Harboegadegaard1743

The safety and efficacy of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) in peritoneal metastasis in palliative settings remain poorly investigated and understood. Chemotherapy-refractory patients often present with symptomatic disease. This study investigated the safety and survival outcomes of optimal CRS/HIPEC performed primarily for palliation.

Palliative CRS/HIPEC was defined as asymptomatic patients who did not respond to three or more lines of chemotherapy, progression on current chemotherapy, and/or any symptomatic disease progression, including ascites, bowel obstruction, and pain. Data collected included demographics, histology, length of stay (LOS), perioperative complications, perioperative mortality, adjuvant chemotherapy use, peritoneal recurrence, overall recurrence, and overall survival.

The median number of lines of chemotherapy received prior to CRS/HIPEC was 3.2, and 81% of patients were symptomatic. There were no postoperative deaths and the major se receiving multiple lines of chemotherapy. Median survival exceeded 1 year and factors associated with longer survival were optimal CRS and adjuvant chemotherapy. Liver metastasis did not preclude survival benefit in colon cancer patients. CRS/HIPEC can be considered for palliation but should be performed at high-volume centers.

To evaluate the prognostic value of the percentage of high-grade patterns (micropapillary, solid, and complex glands) in early-stage lung adenocarcinoma (LUAD).

A total of 1049 patients undergoing radical surgery with pathological T1-2N0M0 LUAD were screened retrospectively, and 191 patients were involved in the final analysis. Disease-free survival (DFS) was evaluated using the Kaplan-Meier curve and Cox regression analysis. The optimal cut-off value was determined using maximally selected rank statistics.

The entire cohort was divided into quartile groups based on the percentage of high-grade patterns Group 1 (≤ 30%), Group 2 (31-55%), Group 3 (56-85%), and Group 4 (≥ 86%). There were significant differences in smoking history (P = 0.041), EGFR mutations (P < 0.001), and ALK rearrangement (P = 0.010) between the four groups, but no significant differences in other clinicopathological features. Kaplan-Meier analysis showed that a higher percentage of high-grade patterns predicted worse DFS (P = 0.001), and multivariate analysis indicated that the percentage of high-grade patterns was an independent predictor (Group 2 vs. Group 1, HR = 2.136, P = 0.228; Group 3 vs. Group 1, HR = 3.355, P = 0.035; Group 4 vs. Group 1, HR = 5.147, P = 0.003, respectively). A cut-off value of 20% (P = 0.048) and 50% (P <0.001) for high-grade patterns were tested, and both revealed a significant difference in distinguishing DFS between subgroups.

The percentage of high-grade patterns is associated with the prognosis of early-stage invasive LUAD. A higher percentage indicates a worse prognosis.

The percentage of high-grade patterns is associated with the prognosis of early-stage invasive LUAD. A higher percentage indicates a worse prognosis.

The purpose of this article is to summarize the opinions of the surgical oncology leaders from the Global Forum of Cancer Surgeons (GFCS) about the global impact of COVID-19 pandemic on cancer surgery.

A panel session (virtual) was held at the annual Society of Surgical Oncology 2021 International Conference on Surgical Cancer Care to address the impact of COVID-19 on cancer surgery globally. Following the virtual meeting, a questionnaire was sent to all the leaders to gather additional opinions. The input obtained from all the leaders was collated and analyzed to understand how cancer surgeons from across the world adapted in real-time to the impact of COVID-19 pandemic.

The surgical oncology leaders noted that the COVID-19 pandemic led to severe disruptions in surgical cancer care across all domains of clinical care, education, and research. Several new changes/protocols associated with increased costs were implemented to deliver safe care. Leaders also noted that preexisting disparities in care were exacerbated, and the pandemic had a detrimental effect on well-being and financial status.

The COVID-19 pandemic has led to severe disruptions in surgical cancer care globally. Leaders of the GFCS opined that new strategies need to be implemented to prepare for any future catastrophic events based on the lessons learned from the current events. The GFCS will embark on developing such a roadmap to ensure that surgical cancer care is preserved in the future regardless of any catastrophic global events.

The COVID-19 pandemic has led to severe disruptions in surgical cancer care globally. Leaders of the GFCS opined that new strategies need to be implemented to prepare for any future catastrophic events based on the lessons learned from the current events. The GFCS will embark on developing such a roadmap to ensure that surgical cancer care is preserved in the future regardless of any catastrophic global events.

The albumin-bilirubin (ALBI) grade is a useful prognostic and predictive marker for patients with liver disease. Its clinical significance has been limited to patients with colorectal cancer (CRC). Furthermore, the association between the ALBI grade and skeletal muscle-related indices is unclear.

This study enrolled 1015 patients who underwent computed tomography (CT) scans within 31days before surgery. The prognostic value of the ALBI grade in predicting overall survival (OS) was assessed using the Cox proportional hazards model. The correlation between the ALBI grade and the skeletal muscle index or radiodensity (myosteatosis) was evaluated. The predictive accuracy of ALBI alone and in combination with myosteatosis was compared using Harrell's concordance index (C-index).

The significant prognostic factors for OS identified in the multivariable analysis were the ALBI group (low vs high hazard ratio [HR], 1.566; 95 % confidence interval [CI], 1.174-2.089; p = 0.002) and myosteatosis (low vs. high HR, 0.648; 95 % CI, 0.486-0.865; p = 0.003). The rate of low-grade myosteatosis increased as the ALBI grade increased. The C-index of combined ALBI and myosteatosis (0.650; 95 % CI, 0.618-0.683) was superior to that of ALBI alone (0.603; 95 % CI, 0.575-0.631; bootstrap incremental area under the curve [iAUC] mean difference, 0.047; 95 % CI, 0.012-0.070) and myosteatosis alone (0.608; 95 % CI, 0.577-0.640; bootstrap iAUC mean difference, 0.042; 95 % CI, 0.023-0.064).

The ALBI grade is significantly associated with myosteatosis. The ALBI grade is a significant prognostic factor, and the combination of ALBI and myosteatosis show an additive value in discriminating survival of patients with CRC.

The ALBI grade is significantly associated with myosteatosis. The ALBI grade is a significant prognostic factor, and the combination of ALBI and myosteatosis show an additive value in discriminating survival of patients with CRC.Soiling has a crucial importance regarding its impact mainly for countries that have high soiling levels, dust storms, water scarcity and a great solar energy potential as the case of Morocco. Soiling mitigation is therefore mostly required during spring, due to higher pollen concentration, and summer, due to the lack of heavy precipitation. In this work, systematic measurements of soiling ratio were made in Rabat, city of north-western Morocco, during almost 1 year. Soiling has been evaluated considering the effect of dual-axis tracking that was compared to photovoltaic (PV) on fixed structure. A soiling rate of about 0.22%/day has been found for static PV while only 0.1% was found for PV on tracker. An additional approach of cleaning has been proposed in this paper which aims to use dew water. Using glass samples that were exposed to real environmental conditions, similar to the exposure conditions of PV panels, the soiling ratio was determined. At sunrise time, the subsequent change of the glass sample, from the horizontal position at night into the position of 30° tilt angle during the day, is performed to promote dew flow by the force of gravity acting on the droplets of dew. It has been found that relying only on the change of tilt angle, the average soiling losses were only 3.8% compared with 11.8% for fixed PV. This approach can reduce soiling similarly to solar trackers.Graphene photocatalysis is a new method for harmful algae and water pollution control. However, microbial communities undergoing graphene photocatalysis treatment in freshwater lakes have been poorly studied. Here, using 16S rRNA and 18S rRNA gene high-throughput sequencing, the responses of microbial communities to graphene photocatalysis were analyzed in the eutrophic lake, Lake Xinyun, southwestern China. For microeukaryotes, we found that Arthropoda was dominant in summer, while its abundant level declined in spring under natural conditions. The evident reduction of Arthropods was observed after graphene photocatalysis treatment in summer and then reached a relatively stable level. For bacteria, Cyanobacteria decreased in summer due to the graphene photocatalysis-mediated inactivation. However, Cyanobacteria was higher in the treated group in spring with a genera group-shift. Functional analysis revealed that microeukaryotes showed higher potential for fatty acid oxidation and TCA cycle in the treated group in summer, but they were more abundant in control in spring. Pathways of starch and sucrose metabolism and galactose metabolism were more abundant in control in summer, while they were enriched in the treated group in spring for bacteria. This study offers insights into the effects of graphene photocatalysis on microbial communities and their functional potential in eutrophic lake.Cotton stem is used to produce the high-efficient adsorbent (CSA) for Rhodamine B (RB) dye removal from wastewater, and hydrogen rich fuel gas via on-pot method using microwave heating. The adsorption data indicate that RB adsorption behavior follows the Langmuir model with the maximum adsorption capacity of 265.96 mg/g, whereas the adsorption kinetics follows the pseudo-second-order model. Thermodynamic calculations indicate that RB adsorption on CSA is spontaneous and endothermic process. The adsorption data are fitted to the Thomas and Yoon-Nelson model to predict the breakthrough curve in the column experiment. The RB removal could still be maintained at 71.22% of the original value after five cycles, demonstrating the reusability of CSA. GW2580 The chemical functional groups, electrostatic interaction, and pore filling of CSA are found to be responsible for high RB adsorption capability. CSA exhibits excellent RB removal efficiency in treating actual water. The major components of byproduct gases collected from activation process are H2 and CO.An elderly male presented with complaint of dull aching pain in left upper abdomen of 2 months' duration. He was well built, and on abdominal examination, a large lump was palpable in left lumbar region. His biochemical, hematological parameters and tumor markers including CA 19.9 were within prescribed normal limits. Contrast enhanced computed tomography (CT) of the abdomen revealed large, well-defined, mixed solid, and cystic lesion arising from distal body-tail of the pancreas extending up to splenic hilum. Chronic thrombosis involving retro pancreatic splenic vein with multiple perisplenic, peripancreatic, and perigastric collaterals were noted. Based on characteristic CT abdomen findings, a diagnosis of solid pseudopapillary tumor (SPT) of the pancreas with sinistral portal hypertension (SPH) was made. The patient was planned for open distal pancreatectomy with splenectomy. At surgery, splenic flexure of colon was densely adhered to the tumor, and hence en bloc resection of colon was also performed. Postoperative period was uneventful, and he was discharged from the hospital on postoperative day 6.