Vickhart5692
Though human papillomavirus (HPV)-related lesions in the neovagina of transgender women have been well documented, information around high risk HPV in the neovagina have been very limited. The objective of this study was to determine hrHPV DNA detection rate in the neovagina of transgender women.
Neovaginal and anal swab were collected in liquid-based cytology fluid from transgender women visiting Gender-Health Clinic and Tangerine Community Health Clinic in Bangkok, Thailand. Sunitinib mw Samples were processed by for hrHPV DNA (reported as subtype 16, 18 or pooled result of 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66) by automated real-time PCR and for neovaginal cytology according to the Bethesda system. Demographic data and sexual history were obtained, physical examination was conducted. HIV status was obtained from existing medical records.
Samples were collected from 57 transgender women (mean age 30.4 years, [IQR = 8]). From 35 valid out of 57 neovaginal samples, 8 (20%) tested positive for hrHPV DNA. From 30 valid out of 57 anal samples, 6 (19.4%) tested positive for hrHPV DNA. HIV status was known for 52 transgender women, 1 of which were HIV-infected; neovaginal hrHPV was invalid in that patient.
One out of five transgender women visiting sexual health clinics in Bangkok was found to have hrHPV DNA in neovaginal and anal compartments. Studies are needed to look at incidence and persistence of hrHPV infection to inform ano-genital precancerous and cancerous screening programs for transgender women.
One out of five transgender women visiting sexual health clinics in Bangkok was found to have hrHPV DNA in neovaginal and anal compartments. Studies are needed to look at incidence and persistence of hrHPV infection to inform ano-genital precancerous and cancerous screening programs for transgender women.
The reverse algorithm for syphilis diagnosis consists of a treponemal antibody screening immunoassay followed by confirmatory non-treponemal antibody testing. It is increasingly used in the US despite studies suggesting limited cost-effectiveness in high-prevalence groups.
In this retrospective cross-sectional study, we included men who have sex with men (MSM) tested with the reverse algorithm in an Alabama HIV clinic between March 2015 and February 2017. Trepsure enzyme immunoassay (EIA) was used for the initial screen, followed by reflex non-treponemal reactive plasma reagin (RPR) testing of specimens with positive results. Sociodemographic and clinical data were extracted from the electronic medical record and stratified according to EIA screen positivity. Quantitative EIA antibody index values were collected to assess test performance at various thresholds.
Among 1693 men tested for syphilis with the reverse algorithm in HIV clinic, 808 (48%) had a positive initial EIA screen. A majority (53%) of men with subsequent RPR testing had a non-reactive RPR (EIA+/RPR-) and 19% (19/98) of these EIA+/RPR- samples tested had negative confirmatory TPPA testing. Analysis of quantitative EIA index values using a receiver operating characteristics curve suggested that a threshold >8 (rather the current threshold of antibody index 1.2) improved the performance of the test.
Among MSM tested in HIV clinic, the syphilis reverse algorithm was inefficient due to high rates of prior syphilis and false positive EIA screening. Frequent syphilis screening in high prevalence populations is an important part of the US epidemic response and the traditional algorithm is preferred.
Among MSM tested in HIV clinic, the syphilis reverse algorithm was inefficient due to high rates of prior syphilis and false positive EIA screening. Frequent syphilis screening in high prevalence populations is an important part of the US epidemic response and the traditional algorithm is preferred.
HIV pre-exposure prophylaxis (PrEP) has helped reduce new HIV infections. However bacterial sexually transmitted infections (STIs) have increased amongst PrEP users. We examined PrEP knowledge, access and risk perceptions in an age of antimicrobial resistance (AMR).
An online anonymous survey was distributed to all cisgender men/trans-persons-who-have-sex-with-men (MSM/TPSM) attending a sexual health clinic in Bristol, UK (October 2018 - November 2019). Interviews with a sample identified at increased risk of HIV were analysed thematically and integrated with survey data.
Five hundred and seventy-eight (95%) of 617 MSM/TPSM survey respondents were HIV-negative/unknown, of these 202 (34.9%) had ever used PrEP. Interviewees (n=24) reported widespread awareness of and enthusiasm for PrEP. Among non-users, 39% (146/376) were unaware how to access PrEP and 27% (103/376) could not access PrEP through the national 'Impact' trial of whom 79% (81/103) were eligible. PrEP was described as 'life-changing', but expn-making.
Human immunodeficiency virus, Neisseria gonorrhoeae/Chlamydia trachomatis, and syphilis testing decreased with the implementation of mitigation measures for SARS-CoV-2 and did not return to 2019 levels by September 2020. However, primary and secondary syphilis diagnoses increased during mitigation measures. Sexual health services are essential during the SARS-CoV-2 pandemic.
Human immunodeficiency virus, Neisseria gonorrhoeae/Chlamydia trachomatis, and syphilis testing decreased with the implementation of mitigation measures for SARS-CoV-2 and did not return to 2019 levels by September 2020. However, primary and secondary syphilis diagnoses increased during mitigation measures. Sexual health services are essential during the SARS-CoV-2 pandemic.
During the initial height of COVID-19 in New York State excluding New York City in March 2020, reports of sexually transmitted infections declined. Prediction models developed to estimate the incidence of early syphilis and gonorrhea during the COVID-19 pandemic were used to study impact on STI diagnoses/reporting and inform sexual health program planning.
During the initial height of COVID-19 in New York State excluding New York City in March 2020, reports of sexually transmitted infections declined. Prediction models developed to estimate the incidence of early syphilis and gonorrhea during the COVID-19 pandemic were used to study impact on STI diagnoses/reporting and inform sexual health program planning.
