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2%) FDG PET/computed tomography answered correctly. On leaflet information, 15/85 (17.6%) patients reported the leaflets do not provide enough information on radiation exposure and of these 10/15 (66.7%) commented the leaflets should incorporate more information on radiation exposure dose. CONCLUSION More observational and qualitative studies in collaboration with patients are warranted to evaluate patients' understanding and preferences in communication of radiation exposure from nuclear medicine imaging. This will ensure communication tools and guidelines developed to comply with ionising radiation (medical exposure) regulation 2017 are according to patients needs and preferences.OBJECTIVES A single nucleotide polymorphism (SNP), rs5758550, in a critical enhancer region downstream of the CYP2D6 promoter was proposed to modulate CYP2D6 activity, depending on its linkage disequilibrium (LD) with the common CYP2D6 SNP, rs16947. We examined the influence of individual biogeographical ancestry on the frequency distribution of rs5758550 and its LD with rs16947 in Latin American populations. We then inferred the impact of rs5758550 on the predictive accuracy of CYP2D6 metabolizer status based on CYP2D6 haplotypes. METHODS The study cohorts consisted of the Admixed American (AMR) superpopulation of the 1000 Genomes Project (n = 347) plus an admixed Brazilian (BR) cohort (N = 224). Individual proportions of Native, African and European ancestry estimated by ADMIXTURE analysis, were used to design four sub-cohorts, in which one of the three ancestral roots predominated largely (>6 fold) over the other two AMR-NAT and AMR-EUR, comprised 80 AMR individuals each, with >70% Native or >70% European ing haplotypes with or without inclusion of rs5758550, showed that knowledge of the rs5758550 genotype has negligible impact on predicted CYP2D6 phenotypes in AMR-EUR and AMR-NAT, but affects prediction in 10.7 and 21.6% of BR-EUR and BR-AFR individuals, respectively. CONCLUSION Collectively, the present results reveal potential pharmacogenomic (PGx) implications of the population diversity in Latin America, affecting a major drug-metabolizing pathway. Thus, the influence of enhancer rs5758550 on assignment of CYP2D6 metabolic phenotypes varies markedly, according to the individual proportions of Native, European and African ancestry. This conclusion reinforces the notion that extrapolation of PGx data across the heterogeneous Latin American is risky, if not inappropriate.BACKGROUND AND OBJECTIVES Pharmacogenomics (PGx) is the use of human genomic information to avoid toxicity and optimize efficacy of drug therapy in an individual. Hospital pharmacists are the key persons to facilitate the incorporation of PGx into clinical practice. PGx is relatively new to Thai hospital pharmacists. Therefore, this study aimed to evaluate the knowledge, attitude, and practice of Thai hospital pharmacists towards PGx implementation. MATERIALS AND METHODS We conducted a cross-sectional questionnaire-based survey among 600 hospital pharmacists in 21 hospitals across Thailand. The questionnaire consisted of 35 questions using comment boxes, Likert scales, and multiple choice answers. RESULTS The response rate was 20.5% (n = 123). Nearly half of the hospital pharmacists (46.3%) had low PGx knowledge score ( less then 5 points), particularly for applied PGx knowledge in clinical situations. Concerns regarding PGx reimbursement, privacy issues, and discrimination were mentioned in this survey. However, most hospital pharmacists had positive attitude towards PGx service. Only 7% of hospital pharmacists had recommended or interpreted PGx tests in the past year. National PGx guidelines and government policies were considered the important factors for PGx implementation. Moreover, the most preferred learning format for PGx education was professional academic conferences. CONCLUSION Hospital pharmacists in Thailand had positive attitude towards PGx, despite limited experience and practice of PGx. PGx education to support an application of PGx knowledge in clinical situations is required. National PGx guidelines and government policies may need to be developed to address the concerns for reimbursement, privacy, and discrimination to ensure successful PGx implementation.Ferrari, L, Colosio, AL, Teso, M, and Pogliaghi, S. Performance and anthropometrics of classic powerlifters which characteristics matter? J Strength Cond Res XX(X) 000-000, 2020-The purpose of this study is (a) provide normative performance and anthropometric data of Southern European classic powerlifters of both sexes; (b) determine the possible relationships between these variables and performance; and (c) develop population-specific predictive equations for single lifts and overall powerlifting performance. During an unofficial national-level competition, we recruited 74 athletes (51 men and 23 women) and recorded their individual, anthropometric, and performance characteristics and divided them into sex and 2 performance categories based on their Wilks points. Weaker (370 Wilks points) athletes of both sexes were compared by two-way analysis of variance. Tezacaftor in vivo Simple correlation and multiple linear regression between individual/anthropometric characteristics and performance were modeled. We applied a step-forward multiple linear regression model to predict single lifts and overall performance. All parameters significantly differed between sexes (p less then 0.05 for all comparisons). Stronger male athletes had a significantly larger neck (42 ± 2.8 cm; effect size [ES] = 0.59), and flexed (40.6 ± 3.3 cm; ES = 1.18) and relaxed upper-arm (37.5 ± 3.1 cm; ES = 1.34) and thigh girths (63.6 ± 7.0 cm; ES = 0.77) compared to weaker male athletes. Furthermore, stronger women had significantly larger flexed (32.6 ± 3.3 cm; ES = 0.88) and relaxed upper-arm (33 ± 1.5 cm; ES = 2.28) and chest girths (99.3 ± 9.2 cm; ES = 1.10) compared to weaker female athletes. A combination of experience, fat mass, and upper-limb and lower-limb muscle mass indexes can accurately and precisely predict overall and individual lift performance (r ≥ 0.83 for all the predictions). This is the first study to provide normative performance and anthropometric data in Southern European male and female powerlifters.