Quinlanhaagensen8601

Poly (ADP-ribose) polymerase inhibitors exhibit strong activity for treating the DNA damage repair defect in patients with prostate carcinoma (PCa). Although conventional DNA-damaging agents can theoretically lead to synthetic antitumoral effects, no report has clearly mentioned the clinical use of cisplatin for treating PCa patients with the breast cancer gene (BRCA)2 mutation. We administered 80 mg/m2 cisplatin triweekly to a patient with metastatic castration-resistant PCa (mCRPC) with the BRCA2 mutation, and after ten cycles, the prostate-specific antigen was dramatically decreased. We suggest that BRCA2 mutations may indicate the use of cisplatin for treating patients with mCRPC.The left ventricular assist device (LVAD) is an implanted mechanical pump that supports circulatory function for patients with advanced heart failure. LVAD survival has continuously improved over the last decade with an increasing number of patients requiring non-cardiac surgeries. We discuss a 77-year-old, LVAD-dependent male with an enlarging, indurated right testicular mass. Radical inguinal orchiectomy confirmed pure seminoma. The case highlights perioperative considerations in this unique cohort of patients.

Spatial behavior of patients in utilizing health care reflects their travel burden or mobility, accessibility for medical service, and subsequently outcomes from treatment. This paper derives the best-fitting distance decay function to capture the spatial behaviors of cancer patients in the Northeast region of the U.S., and examines and explains the spatial variability of such behaviors across sub-regions.

(1) 46.8%, 85.5%, and 99.6% of cancer care received was within a driving time of 30, 60 and 180 minutes, respectively. (2) The exponential distance decay function is the best in capturing the travel behavior of cancer patients in the region and across most sub-regions. (3) The friction coefficient in the distance decay function is negatively correlated with the mean travel time. (4) The best-fitting function forms are associated with network structures. (5) The variation of the friction coefficient across sub-regions is related to factors such as urbanicity, economic development level, and market competition intensity.

The distance decay function offers an analytic metric to capture a full spectrum of travel behavior, and thus a more comprehensive measure than average travel time. Examining the geographic variation of travel behavior needs a reliable analysis unit such as organically defined "cancer service areas", which capture relevant health care market structure and thus are more meaningful than commonly-used geopolitical or census area units.

The distance decay function offers an analytic metric to capture a full spectrum of travel behavior, and thus a more comprehensive measure than average travel time. Examining the geographic variation of travel behavior needs a reliable analysis unit such as organically defined "cancer service areas", which capture relevant health care market structure and thus are more meaningful than commonly-used geopolitical or census area units.The use of Industrial Internet-of-Things (IIoT) and related technology is propelling manufacturing into a new era in the fourth industry revolution characterized by ubiquitous connectivity. IIoT allows new and unprecedented interactions amongst hardware, software, and humans. Adopting the capability of IIoT with artificial intelligence tools, manufacturing systems become smart - with unprecedented gains in production agility, quality, and efficiency. One of the key enablers of the IIoT empowered smart manufacturing is connectivity and integration standards. In this paper we review the current IIoT standards used in manufacturing, present a new IIoT standards landscape for the smart manufacturing paradigm, and describe some of IIoT standards gaps.All-optical ultrasound detection bears a number of unique advantages for photoacoustic tomography, including the ability for high resolution sampling of the acoustic field and its compatibility with a wide variety of other optical modalities. However, optical schemes based on miniaturized cavities are sensitive to optical aberrations as well as manufacturing-induced cavity imperfections which degrade sensor sensitivity and deteriorate photoacoustic image quality. Here we present an experimental method based on adaptive optics that is capable of enhancing the overall sensitivity of Fabry-Pérot based photoacoustic sensors. We experimentally observe clear improvements in photoacoustic signal detection as well as overall image quality after photoacoustic tomography reconstructions when applied to mammalian tissues in vivo.

MR and CT are excellent complimentary diagnostic modalities for evaluation of hip pain which are often used together along with radiographs. read more However, CT involves radiation, which is a concern particularly in younger patients. T1VIBE is a 3D gradient echo MR sequence with high intrinsic contrast between the bone and soft tissues with multiplanar capabilities.

We performed a study to assess if TIVIBE can be used to complement MR for evaluation of hip pain in young adults and to see if measurements and angles can be calculated using T1VIBE inversion images with similar accuracy to CT scan.

A retrospective review of 50 patients aged less than 40 years, who had MR (including TIVIBE) and CT of pelvis was performed. Post surgical patients were excluded. Some important measurements such as Centre edge angle, Tonnis' angle, anterior acetabular sector angle, posterior acetabular sector angle and acetabular version were independently measured by two readers on T1 VIBE inversion and CT images separately and measurements were compared. One reader performed the measurements again to assess for intra-observer error.

There was a female predominance (37F, 13M) with an average age of 27.6 years (range of 17-39). There was no significant difference in the measurements between CT and TI VIBE inversion and there was good intra and interobservor reliability.

TI VIBE inversion sequence can be used as an alternative to CT with added advantage of alleviating the radiation exposure.

TI VIBE inversion sequence can be used as an alternative to CT with added advantage of alleviating the radiation exposure.