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Economically, emotionally, socially, physically and practically, grandmother kinship carers are unsupported and undervalued. We need a social, economic and cultural shift around the value of care and a redistribution of care work across genders. The situations of grandmother kinship carers need to be part of this shift, so that grandmothers who care for their grandchildren are no longer penalized, and all kinship carers are properly supported and valued.This response to Campbell et al. makes three points. First, the commitment to "know more" must examine the full ecology of relationship violence and sexual misconduct (RVSM); that knowledge is essential for creating multilevel prevention strategies. Second, a full realization of an intersectional perspective requires attention to a broader range of power-based harms, forging institutional links between RVSM prevention and work on diversity, equity, and inclusion. Third, while support for survivors is certainly vital, most people who experience harm do not report it, and so an ambitious approach to prevention is vital to building communities in which everyone can thrive.Understanding the spatial dynamics of animal movement is an essential component of maintaining ecological connectivity, conserving key habitats, and mitigating the impacts of anthropogenic disturbance. Altered movement and migratory patterns are often an early warning sign of the effects of environmental disturbance, and a precursor to population declines. Here, we present a hierarchical Bayesian framework based on Gaussian processes for analysing the spatial characteristics of animal movement. At the heart of our approach is a novel covariance kernel that links the spatially varying parameters of a continuous-time velocity model with GPS locations from multiple individuals. We demonstrate the effectiveness of our framework by first applying it to a synthetic data set and then by analysing telemetry data from the Serengeti wildebeest migration. Through application of our approach, we are able to identify the key pathways of the wildebeest migration as well as revealing the impacts of environmental features on movement behaviour.Although recent decades have been marked by tremendous strides in addressing relationship violence and sexual misconduct at institutions of higher education across the country, there still exists a range of degree and meaningfulness of these changes. A key question raised by Campbell et al. in the discussion of the model developed at Michigan State University (MSU) is how to align institutional commitment with actions, as well as engage in "meaningful" change. Three aspects of the MSU model that stand out as especially critical for other institutions to consider include working toward culture change, engaging the larger campus community, and conducting an ongoing evaluation.

The aim was to systematically review the effectiveness and safety of telemedicine combined with usual care (in-person visits) compared to usual care for the therapeutic management and follow-up assessment of neurological diseases.

The electronic databases MEDLINE, Embase, Web of Science and Cochrane Central Register of Controlled Trials were searched (June 2021). Randomized controlled trials (RCTs) on patients of any age with neurological diseases were considered. Two reviewers screened and abstracted data in duplicate and independently and assessed risk of bias using the Cochrane risk-of-bias tool for randomized trials (RoB 2). When possible, pooled effect estimates were calculated.

Of a total of 3018 records initially retrieved, 25 RCTs (n=2335) were included 11 (n=804) on stroke, four (n=520) on Parkinson's disease, three (n=110) on multiple sclerosis, two (n=320) on epilepsy, one (n=63) on dementia, one (n=23) on spina bifida, one (n=40) on migraine, one (n=22) on cerebral palsy and one (n=433) on brain damage. Types of telemedicine assessed were online visits (11 studies), tele-rehabilitation (seven studies), telephone calls (three), smartphone apps (two) and online computer software (two). The evidence was quite limited except for stroke. Compared to usual care alone, telemedicine plus usual care was found to improve depressive symptoms, functional status, motor function, executive function, generic quality of life, healthcare utilization and healthy lifestyle in patients in post-stroke follow-up.

Well-designed and executed RCTs are needed to confirm our findings on stroke and to have more scientific evidence available for the other neurological diseases.

Well-designed and executed RCTs are needed to confirm our findings on stroke and to have more scientific evidence available for the other neurological diseases.Piper longum (family Piperaceae), commonly known as "long-pepper" or "Pippali" grows as a perennial shrub or as an herbaceous vine. It is native to the Indo-Malaya region and widely distributed in the tropical and subtropical world including the Indian subcontinent, Sri Lanka, Middle-East, and America. The fruits are mostly used as culinary spice and preservatives and are also a potent remedy in various traditional medicinal systems against bronchitis, cough, cold, snakebite, and scorpion-sting and are also used as a contraceptive. Various bioactive-phytochemicals including alkaloids, flavonoids, esters, and steroids were identified from the plant extracts and essential oils from the roots and fruits were reported as antimicrobial, antiparasitic, anthelminthic, mosquito-larvicidal, antiinflammatory, analgesic, antioxidant, anticancer, neuro-pharmacological, antihyperglycaemic, hepato-protective, antihyperlipidaemic, antiangiogenic, immunomodulatory, antiarthritic, antiulcer, antiasthmatic, cardioprotective, and anti-snake-venom agents. Many of its pharmacological properties were attributed to its antioxidative and antiinflammatory effects and its ability to modulate a number of signalling pathways and enzymes. This review comprehensively encompasses information on habit, distribution, ethnobotany, phytochemistry, and pharmacology of P. longum in relation to its medicinal importance and health benefits to validate the traditional claims supported by specific scientific experiments. In addition, it also discusses the safety and toxicity studies, application of green synthesis and nanotechnology as well as clinical trials performed with the plant also elucidating research gaps and future perspectives of its multifaceted uses.A series of experiments in stationary and moving passenger railcars was conducted to measure the removal rates of particles in the size ranges of SARS-CoV-2 viral aerosols, and the air changes per hour provided by the existing and modified air handling systems. The effect of ventilation and air filtration systems on removal rates and their effects on estimated probability (i.e., risk) of infection was evaluated in a range of representative conditions (1) for two different ratios of recirculated air (RA) to outdoor air (OA) (9010 RAOA and 6733 RAOA); (2) using minimum efficiency reporting value (MERV) filters with standard (MERV-8) and increased (MERV-13) filtration ratings; and (3) in the presence and absence of a portable high-efficiency particulate-air (HEPA) room air purifier system operated at clean air delivery rate (CADR) of 150 and 550 cfm. The higher-efficiency MERV-13 filters significantly increased particle removal rates on average by 3.8 to 8.4 hr-1 across particle sizes ranging from 0.3 to 10 µm (p  less then  0.01) compared to MERV-8 filters. The different RAOA ratios and the use of a portable HEPA air purifier system had little effect on particle removal rates. MERV-13 filters reduced the estimated probability of infection by 42% compared to the MERV-8 filter. The use of a HEPA-air purifier with a MERV-13 filter causes a 50% reduction in the estimated probability of infection. this website Upgrading the efficiency of HVAC filters from MERV-8 to MERV-13 in public transit vehicles is the most effective exposure control method resulting in a clear reduction in the removal rates of aerosol particles and the estimated probability of infection.There is an unmet clinical need to end the COVID-19 pandemic. In the past 2 years, the SARS-CoV-2 continued to evolve and poses a critical challenge to the efficacy of the vaccine and neutralizing antibody therapies. The fifth wave of the pandemic is driven by the Omicron variants, due to their ability to evade prior immunity and their resistance to therapeutic antibodies. The report by Zhang et al in the current issue of EMBO Molecular Medicine shows that the engineered decoy ACE2 can reduce lung injury and improve survival in K18-hACE2 transgenic mice inoculated with a lethal dose of the SARS-CoV-2 and potentially targets the Omicron variant.Although plenty of clinical trials have confirmed the efficacy and safety of integrated traditional Chinese and Western medicine (ITCWM) against COVID-19, the role of ITCWM remains controversial. So we conducted a systematic review and meta-analysis of published studies in eight major databases that report the outcomes of interest in COVID-19 patients receiving ITCWM. RevMan5.4 software was used for meta-analysis, while the quality of RCTs was assessed by the Cochrane risk of bias tool and the retrospective studies were assessed by Newcastle-Ottawa Scale. Eventually, a total of 53 studies with 5425 COVID-19 patients was identified. The meta-analysis results showed that ITCWM was significantly better than western medicine treatment (WMT) alone in the percentage of cases changing to severe/critical [RR = 0.40, 95%CI (0.33, 0.49), p  less then  .00001, I2 = 10%], overall clinical effectiveness [RR = 1.26, 95% CI (1.18, 1.35), p  less then  .00001, I2 = 50%], time to defervescencer [MD = -1.45, 95% CI (-1.82, -1.l efficacy and safety benefit in COVID-19 patients treated with ITCWM. In spite of some limitations, the rapidly developing global pandemic warrants further high-quality and multicenter clinical studies to confirm the contribution of ITCWM.

To explore the perceived need and enthusiasm for over the counter (OTC) progestogen-only pills (POP).

A web-based survey of 1000 sexually active women (16-45) and 100 pharmacists in Germany, Italy and Spain.

Despite not wanting to conceive, 5-6% of women in each country were not using contraception and 8-20% were using methods less effective than condoms. At least 74% of respondents felt knowledgeable about the different contraceptives available but at least 1/3 had experienced difficulty accessing oral contraceptive (OCs) in the past two years. The cost of contraceptives, the need to see a doctor and long waits for appointments were cited as barriers for not using OCs. The majority agreed they would discuss with their doctor the decision to buy the POP, consult about side effects and other reproductive health issues. Over 2/3 of pharmacists in each country would be very, or fairly, likely to recommend the POP, agreeing that the benefits included improved access for women, and offered them more independence.

Asked directly, women in Germany, Spain and Italy currently using contraception are positive about a POP OTC. Pharmacists are also positive, with the overwhelming majority in favour of providing POPs.

Asked directly, women in Germany, Spain and Italy currently using contraception are positive about a POP OTC. Pharmacists are also positive, with the overwhelming majority in favour of providing POPs.