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Sagittal alignment improved in both groups. Statistically significant PDFA changes were observed in the tension-band plate group (P = 0.0095); a trend was noted toward improvement in ACL angle (P = 0.08). PPTA did not change. No changes reached significance in the transphyseal screw group (PDFA P = 0.181, ACL P = 0.64). Tension-band plate migration was noted in one (7.7%) of 13 knees, and transphyseal screw migration in nine (56.3%) of 16 knees (P less then 0.01). Anterior distal femoral growth modulation improves sagittal alignment without significant remodeling at the proximal tibia. Hardware migration occurred more often with transphyseal screws (P less then 0.01). We recommend dual anterior tension-band plating over placement of paired screws for sagittal growth modulation to treat knee flexion contracture.Objective Late presentation of developmental dysplasia of the hip (DDH) remains a major orthopedic problem. However, existing management is not standardized and is highly surgeon dependent.The theory behind femoro-acetabular zones (FAZ) system is to find a relationship between acetabular maturity and severity of dislocation in one hand, and the outcome of closed reduction, on the other hand in late presenting cases. Patients and methods A retrospective study was performed on children with untreated DDH that underwent closed treatment. Our series consisted of 65 hips; mean patient age was 24 months (range 9-30 months) with a minimum follow-up of 3 years. FAZ classification was applied to the pre-reduction pelvic radiograph, while the results were evaluated according to Severin's scoring system. Results Overall, 37 of 65 hips (57%) achieved a satisfactory outcome (Severin I and II), while 22 hips (33%) were found to be unsatisfactory (Severin III). Six hips (10%) needed an open reduction. FAZ expressed a simple and reliable classification in predicting the success of closed reduction. Conclusion This novel X-ray-based classification system can easily predict patients with DDH in whom a closed reduction is likely to succeed and defer patients with higher grades to surgical intervention. Yet, its validity has to be verified in larger cohort studies and directly compared to the established International Hip Dysplasia Institute classification.Background Legg-Calvé-Perthes disease (LCPD) often produces a residual deformity, typically consistent with coxa magna, coxa plana, and ellipsoidal shape. Depending on the degree of asphericity and flatness, this morphology was classified by Stulberg in stages III and IV. Thus far, few studies have investigated physeal injury as an etiological cause or evaluated its progressive profile throughout Waldenström's reossification stage and the remodelling stage. In this study, we analysed the ellipsoidal process of the femoral head. Methods This was a retrospective control case study involving 83 unoperated hips with LCPD and Stulberg stages III and IV outcome. The data were compared with those obtained for 49 healthy contralateral hips (control). The Ellipsoidal Index, the presence of a double epiphyseal reossification nucleus, physeal narrowing, intraphyseal angle, epiphyseal height, diameter of the head, and Reimer's Index were determined. Measurements were performed at four-time points the year the reossificatmetrical narrowing of the physis and a high Ellipsoidal Index, which may be indicative of poor prognosis.Levels of Evidence for Primary Research Question Level III, case-control study.There has been an upsurge in the number of practices owned by non-physicians. Phorbol myristate acetate With orthopaedic surgery as the next frontier in this market, orthopaedists need to consider the ethical consequences of such acquisitions. The history and trends of practice ownership are reviewed alongside how laws shifted to reflect a changing health-care climate. The 4 tenets of bioethics (beneficence, nonmaleficence, autonomy, and justice) are explored with regard to practice acquisition by non-physician entities. Although non-physician-owned corporations and private equity firms provide liquidity to the health-care sector, there are ethical concerns that may ultimately impact patient care. Orthopaedic surgeons must be cautious when engaging in acquisitions with non-physician-owned entities, as the goals of each party may not align. This may yield situations that infringe on the basic principles of bioethics for both physician and patient.Background The spine-pelvis-hip interaction during postural change should be considered in the functional anatomy of the hip. The component parts of this anatomy and how they influence hip function are important to know. Pelvic incidence (PI) is one of these components. We studied if PI was preoperatively predictive of impingement risk and if it postoperatively influences hip position, which could cause outliers from the functional safe zone of hip replacement. Methods This was a prospective radiographic study of 187 consecutive patients (200 hips) who had lateral spinopelvis-hip radiographs before and after primary total hip arthroplasty with measurements of the component factors that influence mobility and position of the functional anatomy. The predictive value of PI for risk of impingement of the hip and its postoperative relationship to functional safe-zone outliers were assessed. Forty-one dislocations from our clinical practice were also reviewed. Results Of 200 hips, the PI was normal in 145 hips (73%), low in 18 hips (9%), and high in 37 hips (19%). Eighty-two hips had spinopelvic imbalance 12 (67%) of the 18 hips with low PI, 56 (39%) of the 145 hips with normal PI, and 14 (38%) of the 37 hips with high PI. Low-PI hips was the most predictive of the risk of impingement and postoperatively these hips had the most outliers from the functional safe zone. Conclusions PI is an anatomical component that is predictive of both impingement risk and functional safe-zone outliers. Preoperative risk, based on factors such as the Lewinnek zones and combined anteversion, is an established guide in determining cup position in hip replacement. Low-PI hips that have the "terrible triad" of a posteriorly tilted pelvis, stiff pelvic mobility, and increased femoral flexion therefore have no functional safe zone. Level of evidence Prognostic Level IV. See Instructions for Authors for a complete description of levels of evidence.Introduction Understanding and meeting the patients' preoperative expectations for anterior cruciate ligament (ACL) reconstruction (ACLR) is critical for achieving successful patient-centered outcomes. There is currently no standardized method to assess preoperative expectations of ACLR based on the patient-derived methods. The purpose of this study was to develop and test a patient-derived patient expectations survey specific to primary ACLR. link2 We hypothesized that a valid and reliable patient-derived survey could be developed to measure these expectations and that patients would have diverse expectations before surgery. Methods The Hospital for Special Surgery ACL-expectation score was developed through a four-phase iterative process that included item generation and pilot survey development, item reduction, survey readability, and survey validation. Seventy-two patients were involved in the development phase, and 80 patients were included in the validation phase. Discriminant validity testing was performed ra preoperative measure of patient expectations.Introduction The benefit of indomethacin suppositories for prophylaxis against post-ERCP pancreatitis (PEP) in high-risk patients was established in a landmark trial published in 2012. The aims of this study were to measure the adoption of indomethacin prophylaxis in widespread clinical practice, evaluate concurrent trends in pancreatic duct (PD) stent utilization, and estimate the impact of these changes on PEP in a high-risk population. Methods Data were extracted from a commercial database (Explorys, IBM Watson Health, Somers, NY) that aggregates electronic health records from 26 US healthcare systems from 2009 to 2018. Using Systematized Nomenclature of Medicine Clinical Terms, we identified a cohort of patients who underwent endoscopic retrograde cholangiopancreatography (ERCP) and were at high risk for PEP based on narrow criteria. PEP was defined as an emergency department or hospital admission 1-5 days after ERCP with an associated diagnosis of pancreatitis. Results Twenty six thousand eight hundred tement are more appropriately used in clinical practice.Purpose The present study investigated muscle metabolism and fatigue during simulated elite male ice hockey match-play. Methods Thirty U20 male national team players completed an experimental game comprising three periods of 8x1-min shifts separated by 2-min recovery intervals. Two vastus lateralis biopsies were obtained either during the game (n=7) or pre- and post-game (n=6). Venous blood samples were drawn pre-game and at the end of the first and last period (n=14). link3 Activity pattern and physiological responses were continuously monitored using local positioning system and heart rate recordings. Further, repeated-sprint ability was tested pre-game and after each period. Results Total distance covered was 5980±199 m with almost half the distance covered at high skating speeds (>17 km·h). Average and peak on-ice heart rate was 84±2 and 97±2% of maximum heart rate, respectively. Muscle lactate increased (P≤0.05) more than 5- and 3-fold, while muscle pH decreased (P≤0.05) from 7.31±0.04 pre-game to 6.99±0.07 and 7.13±0.11 during the first and last period, respectively. Muscle glycogen decreased by 53% post-game (P≤0.05) with ~65% of fast- and slow-twitch fibers depleted of glycogen. Blood lactate increased 6-fold (P≤0.05), while plasma free fatty acid levels increased 1.5- and 3-fold (P≤0.05) after the first and last period. Repeated-sprint ability was impaired (~3%; P≤0.05) post-game concomitant with a ~10% decrease in the number of accelerations and decelerations during the second and last period (P≤0.05). Conclusion Our findings demonstrate that a simulated ice hockey match-play scenario encompasses a high on-ice heart rate response and glycolytic loading resulting in a marked degradation of muscle glycogen, particularly in specific sub-groups of fibers. This may be of importance both for fatigue in the final stages of a game and for subsequent recovery.Purpose We examined whether two weeks of one-leg immobilization would impair leg microvascular function and to what extent a subsequent period of intense aerobic cycle training could restore function. Methods Study participants were healthy young males (n=12; 20-24 years of age). Leg microvascular function was determined before the intervention, after the immobilization period and after a four-week exercise training period. Microvascular function was assessed as the vasodilator response to intra-arterial infusion of acetylcholine, sodium nitroprusside and as the vasoconstrictor response to endogenous noradrenaline release induced by tyramine infusion. Vasodilator enzymes as well as pro- and antioxidant enzymes were assessed by protein analysis in skeletal muscle samples; endothelial nitric oxide synthase (eNOS), NADPH oxidase (NOXp67 and NOXgp91) and superoxide dismutase 2 (SOD2). Results The acetylcholine induced change in vascular conductance was reduced after the two weeks of immobilization (P=0.003), tended to increase after the subsequent four weeks of exercise training (P=0.

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