Cochranholme1814
Keeping informed given rapid trend in data and resources about covid-19 is a new challenge. Different user groups (researchers/doctors, practitioners, public) vary in linguistic expression and vocabulary so a new retrieval framework might likewise vary to improve retrieval, expose unanticipated concepts, and establish a sustainable research stream. In this project a document collection about covid-19 was created, parsed according to ISO12620's definition of linguistic register, and retrieval sets compared. Results suggest trends from other fields parallel register-oriented criteria; project exposes unexpected concepts across groups, uses of visualization, and warrants ling-register as a sustainable IR research stream.COVID-19 has become a global pandemic affecting billions of people. #link# Its impact on societies worldwide will be felt for years to come. The purpose of this research is to examine information flows about COVID-19 to understand the information-specific underpinnings that are shaping understandings of this crisis. link2 As a starting point, this research analyzes information about COVID-19 from a selection of information sources, including the World Health Organization (WHO), the National Health Commission of the People's Republic of China (NHCPRC), and three news outlets with vast global coverage. The analysis reveals some distinctive information underpinnings about COVID-19, including (a) flows of information becoming regular and larger around certain dates, (b) preponderance of information imperfections such as incomplete information, misinformation, and disinformation, and (c) absence of information about some key turning points. The implications of these information imperfections in that they create information failures and, hence, ineffective approaches to dealing with this crisis warrant further investigation.In the fight against the COVID-19 pandemic, understanding how the public responds to various initiatives is an important step in assessing current and future policy implementations. In this paper, we analyzed Twitter tweets using topic modeling to uncover the issues surrounding people's discussion of the disease. Our focus was on temporal differences in topics, prior and after the declaration of COVID-19 as a pandemic. Nine topics were identified in our analysis, each of which showed distinct levels of discussion over time. Our results suggest that as the pandemic progresses, the concerns of the public vary as new developments come to light.Systemic delivery of therapeutics for treatment of lung diseases has several limitations including poor organ distribution of delivered payload with relatively low accumulation of active substances in the lungs and severe adverse side effects. In contrast, nanocarrier based therapeutics provide a broad range of opportunities due to their ability to encapsulate substances with different aqueous solubility, transport distinct types of cargo, target therapeutics specifically to the deceased organ, cell, or cellular organelle limiting adverse side effects and increasing the efficacy of therapy. Moreover, many nanotherapeutics can be delivered by inhalation locally to the lungs avoiding systemic circulation. In addition, nanoscale based delivery systems can be multifunctional, simultaneously carrying out several tasks including diagnostics, treatment and suppression of cellular resistance to the treatment. Nanoscale delivery systems improve the clinical efficacy of conventional therapeutics allowing new approaches for the treatment of respiratory diseases which are difficult to treat or possess intrinsic or acquired resistance to treatment. The present review summarizes recent advances in the development of nanocarrier based therapeutics for local and targeted delivery of drugs, nucleic acids and imaging agents for diagnostics and treatment of various diseases such as cancer, cystic fibrosis, and coronavirus.The deadly pandemic, coronavirus disease 2019 (COVID-19), caused due to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has paralyzed the world. Although significant methodological advances have been made in the field of viral detection/diagnosis with 251 in vitro diagnostic tests receiving emergency use approval by the US-FDA, little progress has been made in identifying curative or preventive therapies. This review discusses the current trends and potential future approaches for developing COVID-19 therapeutics, including repurposed drugs, vaccine candidates, immune-modulators, convalescent plasma therapy, and antiviral nanoparticles/nanovaccines/combinatorial nanotherapeutics to surmount the pandemic viral strain. Many potent therapeutic candidates emerging via drug-repurposing could significantly reduce the cost and duration of anti-COVID-19 drug development. Gene/protein-based vaccine candidates that could elicit both humoral and cell-based immunity would be on the frontlines to prevent the disease. Many emerging nanotechnology-based interventions will be critical in the fight against the deadly virus by facilitating early detection and enabling target oriented multidrug therapeutics. The therapeutic candidates discussed in this article include remdesivir, dexamethasone, hydroxychloroquine, favilavir, lopinavir/ritonavir, antibody therapeutics like gimsilumab and TJM2, anti-viral nanoparticles, and nanoparticle-based DNA and mRNA vaccines.
During the COVID-19 outbreak, healthcare Authorities of Lombardy modified the regional network concerning time-dependent emergencies. Specifically, 13 Macro-Hubs were identified to deliver timely optimal care to patients with acute coronary syndromes (ACS). Aim of this paper is to present the results of this experience.
This is a multicenter, observational study. A total of 953 patients were included, presenting with STEMI in 57.7% of the cases. About 98% of patients received coronary angiography with a median since first medical contact to angiography of 79 (IQR 45-124) minutes for STEMI and 1262 (IQR 643-2481) minutes for NSTEMI.A total of 107 patients (11.2%) had SARS-CoV2 infection, mostly with STEMI (74.8%). The time interval from first medical contact to cath-lab was significant shorter in patients with COVID-19, both in the overall population and in STEMI patients (87 (IQR 41-310) versus 160 (IQR 67-1220) minutes, P=0.001, and 61 (IQR 23-98) versus 80 (IQR 47-126) minutes, P=0.01, respectively). In-hospital mortality and cardiogenic shock rates were higher among patients with COVID-19 compared to patients without (32% vs 6%, P<0.0001, and 16.8% vs 6.7%, P<0.0003, respectively).
During the COVID-19 outbreak in Lombardy, the redefinition of ACS network according to enlarged Macro-Hubs allowed to continue with timely ACS management, while reserving a high number of intensive care beds for the pandemic. Patients with ACS and COVID-19 presented a worst outcome, particularly in case of STEMI.
During the COVID-19 outbreak in Lombardy, the redefinition of ACS network according to enlarged Macro-Hubs allowed to continue with timely ACS management, while reserving a high number of intensive care beds for the pandemic. Patients with ACS and COVID-19 presented a worst outcome, particularly in case of STEMI.
Falls are the leading cause of fatal injury, and most common cause of non-fatal trauma, among older adults. see more sought to elicit older patient's perspectives on fall risks for the general population as well as contributions to any personal falls to identify opportunities to improve fall education.
Ten patients with a history of falls from inpatient trauma and outpatient geriatric services were interviewed. Transcripts were analyzed independently by five individuals using triangulation and constant comparison (NVivo11, QSR International) to compare fall risks to fall causes.
All patients reported that either they (9/10 participants) or someone they knew (8/10) had fallen. Despite this, only two personally worried about falling. Patient perceptions of fall risks fell into seven major themes physiologic decline (8/10); underestimating limitations (7/10); environmental hazards (7/10), lack of awareness/rushing (4/10), misuse/lack of walking aids (3/10); positional transitions (2/10), and improper footwear (1were more likely to blame environmental hazards or rushing, and minimized the role of physiologic decline and personal limitations.In Ontario, Canada, there is a need for an easily accessible training for forensic nurse examiners on the provision of care for abused older adults. In this study, our objective was to develop and evaluate a novel elder abuse nurse examiner e-learning curriculum focused on improving the care provided to older adults. The curriculum was launched on an online learning management system to forensic nurses working across Ontario's hospital-based violence treatment centers in June 2019 and evaluated using pre- and post-training questionnaires that measured self-assessed changes in knowledge and skills-based competence related to providing elder abuse care. There were significant improvements pre- to post-training in self-reported knowledge and competence across all core content domains Older Adults and Abuse; Documentation, Legal, and Legislative Issues; Interview with Older Adult, Caregiver, and Other Relevant Contacts; Initial Assessment; Medical and Forensic Examination; and Case Summary, Discharge Plan, and Follow-Up Care. As the curriculum enhanced the knowledge and skills associated with caring for abused older adults, it may have implications for training forensic nurse examiners and associated staff working in more than 25 countries internationally.The Coronavirus disease outbreak of 2019 has been causing significant loss of life and unprecedented economical loss throughout the world. Social distancing and face masks are widely recommended around the globe in order to protect others and prevent the spread of the virus through breathing, coughing, and sneezing. To expand the scientific underpinnings of such recommendations, we carry out high-fidelity computational fluid dynamics simulations of unprecedented resolution and realism to elucidate the underlying physics of saliva particulate transport during human cough with and without facial masks. Our simulations (a) are carried out under both a stagnant ambient flow (indoor) and a mild unidirectional breeze (outdoor); (b) incorporate the effect of human anatomy on the flow; (c) account for both medical and non-medical grade masks; and (d) consider a wide spectrum of particulate sizes, ranging from 10 micro m to 300 micro m. We show that during indoor coughing some saliva particulates could travel up to 0.48 m, 0.73 m, and 2.62 m for the cases with medical-grade, non-medical grade, and without facial masks, respectively. link3 Thus, in indoor environments either medical or non-medical grade facial masks can successfully limit the spreading of saliva particulates to others. Under outdoor conditions with a unidirectional mild breeze, however, leakage flow through the mask can cause saliva particulates to be entrained into the energetic shear layers around the body and transported very fast at large distances by the turbulent flow, thus, limiting the effectiveness of facial masks.
