Shahflindt9653

Corticosteroid injections are an effective treatment for many medical conditions. However, clinicians must be aware of potential side effects of this treatment modality so that proper patient counseling can take place. Patients with pigmentary alteration after intra-articular or intralesional corticosteroid injections have rarely been reported in literature. We present an adult male patient with linear depigmentation after an intralesional corticosteroid injection for a Morton's neuroma.BACKGROUND Photodynamic therapy (PDT) is a well-known treatment modality for actinic keratosis (AK). The largest surface area approved by the FDA is 20cm2 with 10% 5-aminolevulinic acid hydrochloride gel (10% ALA gel). OBJECTIVE This retrospective study assessed the tolerability of PDT with 10% ALA gel in areas ranging from 75cm2 to 300cm2. METHODS The medical records of 203 patients with AKs treated with 376 PDT sessions using 10% ALA gel were reviewed. Face and ears were incubated with 10% ALA gel for 60 minutes without occlusion while all other areas were incubated for 90 minutes with plastic wrap occlusion followed by 10J/cm2 blue light. Patients were given specific post-PDT care directions. Patient outcomes data was collected. RESULTS Skin irritation was reported in 27 (7%) PDT sessions in 25 patients (12%). These occurred primarily on the face (n=17), hands (n=4,) and scalp (n=3). Of the 349 PDT treatments (93%) without irritation, these subjects reported adherence to a specific post-PDT regimen using zinc oxide and healing creams for 48 hours. LIMITATIONS This was a retrospective study observing safety and tolerability. Clearance data was not collected. CONCLUSION Based on this retrospective observational case series, PDT with ALA gel appears to be safe for treating patients with AKs covering surface areas 75 to 300cm2. Irritation might be mitigated by post-PDT care regimens.BACKGROUND The management of melasma remains a challenge in dermatology, despite the availability of a variety of therapies, such as sunscreens, hypopigmented topical treatments, and chemical peels. The ideal treatment for melasma should be efficient, conclusive, and free from side effects. OBJECTIVE The aim of this study is to assess the efficacy and tolerability of a depigmenting agent complex, based on the synergy of oligopeptide-68, phytic acid, glycolic acid, lactic acid, and octinoxate measured by clinical and reflectance confocal microscopy outcomes in melasma patients. METHODS Twenty female patients exhibiting clinical evidence of melasma, aged between 29 and 61 years, were randomly enrolled in the study. Reflectance confocal microscopy was performed at baseline and after three months of treatment. RESULTS Clinically, all patients showed significant improvement in melasma after treatment without adverse reactions. A relevant improvement in the treated skin areas was also assessed using reflectance confocal microscopy analysis. CONCLUSION This study suggests that a combination of topical agents containing oligopeptide-68, phytic acid, glycolic acid, lactic acid, and octinoxate produces significant rapid improvement in melasma at clinical and cellular levels.OBJECTIVE The Vycross™ range of hyaluronic acid (HA) fillers supports a full-face approach to facial rejuvenation. It is important to understand how much filler can be safely injected and which products to use where, particularly for injectors who are new to this range. This study assessed whether Vycross fillers can be effectively and safely used in larger quantities and tracked real-world usage across facial zones. METHODS This was a single-center, retrospective analysis set in normal clinical practice. The study included 66 consecutive adult female patients undergoing full-face rejuvenation with Vycross fillers within a single treatment plan guided by MD Codes. Filler usage and location were noted, and any adverse events were recorded. Olaparib in vitro RESULTS The mean age was 48.0 years, and median time from consultation to first filler usage was 18 days. Most patients (n=40; 60.6%) had only one filler session. Forty-seven patients (71.2%) also received botulinum toxin type A. In total, 309 filler syringes were used (mean 4.7 per patient). Sixteen (5.2%), 181 (58.6%), and 112 (36.2%) syringes were used in the upper, mid and lower face, respectively. In the upper and midface, the majority was Voluma (15/16 and 120/181 syringes, respectively). In the lower face, filler use was split across Voluma, Volift and Volbella (41, 44 and 27 syringes, respectively). Five adverse events were reported at three weeks (swelling, n=2; asymmetry, n=2; lumps, n=1). All were easily resolved. No delayed events were reported. CONCLUSION Substantial volumes of Vycross fillers can be effectively and safely used as part of a full-face approach to facial rejuvenation.Acne vulgaris is the most common dermatological disease in the United States, affecting up to 85 percent of teenagers. While the American Academy of Dermatology has established guidelines regarding acne treatment in general, the variability among acne treatments, even within a given class, prevents establishment of a straightforward regimen. For example, moderate to severe acne is generally treated with an oral antibiotic, although several options are available-both across and within antibiotic classes. The aim of this review is to report the efficacy and safety data available for commonly prescribed oral antibiotics. While there are currently no data to support superiority of one drug over another, there are substantial differences in safety profiles and brand-specific features that may make one antibiotic preferable over another.BACKGROUND Despite the many theories that have been published over the years, the exact pathology of chronic urticaria (CU) is still largely unknown. Eosinophils have been implicated in many cutaneous disorders-serving as major effector cells, inducing tissue damage and dysfunction by releasing granule proteins, including eosinophil cationic protein (ECP), inflammatory lipid mediators, mitochondrial DNA, and eosinophil-derived neurotoxin (EDN), which is relatively neutral with some cytotoxic properties. OBJECTIVE We sought to evaluate serum levels of EDN in patients with CU and to correlate their levels with the severity of their disease. PARTICIPANTS Fifty patients with CU and 30 matching healthy individuals, serving as controls, were recruited from the outpatient clinic of the Dermatology, Venereology, and Andrology Department of Benha University Hospitals. METHODS 5ml of venous blood were drawn from all participants in a fasted state, stored in sterile tubes, and used to measure the serum level of EDN following the manufacturer's instructions.