Kristensenbolton8118

ObjectiveTo explore end-of-life care in the ward and intensive care unit (ICU) environment in nine Australian hospitals in a retrospective observational study.MethodsIn total, 1693 in-hospital deaths, 356 in ICU, were reviewed, including patient demographics, advance care plans, life-sustaining treatments, recognition of dying by clinicians and evidence of the palliative approach to patient care.ResultsMost patients (n=1430, 84%) were aged ≥60 years, with a low percentage (n=208, 12%) having an end-of-life care plan on admission. Following admission, 82% (n=1391) of patients were recognised as dying, but the time between recognition of dying to death was short (ICU (staying 4-48h) median 0.34 days (first quartile (Q1), third quartile (Q3) 0.16, 0.72); Ward (staying more than 48h) median 2.1 days (Q1, Q3 0.96, 4.3)). Although 41% (n=621) patients were referred for specialist palliative care, most referrals were within the last few days of life (2.3 days (0.88, 5.9)) and 62% of patients (n=1047) experienced actove the patient experience of end-of-life care.

To analyze the trend of food intake from Chinese 15 provinces(autonomous regions, municipalities) adult aged 18 to 35.

Based on the data from 10 rounds follow-up survey conducted by China Health and Nutrition Survey between 1989 and 2015, adults aged 18 to 35 were selected according to the multi-stage stratified random cluster sampling method. Dietary surveys were conducted using 24-hour dietary recall in three consecutive days, and weighing accounting method was used to investigate the consumption of condiments. Wilcoxon rank sum trend was used to test the variation trend of food intake, Cochran-Armitage trend test and Spearman rank test were used to analyze the trend of different type of food intake and the recommended intakes of dietary pagoda for Chinese residents(2016).

The intake of fruits, livestock and poultry meat, aquatic products, eggs, milk and dairy products, soybeans and nuts and sugar for adults aged 18-35 in China has been increasing. Cereals and potatoes, vegetables, edible oil, cookingry fiber. The proportion of whose consumed cereals, potatoes, vegetables and dairy products lower than EAR and exceed EAR of meat and cooking salt shows an increasing trend. The problem of unreasonable dietary structure is still serious.

To study the eating out behavior and its impact on obesity among Chinese residents aged 18-59.

Multistage stratified random sampling method was used to collect data in 302 monitoring sites of the China National Chronic Non-communicable Disease and Nutrition Surveillance of adults in 31 provinces of China from 2015. A total of 53 887 subjects were included in this study by data cleaning. The population data published by the National Bureau of Statistics in 2010 were used as a standard population of the data result for 2015. Complex sampling weighting method was adopted in data analyses. The number and percentage of cases were used to describe the eating behaviors of different characteristics of the population, Statistical analysis was conducted by using SURVEYFREQ process, and Chi-square test was used to comparative analysis. Multi-factor analysis was conducted to the relationship between eating out frequency and different characteristics and obesity by using SURVEYLOGISTIC model regression.

In 2015, pro9, men who ate out 14-21 times a week showed higher risk of obesity.

To analyze the levels of serum ferritin(SF), transferrin receptor(sTfR), vitamin D(VD), folate(FOL), vitamin B_(12)(VB_(12)) and homocysteine(Hcy) of pregnant women and lactating mothers in rural areas, aiming to evaluate the nutritional status of pregnant women and lactating mothers.

By using a cluster sampling method, the subjects were the pregnant women at 10-20 weeks& apos; gestation and lactating mothers at 42±7 days& apos; postpartum who have been to the maternal and children health hospital in the county for examination from August 2019 to March 2020. SF, VD, VB_(12) and FOL concentrations were determined using the chemiluminescence assay. Hypersensitive C-reactive protein(hsCRP) and sTfR levels were determined using the immunoturbidimetry assay. Hcy levels were determined using the enzymatic assay. The rates of iron, vitamin D, folic acid, VB_(12) deficiency and hyperhomocysteinemia(HHcy) were calculated.

There were 1050 pregnant women and 309 lactating mothers involved. The levels of fet women and 29. 8%, 2. 3% and 27. 8% for lactating mothers, which were significant different between pregnant women and lactating mothers(P& lt; 0. 05). AS-703026 mouse Among the four nutrients including iron, VD, folate and VB_(12), 75. 8% of pregnant women were deficient in at least one nutrient and 28. 1% were deficient in at least two nutrients. 81. 9% of lactating mothers were deficient in at least one nutrient and 41. 4% were deficient in at least two nutrients.

There were various degrees of nutrient deficiency. Iron deficiency rates were high and VD deficiency were severe in both pregnant women and lactating mothers. In addition, the rates of folate deficiency and HHcy were high in lactating mothers in rural areas.

There were various degrees of nutrient deficiency. Iron deficiency rates were high and VD deficiency were severe in both pregnant women and lactating mothers. In addition, the rates of folate deficiency and HHcy were high in lactating mothers in rural areas.

Near-infrared(NIR) spectroscopy combined with partial least squares(PLS) were applied to establish a rapid method for green direct determination of mineral elements(calcium, phosphorus and potassium) in wheat flour samples.

NIR spectra and analytical measurements of calcium, phosphorus and potassium were collected from 117 wheat flour samples with different processing levels(whole grain wheat, special grade No. 1 wheat and wheat core flour). Principal components analysis(PCA) was developed to assign 81 wheat flour samples to build models and 36 samples as the validation set to evaluate the performance of the developed models. The influence of wavelength range and spectral preprocessing method on the predictive ability of the model were discussed, and the best models were selected.

For calcium, the best NIR model showed a good prediction performance(r~2=0. 7907, RMSEP=5. 35, RPD=2. 19); the best NIR model for phosphorus gave an excellent prediction performance(r~2=0. 9777, RMSEP=15. 3, RPD=6. 71); the best model for potassium also gave an excellent prediction performance(r~2=0. 9777, RMSEP=18. 9, RPD=6. 84).

NIR spectroscopy can realize the rapid prediction of mineral elements(calcium, phosphorus and potassium) in wheat flour. By selecting the wavelength range and spectral preprocessing method, the prediction ability of the NIR model can be significantly improved.

NIR spectroscopy can realize the rapid prediction of mineral elements(calcium, phosphorus and potassium) in wheat flour. By selecting the wavelength range and spectral preprocessing method, the prediction ability of the NIR model can be significantly improved.

To establish a rapid and accurate method for the determination of trace acetaldehyde, acrolein, methacrylaldehyde, crotonaldehyde in the air by ultra-fast liquid chromatography-tandem mass spectrometry(UFLC-MS/MS).

The air sample was concentrated and derivatived by 3-methyl-2(3 H)-benzothiazolonhydrazone(MBTH), and the effect of derivative conditions including the concentration of MBTH, the pH, the derivative time and temperature was investigated. The stability of derivatives, the cracking mechanism of mass spectrometry, the matrix effect of the method and air sampling efficiency were studied. The chromatographic separation was carried out on a Shim-pack XR-ODS II column(100 mm×2. 0 mm, 2. 2 μm) by using water/methanol solution as the mobile phase with the gradient elution. Detection was performed in positive multi-reaction monitoring(MRM) mode for quantification by using external standard method.

The four analytes showed good linear relationship within the range of 1. 00-100 μg/L(calculated by aldehyde) with a correlation coefficient r≥0. 9990. The limits of quantitation(LOQs) of the method(concentrated with 10 L air) were 0. 5 μg/m~3 in air, for acetaldehyde, acrolein, methacrylaldehyde, crotonaldehyde. The recoveries of the method were 90. 6%-97. 8% at the three spiked levels, and the relative standard deviations(RSDs) were between 1. 9%-6. 4%(n=6), the average sampling efficiency was between 91. 0%-97. 1%.

The developed method is simple, less interference and specificity, and is suitable for the simultaneous rapid determination of trace acetaldehyde, acrolein, methacrylaldehyde, crotonaldehyde in air of work place.

The developed method is simple, less interference and specificity, and is suitable for the simultaneous rapid determination of trace acetaldehyde, acrolein, methacrylaldehyde, crotonaldehyde in air of work place.

To investigate the protective effect of 1, 25(OH)_2D_3 on Aβ_(1-42)-induced pyrolysis in PC12 cells.

The Alzheimer& apos; s disease model in PC12 cells was established with 20 μmol/L Aβ_(1-42). The experiment was divided into control group, model group(20 μmol/L Aβ_(1-42)) and 1, 25(OH)_2D_3 groups(1, 10, 100 nmol/L 1, 25(OH)_2D_3+20 μmol/L Aβ_(1-42)). Cell activity was detected by CCK-8, cell membrane permeability was detected by AO/EB staining, lactic dehydrogenase(LDH)and interleukin-1β(IL-1β)were detected by colorimetry and ELISA, NOD-like receptor family protein 1(NLRP1), cysteinyl aspartate specific proteinase-1(caspase-1)and gasdermin D(GSDMD)protein expression were detected by Western Blot.

Compared with the control group, the cell activitywas significantly decreased(P& lt; 0. 01), cell membrane permeability, the level of LDH and IL-1β, and the expression of NLRP1, caspase-1 and GSDMD were significantly increased(P& lt; 0. 01). Compared with the model group, the cell activity was significantly increased(P& lt; 0. 01), cell membrane damage was decreased in PC12 cells exposed to 1, 25(OH)_2D_3. The level of LDH and IL-1β were significantly decreased(P& lt; 0. 01) in PC12 cells exposed to 10 and 100 nmol/L 1, 25(OH)_2D_3. The expression of NLRP1 and GSDMD in 1 nmol/L 1, 25(OH)_2D_3 group was decreased(P& lt; 0. 05), and the decrease was more significant in 10 and 100 nmol/L 1, 25(OH)_2D_3 groups(P& lt; 0. 01). The expression of caspase-1 was significantly decreased in 10 and 100 nmol/L 1, 25(OH)_2D_3 groups(P& lt; 0. 05, P& lt; 0. 01).

1, 25(OH)_2D_3 exerts a significant protective effect against Aβ_(1-42)-induced PC12 cells injury through inhibition of neuronal pyrolysis.

1, 25(OH)_2D_3 exerts a significant protective effect against Aβ_(1-42)-induced PC12 cells injury through inhibition of neuronal pyrolysis.

To investigate the effect of decabromodiphenyl ether(BDE-209) on glucose and lipid metabolism and adipocytokines in mice.

A total of 36 adult male C57 BL/6 mice were randomly divided into 6 groups, 1000, 800, 600, 450 and 300 mg/kg groups and the control group, with 6 in each group. 60 days after gavage, fasting overnight, the mice were killed and the corresponding test materials were taken. Using an automatic biochemical analyzer to detect triglycerides(TG), total cholesterol(cholesterol, TC), low-density lipoprotein(LDL-C), and high-density lipoprotein(HDL-C). Detected rat fasting blood glucose(FBG) with Roche blood glucose meter. Observed the morphological changes of mouse liver tissue using HE staining. Determined leptin(LEP), the mRNA and protein expression levels of adiponectin(ADP) and peroxisome proliferators-activated receptors(PPAR)-γ with Real-time fluorescent quantitative PCR and Western blotting.

The levels of fasting serum lisulin(FINS), insulin sensitivity index(ISI), ADP and HDL-C in the serum of the BDE-209 exposure group decreased(P& lt; 0.