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She showed dramatic recovery (NIHSS score of 5 after 48 h) and was discharged on day 7 with a modified Rankin Score of 1. To our knowledge, our patient is the second oldest documented patient who successfully underwent bridging therapy for stroke.Recombinant tissue plasminogen activator (rtPA) may be considered in acute ischemic strokes (AIS) occurring in pregnancy. This recommendation is based on case reports which had demonstrated the efficiency and safety of rtPA in early pregnancy. However, most of the pregnancy-related strokes occur in the peripartum period. There is a paucity of literature on the management of AIS in this clinically relevant period of pregnancy; with only 2 case reports describing the use of IV rt-PA in the last trimester. Here, we report a case of AIS in a full-term pregnancy treated successfully with intravenous rt-PA. The patient went on to have an uncomplicated vaginal delivery after 72 h post thrombolysis. To the best of our knowledge, this is only the third such case in the English literature.Due to the rapid development of human-computer interaction, affective computing has attracted more and more attention in recent years. In emotion recognition, Electroencephalogram (EEG) signals are easier to be recorded than other physiological experiments and are not easily camouflaged. Because of the high dimensional nature of EEG data and the diversity of human emotions, it is difficult to extract effective EEG features and recognize the emotion patterns. This paper proposes a multi-feature deep forest (MFDF) model to identify human emotions. The EEG signals are firstly divided into several EEG frequency bands and then extract the power spectral density (PSD) and differential entropy (DE) from each frequency band and the original signal as features. A five-class emotion model is used to mark five emotions, including neutral, angry, sad, happy, and pleasant. With either original features or dimension reduced features as input, the deep forest is constructed to classify the five emotions. These experiments are conducted on a public dataset for emotion analysis using physiological signals (DEAP). The experimental results are compared with traditional classifiers, including K Nearest Neighbors (KNN), Random Forest (RF), and Support Vector Machine (SVM). The MFDF achieves the average recognition accuracy of 71.05%, which is 3.40%, 8.54%, and 19.53% higher than RF, KNN, and SVM, respectively. Besides, the accuracies with the input of features after dimension reduction and raw EEG signal are only 51.30 and 26.71%, respectively. The result of this study shows that the method can effectively contribute to EEG-based emotion classification tasks.Topological data analyses are widely used for describing and conceptualizing large volumes of neurobiological data, e.g., for quantifying spiking outputs of large neuronal ensembles and thus understanding the functions of the corresponding networks. Below we discuss an approach in which convergent topological analyses produce insights into how information may be processed in mammalian hippocampus-a brain part that plays a key role in learning and memory. The resulting functional model provides a unifying framework for integrating spiking data at different timescales and following the course of spatial learning at different levels of spatiotemporal granularity. This approach allows accounting for contributions from various physiological phenomena into spatial cognition-the neuronal spiking statistics, the effects of spiking synchronization by different brain waves, the roles played by synaptic efficacies and so forth. In particular, it is possible to demonstrate that networks with plastic and transient synaptic architectures can encode stable cognitive maps, revealing the characteristic timescales of memory processing.Instrumented assessments of quiet-stance postural control typically involve recording and analyzing of body sway signal, most often the center of pressure (CoP) movement. It has been recently suggested that transient characteristics of body sway may offer additional information regarding postural control. In this study, we explored the relationship between whole-trial estimates of body sway (CoP velocity, amplitude, and frequency) and corresponding transient behavior indexes, as well as the effects of leg preference. A total of 705 healthy young athletes performed 30 s single-leg body sway trials for both legs. It was found that the transient characteristics of the body sway (expressed as relative differences between individual time intervals within the trial) are in negligible or weak correlation (r ≤ 0.26) with the corresponding variables, averaged across the whole trial. All CoP variables showed transient characteristics, reflected in statistically significant decrease (CoP velocity and amplitude) or increase (CoP frequency) throughout the trial. The preferred leg showed smaller body sway; however, the effect sizes were very small. Moreover, differences between the legs were also noted in terms of transient characteristics of body sway. In particular, the preferred leg showed earlier reduction in anterior-posterior body sway and larger reduction in medial-lateral body sway. Further studies should focus on examining the clinical utility of indexes of transient behavior of body sway, for instance, their sensitivity to aging-related changes and risk of falling.Cognitive fatigue is a problem for the safety of critical systems (e.g., aircraft) as it can lead to accidents, especially during unexpected events. In order to determine the extent to which it disrupts adaptive capabilities, we evaluated its effect on online and anticipatory control. Despite numerous studies conducted to determine its effects, the exact mechanism(s) affected by fatigue remains to be clarified. In this study, we used distribution and electromyographic analysis to assess whether cognitive fatigue increases the capture of the incorrect automatic response or if it impairs its suppression (online control), and whether the conflict adaptation effect is reduced (anticipatory control). To this end, we evaluated the evolution of the performance over time during the Simon task, a classic conflict task that elicits incorrect automatic responses. see more To accentuate the presence of fatigue during the Simon task, two groups previously performed a dual-task with two different cognitive load levels to create two different levels of fatigue. The results revealed that time on task impaired online control by disrupting the capacity to suppress the incorrect response but leaving unaffected the expression of the automatic response. Furthermore, participants emphasized speed rather than accuracy with time on task, with in addition more fast guesses, suggesting that they opted for a less effortful response strategy. As the implementation of the suppression mechanism requires cognitive effort, the conjunction of these results suggests that the deficits observed may be due to disengagement of effort over time rather than reflecting an incapacity to make an effort.A lot of research has been done on the detection of mental workload (MWL) using various bio-signals. Recently, deep learning has allowed for novel methods and results. A plethora of measurement modalities have proven to be valuable in this task, yet studies currently often only use a single modality to classify MWL. The goal of this research was to classify perceived mental workload (PMWL) using a deep neural network (DNN) that flexibly makes use of multiple modalities, in order to allow for feature sharing between modalities. To achieve this goal, an experiment was conducted in which MWL was simulated with the help of verbal logic puzzles. The puzzles came in five levels of difficulty and were presented in a random order. Participants had 1 h to solve as many puzzles as they could. Between puzzles, they gave a difficulty rating between 1 and 7, seven being the highest difficulty. Galvanic skin response, photoplethysmograms, functional near-infrared spectrograms and eye movements were collected simultaneously using LabStreamingLayer (LSL). Marker information from the puzzles was also streamed on LSL. We designed and evaluated a novel intermediate fusion multimodal DNN for the classification of PMWL using the aforementioned four modalities. Two main criteria that guided the design and implementation of our DNN are modularity and generalisability. We were able to classify PMWL within-level accurate (0.985 levels) on a seven-level workload scale using the aforementioned modalities. The model architecture allows for easy addition and removal of modalities without major structural implications because of the modular nature of the design. Furthermore, we showed that our neural network performed better when using multiple modalities, as opposed to a single modality. The dataset and code used in this paper are openly available.Gender roles are anti-dichotomous and malleable social constructs that should theoretically be constructed independently from biological sex. However, it is unclear whether and how the factor of sex is related to neural mechanisms involved in social constructions of gender roles. Thus, the present study aimed to investigate sex specificity in gender role constructions and the corresponding underlying neural mechanisms. We measured gender role orientation using the Bem Sex-Role Inventory, used a voxel-based global brain connectivity method based on resting-state functional magnetic resonance imaging to characterize the within-network connectivity in the brain reward network, and analyzed how the integration of the reward network is related to gender role scores between sex groups. An omnibus analysis of voxel-wise global brain connectivity values within a two-level linear mixed model revealed that in female participants, femininity scores were positively associated with integration in the posterior orbitofrontal cortex and subcallosal cortex, whereas masculinity scores were positively associated with integration in the frontal pole. By contrast, in male participants, masculinity was negatively correlated with integration in the nucleus accumbens and subcallosal cortex. For the first time, the present study revealed the sex-specific neural mechanisms underlying distinct gender roles, which elucidates the process of gender construction from the perspective of the interaction between reward sensitivity and social reinforcement.To identify the common and specific structural basis of bipolar depression (BD) and unipolar depression (UD) is crucial for clinical diagnosis. In this study, a total of 85 participants, including 22 BD patients, 36 UD patients, and 27 healthy controls, were enrolled. A voxel-based morphology method was used to identify the common and specific changes of the gray matter volume (GMV) to determine the structural basis. Significant differences in GMV were found among the three groups. Compared with healthy controls, UD patients showed decreased GMV in the orbital part of the left inferior frontal gyrus, whereas BD patients showed decreased GMV in the orbital part of the left middle frontal gyrus. Compared with BD, UD patients have increased GMV in the left supramarginal gyrus and middle temporal gyrus. Our results revealed different structural changes in UD and BD patients suggesting BD and UD have different neurophysiological underpinnings. Our study contributes toward the biological determination of morphometric changes, which could help to discriminate between UD and BD.