Stokholmflanagan6087

Past research has shown that how people rate their physical attractiveness is only moderately correlated with how they are rated by others, suggesting that at least some people have little insight into their true level of attractiveness. The present research tests the hypothesis that unattractive people are not aware of their unattractiveness. In fact, six studies (overall N = 1,180) showed that unattractive participants considerably overestimated their attractiveness compared to ratings by strangers. In contrast, attractive participants were more accurate. If anything, they underestimated their attractiveness. It was also examined why unattractive people overestimate their attractiveness. As expected, unattractive participants differentiated less between attractive and unattractive stimulus persons than did attractive participants. They were also more likely than attractive participants to select unattractive stimulus persons to compare themselves to. However, these tendencies did not account for why unattractive participants overestimated their attractiveness, nor did affirming participant's self-worth. Limitations and avenues for future research are discussed. © 2020 The Authors. Scandinavian Journal of Psychology published by Scandinavian Psychological Associations and John Wiley & Sons Ltd.Micro-transplantation (MST) by chemotherapy combined with granulocyte colony-stimulating factor-mobilized peripheral blood stem cell (GPBSC) infusion from HLA partial matched related donor has shown some encouraging effective therapy for acute myeloid leukemia (AML). However, the outcome of human leukocyte antigen (HLA) fully mismatched unrelated donor-derived MST in such patients is still unknown. In the present study, we compared the efficacy of human leukocyte antigen (HLA) fully mismatched unrelated donor-derived MST and partly matched related donor-derived MST in AML of 126 patients from 2 centers in China, These patients, aged 16 to 65 years, were given 3 or 4 courses of MST, which consisted of a high dosage cytarabine followed by GPBSC from unrelated donor or related donor. There was a statistically significant difference in 3-year leukemia-free survival and 3-year overall survival between the unrelated and the related group. The non-treatment-related mortality rates of patients, and other adverse complications, were no different in two groups. In conclusion, unrelated donor-derived MST is believed to be a safe treatment, with efficacy similar to or higher than related donor-derived MST. This result provides support for the potential of MST for expanding the donor selection. However, the specific mechanism of action needs further study. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.Mitochondrial dysfunction has a recognised role in the progression of Alzheimer's disease (AD) pathophysiology. Cerebral perfusion becomes increasingly inefficient throughout ageing, leading to unbalanced mitochondrial dynamics. This effect is exaggerated by amyloid β (Aβ) and phosphorylated tau, two hallmark proteins of AD pathology. A neuroprotective role for the adipose-derived hormone, leptin, has been demonstrated in neuronal cells. However, its effects with relation to mitochondrial function in AD remain largely unknown. To address this question, we have used both a glucose-serum deprived (CGSD) model of ischaemic stroke in SH-SY5Y cells and a Aβ1-42 -treatment model of AD in differentiated hippocampal cells. Using a combination of JC-1 and MitoRed staining techniques, we show that leptin prevents depolarisation of the mitochondrial membrane and excessive mitochondrial fragmentation induced by both CGSD and Aβ1-42 . Thereafter, we used ELISAs and a number of activity assays to reveal the biochemical underpinnings of these processes. Specifically, leptin was seen to inhibit upregulation of the mitochondrial fission protein Fis1 and downregulation of the mitochondrial fusion protein, Mfn2. Furthermore, leptin was seen to upregulate the expression and activity of the antioxidant enzyme, monoamine oxidase B. Herein we provide the first demonstration that leptin is sufficient to protect against aberrant mitochondrial dynamics and resulting loss of function induced by both CGSD and Aβ1-42 . We conclude that the established neuroprotective actions of leptin may be facilitated through regulation of mitochondrial dynamics. This article is protected by copyright. U73122 inhibitor All rights reserved.Phenology is an important indicator of environmental variation and climate change impacts on tree responses. In conifers, monitoring phenology of photosynthesis through remote sensing has been unreliable, because needle foliage varies little throughout the year. This is challenging for modelling ecosystem carbon uptake and monitoring phenology for enhanced breeding (genomic selection) and forest health. Here, we demonstrate that drone-based carotenoid-sensitive spectral indices, such as the Chl/carotenoid index (CCI), can be used to track phenology in conifers by taking advantage of the close relationship between seasonally changing carotenoid levels and the variation of photosynthetic activity. Physiological ground measurements, including photosynthetic pigments and maximum quantum yield of Chl fluorescence, indicated that CCI tracked the variation of photosynthetic activity better than other vegetation indices for 30 white spruce seedlings measured over 1 yr. A machine-learning approach, using CCI derived from drone-based multispectral imagery, was used to model phenology of photosynthesis for the entire pedigree population (6000 seedlings). This high-throughput drone-based phenotyping approach is suitable for studying climate change impacts and environmental variation on the physiological status of thousands of field-grown conifers at unprecedented speed and scale. © 2020 The Authors New Phytologist © 2020 New Phytologist Trust.BACKGROUND Postoperative pancreatic fistula is one of the most frequent and potentially life-threatening complications following pancreatic resections. Fibrin sealants have been used in some centers to reduce postoperative pancreatic fistula. However, the use of fibrin sealants during pancreatic surgery is controversial. This is an update of a Cochrane Review last published in 2018. OBJECTIVES To assess the safety, effectiveness, and potential adverse effects of fibrin sealants for the prevention of postoperative pancreatic fistula following pancreatic surgery. SEARCH METHODS We searched trial registers and the following biomedical databases the Cochrane Library (2019, Issue 2), MEDLINE (1946 to 13 March2019), Embase (1980 to 11 March 2019), Science Citation Index Expanded (1900 to 13 March 2019), and Chinese Biomedical Literature Database (CBM) (1978 to 13 March 2019). SELECTION CRITERIA We included all randomised controlled trials that compared fibrin sealant (fibrin glue or fibrin sealant patch) versus control (no fibrin sealant or placebo) in people undergoing pancreatic surgery.