Jonssonwood1164

Besides, the hippocampi of CdCl2-treated rats had higher levels of TNF-α (197%), and IL-6 (190%) with a concomitant increase in nuclear activity and levels of NF-κB p65 (721% & 554%). Besides, they showed reduced nuclear activity (53%) and levels (74%) of SIRT1, higher nuclear activity and levels of PARP1 (292% & 138%), increased nuclear levels of p53 (870%), and higher acetylated levels of NF-κB p65 (513%), p53 (644%), PARP1 (696%), and FOXO-2 (149%). All these events were significantly reversed in the CdCl2 + Kaempferol-treated rats. Of note, Kaempferol also increased levels of MnSOD (73.5%), and GSH (40%), protein levels of Bcl-2 (350%), and nuclear activity (67%) and levels (46%) of SIRT1 in the hippocampi of the control rats. In conclusion, Kaempferol ameliorates CdCl2-induced memory deficits and hippocampal oxidative stress, inflammation, and apoptosis by increasing SIRT1 activity and inhibiting PARP1 activity. Due to the increasing concerns on environmental pollution, fossil energy shortage, and sustainable development, the recycling of industrial by-products had become a popular practice worldwide. Chemical stabilization of problematic soils with biomass by-product lignin was being considered as one of the viable answers to the consumption of such lignin stockpiles and the reduction of environmental loading. This paper summarized the production and physicochemical properties of by-product lignin collected from paper mills and reviewed the state of the art of this lignin stabilized soils as engineering materials. In addition, the potential focuses requiring further study to promote lignin stabilization technology were expected. The results showed that physicochemical properties of by-product lignin were mainly controlled by plant biomass and production technology, which should be clearly examined before field application. By-product lignin exhibited a satisfactory performance of improving engineering properties of both cohesive soils and noncohesive soils with respect to strength, erosion resistance, and durability. The precipitated cementing materials bonded particles and filled pores in the soil matrix, while their formation mechanism had not clearly explored yet. By-product lignin stabilized soils suffered from performance deterioration as exposed to moisture intrusion and wetting-drying cycle. The formed bonding among soil particles was essential in affecting the mechanical responses and durability of stabilized soils. Cu-CPT22 molecular weight The desirable construction procedure and protective measure were encouraged to be established for safety applications of the stabilized soils. Additional researches were recommended to by-product lignin optimization/modification, dynamic behaviors of stabilized soils, and application in some special soils. The outcomes of this review are invaluable in facilitating application of biomass by-product lignin for stabilizing problematic soils in engineering constructions. V.Information on soil loss and sediment export is essential to identify hotspots of soil erosion to inform conservation interventions in a given watershed. This study investigates the dynamics of soil loss and sediment export associated with land-use/land cover changes and identifying soil loss hotspot areas in the Winike watershed of the Omo-Gibe Basin of Ethiopia. Spatial data collected from satellite images, topographic maps, meteorological and soil data were analyzed. The land-use types in the study area were categorized into six cultivated land, woodland, forest, grazing, shrubland, and bare land. The Integrated Valuation of Ecosystem Services and Tradeoffs (InVEST) of the sediment delivery ratio (SDR) model was used based on the analysis of land use/land cover and RUSLE factors. The results show that total soil loss increased from 774.86 thousand tons in 1988 to 951.21 thousand tons in 2018 while the corresponding sediment export increased by 3.85 thousand tons for the same period. These were subsequently investigated in each land-use type. Cultivated fields generated the highest soil erosion rate, increasing from 10.02 t/ha/year in 1988 to 43.48 t/ha/year in 2018 when compared with the grazing, shrub, forest, wood land and bare land-use types. This corresponds with the expansion of the cultivated area. This is logical as the correlation between soil loss and sediment delivery and expansion of cultivated area is highly significant (p  less then  0.001). Sub-watershed six (SW-6) showed the highest soil loss (23.17 t/ha/year) while sub-watershed two (SW- 2) has the lowest soil loss (5.54 t/ha/year). This is because SW-2 is situated in the lower reaches of the watershed under dense vegetation cover experiencing less erosion. The findings on the erosion hotspots presented in this study allow prioritizing the segments of the watershed that need immediate application of improved management interventions and informed decision-making processes. The secondary aerosol formation mechanism in the presence of ammonia (NH3), is poorly understood, especially under high relative humidity (RH) conditions. In this study, a total of seven experiments were conducted from toluene/NOx photo-oxidation in the presence/absence of NH3 under dry (~7% RH) and wet (>60% RH) conditions in a ~3 m3 smog chamber. A series of instruments including gas analysers, scanning mobility particle sizer (SMPS), aerosol mass spectrometry (HR-ToF-AMS) etc. were applied to measure the NOx and O3 concentrations, the mass concentration and chemical composition of secondary aerosol. It was found that NH3 could enhance the mass loading of secondary aerosol, especially under wet condition. However, the presence of NH3 or increasing RH did not have a significant influence on SOA yield. The organic aerosol mass spectrum from AMS showed that the most abundant fragment was at m/z = 44, which was mainly from the fragmentation of carboxylic acids. Compared to the absence of NH3, the fraction of fragment at m/z = 44 and OC was higher in the presence of NH3, regardless of dry or wet conditions. The highest OC value of 0.71-0.75 was observed in the presence of NH3 under wet condition, suggesting there could be a synergetic effect between the high RH and the presence of NH3, which jointly contributed to the photochemical aging process of SOA. The NC increased in the presence of NH3 under both dry and wet conditions, which might be attributed to the carboxylates and organic nitrates formed from the reaction between NH3 and carboxylic acids. The results implied that SOA modelling should consider the role of NH3 and water vapour, which might fill the gap of OC between laboratory studies and field measurements. Agricultural water resource, mainly consumed through evapotranspiration, plays a critical role in agricultural production of arid and semiarid regions. Quantifying the changes of evapotranspiration in cropland (ETc), and its driving factors, may provide rich information for improving human land-use and water resource management. Here we first investigated the multi-year (2000-2015) changes in the ETc (mm yr-1) and associated driving factors of the Loess Plateau (LP), using a combination of the Vegetation Interfaces Processes model and a factorial analysis of variance. We found that the ETc of the LP showed a significant upward trend of 0.31 km3 yr-2 (3.33 mm yr-2) (p  less then  .05) over the last 16 years, mainly driven by cropland changes (3.77% per year), which combined the contribution of cropland area changes and cropland leaf area index (LAIc) changes. We then examined the changes of the dominant driving factor cropland, and results indicated that the cropland changes consisted of the decrease in cropland area (net decrease of 10.50 × 103 km2) and the increase in LAIc (increased by 10.72%), which suggest the actual contribution of the ETc uptrend was the increasing LAIc. Our further analysis on the causes of the increasing LAIc by correlating the LAIc with land-use management factors revealed that the cropland greening on the LP showed high positive correlations with the increasing inputs of total power of agriculture machinery and farm plastic film, followed by chemical fertilizer. The increase of LAIc was also promoted by the increased ratio of the garden fruits output to total crops output (increased by 67.12%) and multiple cropping (increased by 21.66%). These results suggest that the ETc uptrend can be related to the agricultural intensification. Our study highlights the need for a realistic representation of socio-economic development and human land-use practices in the sustainable optimal allocation of agricultural water resources on the LP. The detection of microplastics and nanoplastics in the environment, especially plastic particles in aquatic environments in situ, still faces challenges due to the limitations of current methods, instruments and size of plastic particles. This paper evaluates the potential of surface-enhanced Raman spectroscopy for the analysis of microplastics and nanoplastics. The condition of different tests including the volume ratio of sample to silver colloid, the concentrations of NaCl, and the concentrations of the samples, are assessed for the study of microplastics and nanoplastics (polystyrene (PS), polyethylene (PE) and polypropylene (PP)) in pure water and seawater. A method based on SERS, that uses silver colloid as the active substrate, is developed for the qualitative analysis of microplastics and nanoplastics in aquatic environments. The particle sizes of microplastics and nanoplastics include 100 nm, 500 nm and 10 μm. The Raman signals of microplastics and nanoplastics in pure water and seawater both show good enhancement efficiency. The optimal enhancement factor is 4 × 104. The SERS-based detection method overcomes the limitations of microplastics and nanoplastics in liquids and can detect 100 nm plastics down to 40 μg/mL. It provides more possibility for the rapid detection of microplastics and nanoplastics in aquatic environments in the future. V.Elevated blood pressure (BP) is a major avoidable cause of premature morbidity and mortality in the United States (US) and worldwide, due primarily to increased risks of stroke as well as myocardial infarction. While there are therapeutic lifestyle changes and adjunctive pharmacologic medications of proven benefit, recent interest has increasingly focused on Complementary and Alternative Medicine, in particular, Mind-Body Interventions. With respect to BP, it is tempting to speculate that mindfulness with paced breathing will have beneficial effects in the short run that may translate into lowered risks of stroke in the long run. Paced breathing is deep diaphragmatic breathing with typical rates equal to or less than 5-7 breaths per minute compared with the usual rate of 12-14. One plausible mechanism of benefit is that paced breathing stimulates the parasympathetic nervous system which alters neuronal function in specific areas of the brain and reduces stress chemicals. The hypothesis that mindfulness with paced slow breathing reduces BP could be directly tested in randomized trials designed a priori to do so. Subsequently, a finding that mindfulness with paced breathing reduces BP would also lead to direct tests in randomized trials of reductions of carotid atherosclerosis and, if so, a larger scale trial to test whether there is a direct impact of mindfulness with paced breathing on reducing the risks of stroke and MI. If rigorous testing of this medical hypothesis led to positive results this would have large and important clinical and policy implications in the US and worldwide.