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The PST module selects reliable pseudo labels through a novel uncertainty guided self-training loss to obtain accurate prototypes in the target domain. The DR module reconstructs original images jointly utilizing prediction results and private prototypes to maintain semantic consistency and provide complement supervision information. We extensively evaluate the proposed model in polyp segmentation performance on three conventional colonoscopy datasets CVC-DB, Kvasir-SEG, and ETIS-Larib. The comprehensive experimental results demonstrate that the proposed model outperforms other state-of-the-art methods.Non-invasive heart rate estimation is of great importance in daily monitoring of cardiovascular diseases. In this paper, a bidirectional long short term memory (bi-LSTM) regression network is developed for non-invasive heart rate estimation from the ballistocardiograms (BCG) signals. The proposed deep regression model provides an effective solution to the existing challenges in BCG heart rate estimation, such as the mismatch between the BCG signals and ground-truth reference, multi-sensor fusion and effective time series feature learning. Allowing label uncertainty in the estimation can reduce the manual cost of data annotation while further improving the heart rate estimation performance. Compared with the state-of-the-art BCG heart rate estimation methods, the strong fitting and generalization ability of the proposed deep regression model maintains better robustness to noise (e.g., sensor noise) and perturbations (e.g., body movements) in the BCG signals and provides a more reliable solution for long term heart rate monitoring.The tracking control is investigated for a class of uncertain strict-feedback systems with robust design and learning systems. Using the switching mechanism, the states will be driven back by the robust design when they run out of the region of adaptive control. The adaptive design is working to achieve precise adaptation and higher tracking precision in the neural working domain, while the finite-time robust design is developed to make the system stable outside. To achieve good tracking performance, the novel prediction error-based adaptive law is constructed by considering the estimation performance. Furthermore, the output constraint is achieved by imbedding the barrier Lyapunov function-based design. The finite-time convergence and the uniformly ultimate boundedness of the system signal can be guaranteed. Simulation studies show that the proposed approach presents robustness and adaptation to system uncertainty.When a fingerpad presses into a hard surface, the development of the contact area depends on the pressing force and speed. Importantly, it also varies with the finger's moisture, presumably because hydration changes the tissue's material properties. Therefore, we collected data from one finger repeatedly pressing a glass plate under three moisture conditions, and we constructed a finite element model that we optimized to simulate the same three scenarios. We controlled the moisture of the subject's finger to be dry, natural, or moist and recorded 15 pressing trials in each condition. The measurements include normal force over time plus finger-contact images that are processed to yield gross contact area. We defined the axially symmetric 3D model's lumped parameters to include an SLS-Kelvin model (spring in series with parallel spring and damper) for the bulk tissue, plus an elastic epidermal layer. Particle swarm optimization was used to find the parameter values that cause the simulation to best match the trials recorded in each moisture condition. The results show that the softness of the bulk tissue reduces as the finger becomes more hydrated. The epidermis of the moist finger model is softest, while the natural finger model has the highest viscosity.The current practice of administering neurofeedback using the patients' visual and/or auditory channel(s) is known to cause fatigue, excessive boredom, and restricted mobility during prolonged therapy sessions. selleck chemicals llc This paper proposes haptics as an alternative means to provide neurofeedback and investigates its effectiveness by conducting two user studies (Study- I & II) using a novel compact wearable haptic device that provides vibrotactile feedback to the user's neck. Each user study has three neurofeedback modes visual-only, haptics-only, and visual-and-haptics combined. Study- I examines the participant's performance in a brain-training task by measuring their attention level (AL) and the task completion time (CT). Study- II, in addition to the brain-training task, investigates the participants' ability to perform a secondary task (playing a shape-sorting game) while receiving the neurofeedback. Results show that users performed similarly well in brain-training with haptics-only and visual-only feedback. However, when engaged in a secondary task, the users performed significantly better (AL and CT improved around 11% and 17%, respectively) with haptics, indicating a clear advantage of haptics over visual neurofeedback. Being able to perform routine activities during brain-training would likely increase user adherence to longer therapy sessions. In the future, we plan to verify these findings by conducting experiments on ADHD-patients.Round genomes are found in bacteria, plant chloroplasts, and mitochondria. Genetic or epigenetic marks can present biologically interesting clusters along a circular genome. The circular data clustering problem groups time. The core is a fast optimal framed clustering algorithm, which we designed by integrating two divide-and-conquer and one bracket dynamic programming strategies. The algorithm is optimal based on a property of monotonic increasing cluster borders over frames on linearized data. On clustering 50,000 circular data points, FOCC outruns brute-force or heuristic circular clustering by three orders of magnitude. We produced clusters of CpG sites and genes along three round genomes, exhibiting higher quality than heuristic clustering. More broadly, the presented subquadratic-time algorithms offer the fastest known solution to not only framed and circular clustering, but also angular, periodical, and looped clustering. We implemented these algorithms in the R package OptCirClust (https//CRAN.R-project.org/package=OptCirClust).Genome Rearrangements are events that affect large stretches of genomes during evolution. Many mathematical models have been used to estimate the evolutionary distance between two genomes based on genome rearrangements. However, most of them focused on the (order of the) genes of a genome, disregarding other important elements in it. Recently, researchers have shown that considering regions between each pair of genes, called intergenic regions, can enhance distance estimation in realistic data. Two of the most studied genome rearrangements are the reversal, which inverts a sequence of genes, and the transposition, which occurs when two adjacent gene sequences swap their positions inside the genome. In this work, we study the transposition distance between two genomes, but we also consider intergenic regions, a problem we name Sorting by Intergenic Transpositions. We show that this problem is NP-hard and propose two approximation algorithms considering two distinct definitions for the problem. We also investigate the problem called Sorting by Signed Intergenic Reversals and Intergenic Transpositions. We show that this problem is NP-hard and develop two approximation algorithms. We study how these algorithms behave when assigning weights for genome rearrangements. Finally, we implemented all these algorithms and tested them on real and simulated data.DNA sequencing techniques are critical in order to investigate genes' functions. Obtaining fast, accurate, and affordable DNA bases detection makes it possible to acquire personalized medicine. In this article, a semi-empirical technique is used to calculate the electron transport characteristics of the developed z-shaped graphene device to detect the DNA bases. The z-shaped transistor consists of a pair of zigzag graphene nanoribbon (ZGNR) connected through an armchair graphene nanoribbon (AGNR) channel with a nanopore where the DNA nucleobases are positioned. Non-equilibrium Green's function (NEGF) integrated with semi-empirical methodologies are employed to analyze the different electronic transport characteristics. The semi-empirical approach applied is an extension of the extended Hückel (EH) method integrated with self-consistent (SC) Hartree potential. By employing the NEGF+SC-EH, it is proved that each one of the four DNA nucleobases positioned within the nanopore, with the hydrogen passivated edge carbon atoms, results in a unique electrical signature. Both electrical current signal and transmission spectrum measurements of DNA nucleobases inside the device's pore are studied for the different bases with modification of their orientation and lateral translation. Moreover, the electronic noise effect of various factors is studied. link2 The sensor sensitivity is improved by using nitrogen instead of hydrogen to passivate the nanopore and by adding a dual gate to surround the central semiconducting channel of the z-shaped graphene nanoribbon.Molecular communication, as an emerging research direction, has emerged in the field of communication, which usually combined with nanotechnology and bio-related knowledge. In the direction of communication channel research, the most widespread model for a molecular communication channel is the diffusion-based channel, where the information-carrying molecules propagate randomly in the medium based on Brownian motion. Multi-input multi-output (MIMO) technology is often used to improve communication quality in the traditional communication field. Compared with the SISO model, which only has inter-symbol interference (ISI) as the interference source, the interference in MIMO communication model includes ISI as well as inter-link interference (ILI), which emerges when receiver receive other transmitters' molecules. In this paper, MIMO communication models are built, based on diffusion channel, CSK, probabilistic theory, considered with ISI and ILI, to establish the calculation formula of related bit error rate, And the influence of relevant parameters in the model on bit error rate is studied. Then, SISO and SIMO models will be built to compare with MIMO models. Last, self-adaptive dual threshold algorithm is proposed to reduce BER of the 2×2 MIMO system. Simulation results show that the proposed algorithm has better performance on reducing BER than other approaches.Autism Spectrum Disorder (ASD) affects 1 in 54 children in the United States. A core social communication skill negatively impacted by ASD is joint attention (JA), which influences the development of language, cognitive, and social skills from infancy onward. Although several technology-based JA studies have shown potential, they primarily focus on response to joint attention (RJA). link3 The other important component of JA, the initiation of joint attention (IJA), has received less attention from a technology-based intervention perspective. In this work, we present an immersive Computer-mediated Caregiver-Child Interaction (C3I) system to help children with ASD practice IJA skills. C3I is a novel computerized intervention system that integrates a caregiver in the teaching loop, thereby preserving the advantages of both human and computer-administered intervention. A feasibility study with 6 dyads (caregiver-child with ASD) was conducted. A near significant increase with medium effect size on IJA performance was observed.

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