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The objective of this review is, therefore, to highlight the new elements showing the preventive and beneficial effects of n-3 LC-PUFAs against the development and progression of breast cancer.Unlocking the relationship between regional integration and urban green development efficiency (UGDE) is of great importance for boosting regional high-quality development and promoting sustainable urban development patterns. Although studies have analyzed the spatio-temporal evolution and influencing factors of regional integration and UGDE, the impact of regional integration on UGDE remains untested. In this paper, we construct a conceptual framework to analyze how regional integration can influence UGDE through promoting the factors mobility and optimizing the industrial layout. In addition, we further choose the urban agglomeration in the middle reaches of the Yangtze River (UAMRYR), a rapidly growing urban agglomeration in central China, as a case to investigate the spatial spillover effect of regional integration on UGDE from 2003 to 2017. We quantify the UGDE with a random forest model, then estimate the underlying determinants of the UGDE with a spatial Durbin model. Results indicated that (1) the regional integration level and the UGDE index of the UAMRYR and its three sub-urban agglomerations show an increasing trend; (2) for every 1% increase in the level of regional integration, the level of UGDE will increase by 0.8307%; (3) the impact of regional integration on UGDE has obvious regional heterogeneity; while playing a promoting effect in the Wuhan urban agglomeration and the Changsha-Zhuzhou-Xiangtan urban agglomeration, it shows an inhibitory effect in the Poyang Lake urban agglomeration. We conclude that regional integration in agglomeration areas can accelerate the factors flow and optimize the industrial layout for improving UGDE.

This study aimed to (1) evaluate the psychometric properties of a Comprehensive Short-Form Geriatric Depression Scale (GDS-SF) and (2) examine the associated factors of GDS-SF among the elderly.

A cross-sectional study was conducted from November 2019 to April 2020 in Dhaka City Corporation, Bangladesh. Data of 377 elderly were collected, including socio-demographic characteristics, social supports, comorbidities, sleep behaviours, and depression (as measured by the GDS-SF). We used the principal component analysis, correlation analysis, and logistic regression analysis to validate GDS-SF, and explore its associations.

The GDS-SF was reliable and homogeneous with Cronbach's alpha = 0.836, and McDonald's Omega = 0.841, with no floor/ceiling effects. The questionnaire demonstrated a good construct validity with item-scale convergent validity and KMO measure of sampling adequacy (0.869 for the total sample, 0.838 for the community subsample, and 0.851 for the slum subsample). In the multivariate model, older people had a higher likelihood of moderate and severe depression (OR, 1.06; 95% CI, 1.00, 1.12;

= 0.048). The likelihood of having moderate and severe depression was lower in men (OR, 0.48; 95% CI, 0.28, 0.85;

= 0.011) and those satisfied with their children's support (OR, 0.17; 95% CI, 0.08, 0.35;

< 0.001), compared with their counterparts, respectively.

The GDS-SF is a reliable and valid survey tool for evaluating depression in Bangladeshi older adults. Age, gender, and satisfaction with children's support were predictors of depression.

The GDS-SF is a reliable and valid survey tool for evaluating depression in Bangladeshi older adults. Age, gender, and satisfaction with children's support were predictors of depression.Beach sand may act as a reservoir for numerous microorganisms, including enteric pathogens. Several of these pathogens originate in human or animal feces, which may pose a public health risk. In August 2019, high levels of fecal indicator bacteria (FIB) were detected in the sand of the Azorean beach Prainha, Terceira Island, Portugal. Remediation measures were promptly implemented, including sand removal and the spraying of chlorine to restore the sand quality. To determine the source of the fecal contamination, during the first campaign, supratidal sand samples were collected from several sites along the beach, followed by microbial source tracking (MST) analyses of Bacteroides marker genes for five animal species, including humans. Some of the sampling sites revealed the presence of marker genes from dogs, seagulls, and ruminants. Making use of the information on biological sources originating partially from dogs, the municipality enforced restrictive measures for dog-walking at the beach. Subsequent sampling campaigns detected low FIB contamination due to the mitigation and remediation measures that were undertaken. This is the first case study where the MST approach was used to determine the contamination sources in the supratidal sand of a coastal beach. Our results show that MST can be an essential tool to determine sources of fecal contamination in the sand. This study shows the importance of holistic management of beaches that should go beyond water quality monitoring for FIB, putting forth evidence for beach sand monitoring.Inflammatory bowel disease (IBD) diagnoses are increasing in Japan. Some patients have symptoms that are difficult to control, and further research on IBD is needed. Claims databases, which have a large sample size, can be useful for IBD research. However, it is unclear whether the International Classification of Diseases, Tenth Revision (ICD-10) codes alone can correctly identify IBD. We aimed to develop algorithms to identify IBD in claims databases. We used claims data from the Department of Gastroenterology, Tohoku University Hospital from 1 January 2016 to 31 December 2020. We developed 11 algorithms by combining the ICD-10 code, prescription drug, and workup information. We had access to the database which contains all the information for Crohn's disease and ulcerative colitis patients who visited our department, and we used it as the gold standard. We calculated sensitivity, specificity, positive predictive value (PPV), and negative predictive value for each algorithm. We enrolled 19,384 patients, and among them, 1012 IBD patients were identified in the gold standard database. Among 11 algorithms, Algorithm 4 (ICD-10 code and ≥1 prescription drugs) showed a strong performance (PPV, 94.8%; sensitivity, 75.6%). The combination of an ICD-10 code and prescription drugs may be useful for identifying IBD among claims data.

The globally increasing healthcare expenditures related to the need to treat the consequences of adverse events, as well as the number of claims filed by patients (or their families) and remuneration paid as their result mean that the interest in the subject of adverse event cost management is increasing. An increase in the number of cases concerning medical errors has also occurred in Poland in recent years. The newest statistics from the Ministry of Justice demonstrate that the courts are awarding increasingly higher amounts. selleck The goal of this work was an attempt to approximate, based on our own experiences, the impact of adverse events on the expenditures of the healthcare system in Poland, including the costs of treatment of the consequences of such events, described by the authors as "secondary harm".

Based on the analysis of 100 cases for compensation for the occurrence of a medical event, an initial estimate of the costs of primary (initial) treatment, which resulted in the occurrence of the adversehors of the article are of an opinion that all the conducted analyses and conclusions drawn from them should serve the improvement of patient safety. They also form an initial point for establishing recommendations and advice for the improvement of safety and quality of medical services and the reduction of healthcare-related costs. The authors propose covering the parties injured by an adverse event (subjected to "secondary harm") with a unique, innovative programme of post-accident health care, "Health Reconstruction".International students in China were among the first group of individuals to be affected by the COVID-19 pandemic. However, the pandemic's impact on their mental health is underexplored. This study-utilizing web-based survey data (N = 381), presents preliminary reports using ANOVA and MIMIC analytic approaches. Following the clinical demarcation of the 21-item version of the Depression Anxiety Stress Scales (DASS-21), we found 24.6%, 38.3%, and 43.6% of the students to suffer mild to extreme stress, anxiety, and depression, respectively. Female students reported significantly higher levels of stress and depression than males. Older students' reports of stress were more substantial than younger students. Students who reported having a relative infected with the virus (vs. those without) experienced significantly higher anxiety and stress. Those who reported having pre-existing chronic health condition(s) (vs. those without) also reported significantly higher stress, anxiety, and depression levels. Moreover, students with an exercise routine (vs. those without) experienced significantly lower levels of stress, anxiety, and depression. Last, our MIMIC model results indicate that foreign students' age, gender, chronic health status, and having a relative infected with the virus constitute significant risk factors explaining variations in foreign students' experience of psychological distress. Implications for international students' management have been thoroughly discussed.Purpose of this study is to analyze factors affecting the healthy aging of the elderly with chronic diseases living in the community according to the worldwide aging phenomenon in line with the WHO's healthy aging strategy. The subjects were 116 elderly aged 65 years or up with one or more chronic diseases and residing in four cities. The collected data were analyzed by using the descriptive statistics, t-test, ANOVA, Pearson's correlational coefficients, and stepwise multiple regression. The healthy aging of subjects showed positive correlations with the health status (r = 0.68, p < 0.001), gerotranscendence (r = 0.64, p < 0.001), self-efficacy (r = 0.65, p < 0.001), and social support (r = 0.47, p < 0.001), while the healthy aging and depression (r = -0.58, p < 0.001) showed a negative correlation. The factors affecting the healthy aging were health status (β = 0.24, p = 0.004), self-efficacy (β = 0.28, p < 0.001), education (β = -0.11, p = 0.057), exercise (β = 0.17, p = 0.003), gerotranscendence (β = 0.22, p = 0.004), and depression (β = -0.19, p = 0.009), and the explanatory power of those variables was 68.2%. Thus, it would be necessary to provide an intervention for the elderly that could habituate health-related education and exercise, maintain good health status, lower depression, aid control of themselves through the gerotranscendence, and increase self-efficacy.Under current conditions, the green economy concept has received a comprehensive response in achieving the sustainable development of regions. However, measuring green economic development progress is dynamic, quantitatively characterized by indicators reflecting various aspects. The difficulty lies in a comprehensive environmental sustainability assessment in a context that includes the territory's environmental, social, and economic factors. The study aimed to assess the progress of the Republic of Buryatia's (Russia) "green" economic development. The proposed methodology for constructing a composite index is based on five dimensions' aggregation-resource efficiency, environmental efficiency, environmental quality of life, natural assets, and institutional factors. The composite index helped generalize the complex processes of the region's environmental-socio-economic development. Its main feature is the reflection of the environmental specificity of the territory. We built a mid-term forecast of the composite and sub-indices, determined their future trend, and assessed the opportunities and conditions for the fastest transition of the Republic of Buryatia to a green economy.