Bestclarke2615
The three groups had significantly different vertical U, H, and E. There were positive correlations between age and NP, PS, UP, and TS; however, no significant correlation was observed between age and EP. Age significantly correlated with the vertical U, E, and H. SHP099 cell line Correlations between age and the horizontal U, E, and H were nonsignificant.
Among primary-school children from various grades, age significantly correlated with all pharyngeal airway variables, except with EP.
Among primary-school children from various grades, age significantly correlated with all pharyngeal airway variables, except with EP.
Effective regulation of the inflammatory process is essential for pulp repair and regeneration. Meloxicam has anti-inflammatory activity in systemic administration. The purpose of this study is to observe effects of topically applied meloxicam on inflamed pulp and to explore its potential value in the treatment of pulpitis.
The coronal pulp tissues of rat molars were stimulated with 10 mg/mL lipopolysaccharide (LPS group) and then treated with 500 μmol/L meloxicam (meloxicam group). link2 The untreated pulp tissues were used as the control group. After 3 h of incubation
, the gene expression of interleukin-6 (
) and tumour necrosis factor-α (
) in each group was detected by real-time RT-PCR. The pulp tissues of each group were randomly subcutaneously implanted into nude mice, and 500 μmol/L meloxicam was injected into the subcutaneous pocket of the meloxicam group. Haematoxylin eosin staining, Masson staining and immunohistochemical staining were performed on samples after 3 days and 4 weeks retrieval, respectively.
Compared with the LPS group, the mRNA expression levels of
and
of the meloxicam group were significantly reduced
. The inflammatory response and cyclooxygenase-2 expression of the meloxicam group were decreased, and osteodentin-like tissue was generated in the pulp cross section of the meloxicam group
.
The topical application of meloxicam inhibits the inflammatory response of inflamed pulp and further promotes the formation of osteodentin-like tissues but fails to induce the formation of the pulp-dentin complex. Topically applied meloxicam has the potential to regulate pulp inflammation.
The topical application of meloxicam inhibits the inflammatory response of inflamed pulp and further promotes the formation of osteodentin-like tissues but fails to induce the formation of the pulp-dentin complex. Topically applied meloxicam has the potential to regulate pulp inflammation.
Curcumin has anti-inflammatory impacts and was suggested as an inflammatory disease therapy. This study aimed to investigate the implications of curcumin gel on experimental periodontitis (EPD) and alveolar bone loss in rats.
In this study, twenty-four male Wistar rats were divided equally into four groups negative control (with no EPD); positive control (EPD induced around lower centrals without treatment); control-treated group EPD treated with chlorhexidine; and test EPD group treated with curcumin. After 30 days, the serum concentrations of RANKL and IL-1β were measured via ELISA. All animals were sacrificed, and mandibular central incisors with the periodontium were removed. The lingual probing depth and radiographical alveolar bone loss were measured, then samples processed for routine preparation of H&E stained sections and histologically assessed for counting inflammatory cells, osteoclasts, and PDL width.
A significant decrease in the inflammatory cells infiltration, probing depth, and osteoclast numbers with the improvement of PDL associated with a reduction in RANKL and IL-1β serum concentration were seen in both EPD treated groups.
Curcumin is as effective as chlorhexidine in treating experimental periodontitis in rats. It was demonstrated to stop bone destruction related to periodontitis by regulating the RANKL and IL-1β markers level in the blood.
Curcumin is as effective as chlorhexidine in treating experimental periodontitis in rats. It was demonstrated to stop bone destruction related to periodontitis by regulating the RANKL and IL-1β markers level in the blood.
Past caries experience remains the most powerful predictor of future caries. This study was aimed at exploring the possible relationship between the caries statuses at 3-5 and 8-10 years of age and examining the predictive power of caries experience at 3-5 years of age for the caries pattern at 8-10 years of age.
A total of 76 children (43 boys and 33 girls) were included in this study from 2012 to 2018. The first caries examination, performed in 2012, was completed when participants underwent dental rehabilitation under general anesthesia at 3-5 years of age. Tooth decay was recorded based on the International Caries Detection and Assessment System criteria. The caries examination was repeated in the clinic in 2018 when the participants were 8-10 years old. Associations between the permanent and primary teeth were analyzed using the Mann-Whitney
test. The receiver operating characteristic curve analysis was performed to determine the predictive accuracy of the primary dentition.
A significant dmfs score of the primary second molar was found between groups of free dentin caries and dentin caries of the permanent first molars (p = 0.002). The calculated areas under the receiver operating characteristic curve for the dmfs score of the primary second molar was 0.74.
Caries in the primary second molars is a clinically useful predictor at 3-5 years of age for future dentin caries development on surfaces of the first permanent molars in the following 5 years.
Caries in the primary second molars is a clinically useful predictor at 3-5 years of age for future dentin caries development on surfaces of the first permanent molars in the following 5 years.
Because the anatomy and the nature of the bone tissue between the mandible and maxilla are largely different, more site-specific studies are required to improve the healing rate on medication-related osteonecrosis of the jaw (MRONJ). The present study assessed maxillary MRONJ that was treated by surgery to understand its clinical characteristics, and to identify critical factors that influenced outcomes.
The medical records of 54 patients with maxillary MRONJ who underwent surgery were retrospectively reviewed. Variables related to the prognosis of MRONJ were extracted from the medical records and imaging, and were statistically analyzed. We also evaluated the concomitant maxillary sinusitis (MS) after the surgical treatment of MRONJ, based on CT evaluation and change of symptoms.
The healing rate of surgery for maxillary MRONJ was 85.2%, which suggested that surgical treatment is an effective strategy for treating maxillary MRONJ. Multivariate analysis revealed that postoperative residual necrotic bone was a poor prognosticator for maxillary MRONJ. Among 10 patients who did not obtain healing of MS postoperatively, 8 patients showed an improvement.
Our results indicate that surgical treatment is an appropriate strategy for maxillary MRONJ and complete resection of necrotic bone (i.e., extensive surgery) is needed to obtain complete healing of maxillary MRONJ. Concomitant MS tends to be healed or improved clinically in combination with the healing of maxillary MRONJ.
Our results indicate that surgical treatment is an appropriate strategy for maxillary MRONJ and complete resection of necrotic bone (i.e., extensive surgery) is needed to obtain complete healing of maxillary MRONJ. Concomitant MS tends to be healed or improved clinically in combination with the healing of maxillary MRONJ.
It is not clear whether the ground surface of resin-based composite (RBC) polymerized requires the application of an adhesive with/without a silane to improve bond strength. This study investigated the bond strength of RBC repaired within 24 h via the application of adhesive with/without a silane.
Seventy RBC blocks were prepared and assigned to either 0 or 24 h repair stage. Each stage was divided into seven groups a control group with no surface roughening or applied adhesive, a surface-roughened group with no applied adhesive, two surface-roughened groups treated with a G-aenial Bond adhesive and a BeautiBond Multi adhesive, two surface-roughened groups treated with the previously-mentioned adhesives as well as silane coupling agents, and one group treated with a Single Bond Universal silane-containing adhesive. Microtensile bond strength (μTBS) measurements were performed after the repaired RBC blocks of each group (n = 5) had been immersed in a 37 °C water bath for 24 h. The failure mode of each sample was determined, and the data were analyzed via one-way analysis of variance and Dunnett's test (
= 0.05).
Regardless of the repair stage, the μTBS values of the adhesive-only and silane-adhesive groups did not differ significantly from those of the control group (
> 0.05). Only the no-adhesive groups exhibited a significantly time-dependent increase in adhesive failure rate.
Our results suggest that the application of adhesives either with or without silane can significantly increase the bond strength of repairs to RBCs polymerized within 24 h.
Our results suggest that the application of adhesives either with or without silane can significantly increase the bond strength of repairs to RBCs polymerized within 24 h.
There is a paucity of comprehensive information about posterior open bite (POB) in patients with temporomandibular disorders (TMD) because of its rare prevalence. The purpose of this study was to investigate the etiologies, clinical characteristics, and treatment outcomes of patients with TMD presenting POB.
This study includes a careful review of medical records and imaging findings of 12 patients with TMD (seven men and five women, 50.9 ± 19.2 years, 15-72 years) complaining of POB.
In total, 11 had unilateral POB, whereas 1 had bilateral POB. In 11 patients, POB was caused by inflammatory disorders of temporomandibular joint (TMJ). In the remaining one patient, TMJ medial disc displacement (MDD) was responsible for POB. Of 11 patients with inflammatory conditions of TMJ, four patients had unilateral TMJ internal derangement (ID), two had bilateral TMJ ID, and one had rheumatism. POB was resolved in 10 of 11 patients with TMJ inflammation following the administration of non-steroidal anti-inflammatory drugs and self-management instructions. Prosthodontic treatment was needed in one patient to resolve POB. POB was resolved in the patient with TMJ MDD after stabilization splint therapy.
POB in patients with TMD was mostly caused by inflammatory disorders of TMJ. TMJ MDD could also be a reason. link3 Although almost all POB was resolved by conservative treatments including medications, the possibility of prosthodontic, orthodontic, or surgical treatments also must be considered.
POB in patients with TMD was mostly caused by inflammatory disorders of TMJ. TMJ MDD could also be a reason. Although almost all POB was resolved by conservative treatments including medications, the possibility of prosthodontic, orthodontic, or surgical treatments also must be considered.
