Mccrackenspencer1206

aureus-infected wounds healing, as well as no damage to normal tissues. Besides, the antibacterial dressing was prepared to a band aid with excellent water swelling and antibacterial properties, which was further fixed in a medical tape to construct a portable antibacterial product that can be applied to the surface of human skin and showed excellent waterproof performance, providing a new insight for the construction of clinical antibacterial wound healing products.A novel seedbed-like scaffold was firstly fabricated by the "frozen sectioning" processing method using Flammulina velutipes as a raw material. read more The Flammulina velutipes polysaccharides scaffold is composed of a natural structure imitating the "ground" (connected and aligned hollow tubes with porous walls). Meanwhile, its biologically active components include polysaccharides and proteins, mimicking the "plant nutrition" in the seedbed. To further optimize the ground and nutrition components, Flammulina velutipes polysaccharides-derived scaffolds (FPDSs) were fabricated via the treatment of original Flammulina velutipes polysaccharides scaffold (labeled FPS) by NaOH, cysteine (labeled as FPS/NaOH, FPS/Cys, respectively). FPDSs were characterized by SEM, FTIR, XRD, water absorption and retention, and mechanical evaluations. From the results, FPS/NaOH and FPS/Cys lost the characteristic big tubes of original strips and had higher water absorption capacities comparing to FPS. Simultaneously, FPS/NaOH had better dling.A novel grafting polymer was synthesized via grafting of diphenylamine (DPA) onto sodium alginate (NaAlg) as a new adsorbent for Cobalt (Co2+) from aqueous solutions. Optimization of sodium alginate grafted by diphenylamine (NaAlg-g-DPA) was addressed in the current study by several parameters including; initiator and monomer concentrations, contact time of polymerization, as well as polymerization temperature. In addition, the structural and chemical characteristics of NaAlg-g-DPA were explored using different modalities later. The results showed that sodium alginate grafted by diphenylamine (NaAlg-g-DPA) is suitable for adsorbent to removal Co2+ ion. The parameters for the adsorption of Co(II) ions by NaAlg-g-DPA were also determined. It was shown that the samples of NaAlg-g-DPA had given good correlation with Temkins isotherm model and their kinetics followed pseudo-second-order model. It was also observed that the adsorption capacity seemed to be dependent on pH value in solution which showed better results at basic pH. The findings from this research show that NaAlg-g-DPA has capability to remove Co (II) from aqueous solutions.Juvenile hormone diol kinase (JHDK) is an important enzyme involved in the juvenile hormone metabolism pathway, which catalyzes the phosphorylation of juvenile hormone diol to form the polar metabolite JH diol phosphate. Here, we reported the first crystal structure of insect JHDK from Bombyx mori, BmJHDK-L2, determined at a resolution of 1.22 Å. The structure of BmJHDK-L2 mainly comprises of eight α-helical segments linked with loops, forming four helix-loop-helix motifs. In these four helix-loop-helix motifs with only one calcium ion bound in the first motif. Circular dichroism spectra indicated that BmJHDK-L2 has strong thermal stability, which is independent of the divalent cation. The structure of BmJHDK-L2 further allowed us to define an ATP-binding site using computational simulation and binding assays, providing a structural basis for development of inhibitor of JHDK. Moreover, the expression profile of BmJHDK-L2 indicated a predominant role in juvenile hormone metabolism in the Malpighian tubules of silkworm. Collectively, these findings expand our knowledge regarding the structural and biochemical features of insect JHDK proteins.Solubilization studies of tadalafil (TDF) have recently improved the dissolution (%) using weak acids and bases in our group. However, the weak acid formulations have a low dissolution (%) of TDF as limitation. Thus, the purpose of this study was to improve the dissolution (%) of TDF over 90% in distilled water (DW) by weak acid-chitosan based multi-system. The SD formulation (SD11 TDF, tartaric acid, chitosan, Aerosil®200, and PVP/VA S-630 in a 12112 weight ratio) showed higher dissolution (%) of TDF by 5.0-, 6.0-, and 5.8-fold at 60 min than that of Cialis® in DW and pH 1.2 and pH 6.8 buffers, respectively. The physical properties of the SD11 formulation were changed. Moreover, the SD11 formulation maintained stability for 3 months. In conclusion, the solubilization of TDF using chitosan was successfully performed for the first time.Superdisintegrants have an important function in Fast dissolving tablets (FDT). It's believed that an increase in surface to the mass (size reduction) can enhance their performance. Due to the obligation of pharmaceutical excipients being in GRAS (generally recognized as safe) list, we've devoted our research to modify one of the routinely used and important natural polymer, cellulose, as superdisintegrant. Nanocrystalline cellulose (NCC) was extracted from microcrystalline cellulose (MCC) via the sulfuric acid hydrolysis process. NCC derivatives have been synthesized by Itaconic acid/Hydroxyethyl methacrylate (IA/HEMA) via maleic anhydride (MA) to acquire unique swellability properties in to achieve superabsorbent cellulose-based nano hydrogel with the cross-linking system. The disintegration performance of prepared tablets was compared with tablets composed of sodium starch glycolate (SSG) and MCC as positive and negative controls. The results show that the disintegration time of tablets formulated with synthesized modified NCC (m-NCC) decreased dramatically compared to other disintegrants. The dissolution analysis showed suitable condition for complete drug release in a shorter time. The in vitro cytotoxic experiments proved the biocompatibility of newly synthesized superdisintegrant. The dissolution Analysis findings suggest that our developed novel superdisintegrant paves the way for the formulation of fast dissolving tablets containing rapidly acting medicines such as zolpidem.