Jessenleblanc0922

Moreover, the dual-scale vaccine is synergized with an immune checkpoint inhibitor to inhibit tumor growth in tumor-bearing mice. The findings suggest that the MSR is a novel platform for delivering nanoparticle vaccines for the enhancement of cancer immunotherapy. Ultrasonic bioreactors have been used for in vitro experimentation to study cellular responses to low-intensity pulsed ultrasound. The presence of an air interface in these bioreactors contributes to variability in the acoustic pressure field, reducing experimental reproducibility. A multiphysics finite element model was developed to simulate the acoustic field in an in-dish ultrasonic bioreactor, where the transducer is immersed in culture medium above the dish surface, and the effects of replacing air below the dish in the bioreactor with a water layer bounded by an acoustic absorbent layer were evaluated. Frequency domain simulations showed that the spatially-averaged pressure at the dish surface alternated between a minimum and maximum level as the distance between the dish and transducer increased. The ratio of the maximum to minimum level was 6.5-fold when the air interface was present, and this ratio dropped to 1.8-fold with replacement of the air interface. However, radial pressure variability was present with or without the air interface in the bioreactor model. Time-dependent simulations showed that the increase in acoustic pressure to a maximum level after US signal activation and the pressure drop after signal cessation were faster when the water-coupled non-reflective layer was used to replace the air layer below the dish, generating a pressure pattern that more closely followed the applied pulsed ultrasound signal due to reduced wave reflection and interference. Overall, this work showed that having water rather than air in contact with the lower dish surface when paired with an acoustic absorbent layer resulted in a less variable pressure field, providing an improved bioreactor design for in vitro experiments. This article explores linkages between organisation-specific cultural narratives and gender-equality programme planning through the lens of the 'historicity' concept. The article argues that to fully understand problem definitions, programme design and organisational change processes related to gender equality, scholars and practitioners cannot focus one-sidedly on expected outcomes and effects; we must also factor in cultural narratives, because gender equality actors never arrive at their work as 'tabulae rasae'. A community of actors always draws on shared dispositions that give sense, direction and shape to their anticipations of the future hereby guiding their actions in the present. Based on an ethnography of a multinational engineering company, the article shows how cultural narratives may serve in different ways as support factors for gender equality programme planning and implementation, if they are actively but mindfully engaged. This mindfulness is important as positive cultural narratives may entail problematic gender dimensions. https://www.selleckchem.com/products/epoxomicin-bu-4061t.html On the other hand, negative cultural narratives may entail important learning outcomes that may benefit future gender equality initiatives. The analysis further points to the centrality of strategic communication, leadership commitment and comprehensive evaluation in order to mobilise the potential of cultural narratives as support factors to gender equality work. Finally, this article offers a rich example to scholars and practitioners of how to employ cultural analysis in relation to gender equality activities, and demonstrates the value of the insights produced by this analysis for the case company and its gender equality programme. Highway-rail grade crossings (HRGCs) are where a roadway and railway intersect at the same level. Safety at HRGCs has been identified as a high-priority concern among transportation agencies, but there has been little research on the effects of HRGC geometric parameters on their safety performance. This paper evaluates the effects of HRGC geometric parameters on crash occurrence and severity likelihoods. The competing risk algorithm is selected to simultaneously analyze crash occurrence and severities. Four main HRGC geometric factors, along with other contributors, are investigated at 3,194 public HRGCs in North Dakota. This study focuses primarily on four geometric features of an HRGC (1) acute crossing angle, (2) number of tracks (indicator of crossing width), (3) the roadway distance between the HRGC and the signalized intersection, and (4) number of highway lanes. Distance to the nearest roadway intersections and highway-railway crossing angles are map-based calculations drawn from geographic information systems (GIS). The findings are (1) all contributors tested in this study, including highway characteristics, traffic exposures from both railway and highway, and the four geometric features, significantly affect at least one crash severity level; (2) all contributors significantly impact crash frequency except for the distance between crossings and the nearest roadway intersection; and (3) geometric parameters' long-term effects on cumulative probability of crash severity and occurrence over 30 years is also evaluated. Crossings with three main tracks contribute the highest long-term crash probabilities. Transarterial chemoembolization (TACE) is the preferred treatment for patients with unresectable intermediate stage hepatocellular carcinoma, however currently the development of embolic agents for TACE lacks in vitro models that closely represent the sophisticated features of the organ and the vascular systems therein. In this study, we presented a new strategy using an ex vivo liver model to provide a translucent template for evaluating embolic agents of TACE. The ex vivo liver model was developed through decellularizion of rat liver organs with preserved liver-specific vasculatures and improved transmittance of the whole liver up to 23% at 550 nm. Using this model, we investigated the embolization performances of both liquid and particle-based embolic agents, including penetration depth, embolization end-points, injection pressure and spatial distribution dynamics. We found that the embolization endpoint of liquid embolic agent such as ethiodised oil was strongly dependent on the injection pressure, and the pressure quickly built up when reaching the capillary endings, which could cause embolic agent leaking and potential tissue damages.