periphery. CONCLUSION Chronic severe retinal hypoperfusion due to profound carotid occlusive disease can lead to adaptive remodeling of the retinal vasculature in a pattern that closely resembles the iconic image of a pirate's peg leg.OBJECTIVES Expansion of the scopes of practice of allied health practitioners has the potential to improve the efficiency and cost-effectiveness of healthcare, given the identified shortages in medical personnel. Despite numerous examples in other allied health disciplines, this has yet to be applied to pediatric Audiology. This study aimed to investigate the effectiveness and safety of using audiologists with advanced training to independently triage children referred to otolaryngology (ORL) services, and compare the subsequent use of specialist resources, and postoperative grommet care to a standard medical ORL service. DESIGN One hundred twenty children consecutively referred to a large ORL outpatient service in Queensland, Australia, for middle ear and hearing concerns were prospectively allocated to either the ORL service or Advanced Audiology-led service. Demographic and clinical data were extracted from electronic medical records and compared between the two services. Clinical incidents and adverse eveproves the effective use of specialist resource compared with the standard medical ORL service.BACKGROUND Interscalene brachial plexus block, the pain relief standard for shoulder surgery, is an invasive technique associated with important complications. The subomohyoid anterior suprascapular block is a potential alternative, but evidence of its comparative analgesic effect is sparse. The authors tested the hypothesis that anterior suprascapular block is noninferior to interscalene block for improving pain control after shoulder surgery. As a secondary objective, the authors evaluated the success of superior trunk (C5-C6 dermatomes) block with suprascapular block. METHODS In this multicenter double-blind noninferiority randomized trial, 140 patients undergoing shoulder surgery were randomized to either interscalene or anterior suprascapular block with 15 ml of ropivacaine 0.5% and epinephrine. The primary outcome was area under the curve of postoperative visual analog scale pain scores during the first 24 h postoperatively. The 90% CI for the difference (interscalene-suprascapular) was compared againsthese findings suggest that the suprascapular block consistently blocks the superior trunk and qualify it as an effective interscalene block alternative.WHAT WE ALREADY KNOW ABOUT THIS TOPIC Accurate stimulating electrode placement is essential for clinically effective subthalamic nucleus brain stimulation in patients with Parkinson's diseaseGeneral anesthetics-induced changes of electrical oscillations in the basal ganglia may render the identification of the stimulation targets difficultThe effects of sevoflurane-based general anesthesia on the electrophysiologic properties of subthalamic neurons, electrode placement efficacy, and long-term clinical outcomes in Parkinson's disease have not been previously reported WHAT THIS ARTICLE TELLS US THAT IS NEW When compared to local anesthesia, sevoflurane-based general anesthesia decreased beta-frequency oscillations and induced coherent lower frequency oscillations in the subthalamic nucleus of patients with Parkinson's disease undergoing electrode placement for deep brain stimulationThese sevoflurane-induced changes in electrical activity patterns did not reduce electrode placement accuracy or clinical outcomeThons suggest that microelectrode-guided deep brain stimulation under sevoflurane anesthesia is a feasible clinical option.WHAT WE ALREADY KNOW ABOUT THIS TOPIC Opioid overdose produces a rapid and profound depression of breathing, which, if not corrected, leads to a terminal hypoxic cardiac arrestSevere acute hypoxemia produces a rapid inhibition of respiratory neuronal activity through a nonopioid mechanism WHAT THIS ARTICLE TELLS US THAT IS NEW The level of hypoxemia reached during fentanyl-induced apnea in unsedated rats affected their ability to "autoresuscitate" and to respond to naloxoneFentanyl-induced apnea in urethane-anesthetized rats was not associated with spontaneous recovery when PaO2 decreased below approximately 16 mmHg during apnea and could not be reversed with naloxone BACKGROUND As severe acute hypoxemia produces a rapid inhibition of the respiratory neuronal activity through a nonopioid mechanism, we have investigated in adult rats the effects of hypoxemia after fentanyl overdose-induced apnea on (1) autoresuscitation and (2) the antidotal effects of naloxone. Mito-TEMPO METHODS In nonsedated rats, the breath-by-breath ventilatory and pulmonary gas exchange response to fentanyl overdose (300 µg · kg · min iv in 1 min) was determined in an open flow plethysmograph.