Vangburt4335

In order to meet the increasing demand of integration and miniaturization of electronic components, capacitors with high energy density are urgently needed. In this work, a strategy of suppressing interfacial polarization for obtaining enhanced energy density and efficiency polymer based nanocomposites is proposed. This strategy is conducted by epitaxial growth of a SrTiO3 layer with a moderate dielectric constant on the surface of a BaTiO3 core to form a kind of novel filler and compositing with the P(VDF-HFP) matrix to prepare dielectric nanocomposites. Epoxomicin The SrTiO3 shell could effectively confine the mobility of charge carriers to enhance the dielectric strength of the composites and improve the energy efficiency by reducing the Maxwell-Wagner-Sillars (MWS) interfacial polarization and space charge polarization between the BaTiO3@SrTiO3 fillers and the P(VDF-HFP) matrix due to their similar crystal structure and lattice parameter. The nanocomposite containing 1 vol% BaTiO3@SrTiO3 nanoparticles achieved a discharged energy density of 13.89 J cm-3 and an energy efficiency of 63% at 494.7 kV mm-1, which are superior to 9.96 J cm-3 and 50% of BaTiO3/P(VDF-HFP) nanocomposites with the same loading, respectively, and its discharged energy density is 69% higher than 8.2 J cm-3 of the neat P(VDF-HFP) at 401.5 kV mm-1. This work provides an effective way for nanocomposite capacitors with high energy density and efficiency.Obesity has become an international public health problem. In this study, an obese mice diet was supplemented with raw rice bran (RRB) or infrared radiation-stabilized rice bran (IRRB) to investigate the attenuation of obesity induced by a high-fat diet. Mice were fed a normal diet or a high-fat diet with and without rice bran supplementation (300 mg per kg body weight per day) by oral gavage for 39 days to investigate the obesity preventive effect. The results indicate that different rice bran supplements reduced body weight, relative adipose tissue weight, inflammation, and serum parameters, and relieve liver steatosis to varying degrees. The data of real-time qPCR and western blots (WB) showed that rice bran activated brown adipose tissue (BAT) and increased white adipose tissue (WAT) browning. Rice bran also reduced the ratio of Firmicutes/Bacteroidetes and enhanced the relative abundance of Akkermansia. In summary, our findings suggest that rice bran intervention played a significant role in reducing dyslipidemia, alleviating inflammation, enhancing thermogenesis and modulating gut microbiota for the prevention and control of obesity.Electrochemistry provides possibilities to realize smart microdevices of the next generation with high functionalities. Electrodes, which constitute major components of electrochemical devices, can be formed by various microfabrication techniques, and integration of the same (or different) components for that purpose is not difficult. Merging this technique with microfluidics can further expand the areas of application of the resultant devices. To augment the development of next generation devices, it will be beneficial to review recent technological trends in this field and clarify the directions required for moving forward. Even when limiting the discussion to electrochemical microdevices, a variety of useful techniques should be considered. Therefore, in this review, we attempted to provide an overview of all relevant techniques in this context in the hope that it can provide useful comprehensive information.Drug-induced gastrointestinal toxicities (DI-GITs) are among the most common adverse events in clinical trials. High prevalence of DI-GIT has persisted among new drugs due in part to the lack of robust experimental tools to allow early detection or to guide optimization of safer molecules. Developing in vitro assays for the leading GI toxicities (nausea, vomiting, diarrhoea, constipation, and abdominal pain) will likely involve recapitulating complex physiological properties that require contributions from diverse cell/tissue types including epithelial, immune, microbiome, nerve, and muscle. While this stipulation may be beyond traditional 2D monocultures of intestinal cell lines, emerging 3D GI microtissues capture interactions between diverse cell and tissue types. These interactions give rise to microphysiologies fundamental to gut biology. For GI microtissues, organoid technology was the breakthrough that introduced intestinal stem cells with the capability of differentiating into each of the epithelial cide perspective on the assay features needed for MPS models to be adopted for DI-GIT assessment.Docosahexaenoic acid (DHA) was encapsulated in caseinate/alginate microparticles by adjusting the pH based on the electrostatic complexation, in order to improve the physicochemical stability and digestibility of single caseinate-stabilized DHA emulsions. In this study, relatively stable honeycomb-shaped DHA microparticles were formed by electrostatic complexation between positively charged caseinate-coated DHA droplets, caseinate and negatively charged alginate at pH 4.5. The zeta-potential, particle size, size distribution, physical stability, microstructure, DHA oxidation and free fatty acids (FFA) release rate in a simulated gastrointestinal tract (GIT) model were determined. Dynamic light scattering (DLS) and confocal laser scanning microscopy (CLSM) measurements indicated that DHA microparticles had a particle size (1521.00 ± 39.15 nm) significantly larger than that of caseinate-stabilized DHA emulsions (243.23 ± 4.51 nm). The microparticles were much more stable near the isoelectric point (pI) of the adsorbed proteins compared with the single emulsions according to the original transmissions of LUMiSizer. The cryo-scanning electron microscopy (Cryo-SEM) images also showed that the microparticles formed a specific honeycomb-shaped network structure with more uniform distribution and without aggregation. The incorporation of DHA droplets into caseinate/alginate microparticles significantly ameliorated their chemical stability. GIT studies showed that the digestion of DHA microparticles was enhanced which was due to more open loose structures compared with the large-scale close-knit aggregation of DHA emulsion droplets. This study may provide useful information for the stabilization of functional food components and rational design of nutraceutical delivery systems.