Steffensenappel2096

Six cases of pneumonitis (9%; all grade 1 or 2), an adverse event of special interest, were observed. The confirmed objective response rate (ORR) was 39%, including 5 complete responses and 21 partial responses, and the median PFS was 6.9 months. The combination was particularly active in the subset of patients (n = 16) who were bevacizumab-naïve, less heavily pretreated (1-2 prior lines), and whose tumors exhibited medium/high FRα expression (ORR, 56% with a median duration of response of 12 months; PFS, 9.9 months). CONCLUSION The combination of mirvetuximab soravtansine with bevacizumab is well tolerated in patients with platinum-resistant, recurrent ovarian cancer. The encouraging efficacy measures compare favorably to reported outcomes for bevacizumab combined with standard chemotherapy in similar patient populations. OBJECTIVE Characterize change in rates of minimally invasive (MIS) radical hysterectomy after presentation of the LACC trial. METHODS Longitudinal analysis of data from Vizient® database for surgically treated patients with invasive cervical cancer from April 2017-March 2019. Covariates studied included patient demographic and obesity categories, dates of LACC trial presentation and publication, and hospital characteristics. RESULTS 2102 cervical cancer patients had surgery at 201 hospitals. Most were age 31-50 (51.2%), White (64.8%), and had public (49.2%) health insurance. Annual rates of MIS fell from 51.9% to 27.1% after the LACC trial presentation (RR 0.52, 95% CI 0.47, 0.58; p  less then  0.0001). Adjusting for within hospital correlation, the odds of MIS dropped by 13% per month (OR = 0.872 per month, 95% CI 0.852, 0.891; p  less then  0.001), without further change in rates of MIS after the peer-review publication (OR = 1.033 per month, 95% CI 0.897, 1.189; p = 0.65). Rates of MIS declined across all demographics (RR = 0.32-0.65; p  less then  0.01), except in morbidly obese women (RR = 0.90; p = 0.60). Applying mixed effects model, rates of MIS fell by 3% per month in morbidly obese women versus 18% per month if body mass index less then 40 kg/m2. NCCN member hospitals and hospitals with gynecologic oncology fellowship training programs significantly reduced rates of MIS radical hysterectomy faster, but not earlier, than other hospitals. CONCLUSIONS Rates of MIS radical hysterectomy fell dramatically and pervasively after the LACC trial presentation, despite ongoing substantive controversy. Practice pattern changes were not significant in morbidly obese women. Studies of endodontic outcomes suggest that fracture of the tooth after endodontic therapy may be a greater problem than endodontic reinfection. Immediate full coverage with or without a post and core is the best way to prevent fracture. Unfortunately, in many population areas, due predominantly to cost, this restoration is often delayed, leading to fracture of the tooth. Reviews of several in vitro studies suggest that a composite restoration reinforced with glass fibers, particularly with fiberglass posts laid horizontally in a buccolingual direction, significantly increased the resistance to fracture. This case report describes in detail the placement of horizontal posts in an endodontically treated molar to reinforce the coronal structure. In the discussion, we outlined the agreement of most of the authors on the increase in fracture resistance and the lack of consensus on what constitutes a catastrophic fracture. INTRODUCTION An accurate diagnosis is required for the appropriate management of endodontic conditions. It is unknown whether the specific descriptive terminology used in diagnosis influences treatment decision making. The aim of this study was to determine whether treatment choices made by dentists are influenced by the diagnostic terminology used. METHODS One hundred ninety-four dentists in Australia were recruited through the Australian Dental Association to complete an online survey regarding 14 endodontic cases. Respondents selected treatment options based on a given diagnosis and radiograph. Gefitinib Data were analyzed using SPSS software (Version 26; IBM Corp, Armonk, NY) and the exact McNemar test to determine if there was a difference between treatment choices for matched diagnoses with different terminology. RESULTS More dentists chose to manage irreversible pulpitis operatively when the descriptive term chronic was used compared with asymptomatic (93.3% vs 59.8%, χ12 = 57.69, P less then .005). This trend was repeated when using chronic or asymptomatic to describe apical periodontitis (96.9% vs 89.7%, exact P = .004) and apical abscesses (99.0% vs 83.5%, χ12 = 104.125, P less then .005). The differences between acute and symptomatic were less dramatic but still presented significant differences in treatment choices for an apical abscess described as "primary acute" or "secondary acute" compared with "symptomatic" (82.0% and 96.4% vs 93.3%, P less then .05). CONCLUSIONS Descriptive terminology, specifically the terms acute and chronic as opposed to symptomatic and asymptomatic, used in the diagnosis of endodontic conditions did influence whether clinicians chose operative management or nonoperative management. Further research is warranted to determine the extent of this influence among dentists. INTRODUCTION The suitability of EndoSequence BC Sealer (BC Sealer; Brasseler USA, Savannah, GA) for warm vertical compaction has been questioned. The aim was to evaluate the cytotoxicity and the effect of heating on the physicochemical properties of a new calcium-based root canal sealer (EndoSequence BC Sealer HiFlow [HiFlow]) in comparison with EndoSequence BC Sealer. METHODS Human periodontal ligament fibroblasts were incubated for 1, 2, or 3 days with material extracts of different concentrations, and cell viability was evaluated by Cell Counting Kit-8 (Enzo Life Sciences Inc, Burlington, Ontario, Canada). The setting time, flow, film thickness, microhardness, radiopacity, and radiopacity of the 2 sealers were measured according to ISO 6786/2012. The continuous changes in viscosity were tested by a stress-controlled rheometer at shear rates ranging from 0.01-10 s-1 and different temperatures, and chemical composition was assessed by Fourier-transform infrared spectroscopy. RESULTS Cell viability was significantly decreased on day 3 for the 14 diluted extract from both materials.