Aliholman5350

specific for each country. The third part of the logistic regression analysis suggested that the country residual was highly statistically significant. This indicates that there are some statistically significant differences with respect to the characteristics of the two regional datasets used in the analysis.Several factors can influence driver behaviour, and road geometry is one of them. A better understanding of driver-roadway interaction can enhance road design to create a safer traffic system. In this context, driving simulators are powerful tools that combine convenience and effectiveness in identifying drivers' responses to different geometry factors. In this paper, a systematic review following a Prisma guideline was conducted on driving simulator studies that examined the effects of road geometry on driver behaviour to reveal the current procedures adopted in this field and their main findings. A systematic search of eleven databases was performed covering six years of research results. Inclusion of relevant studies focused on horizontal curves, a topic identified as the most cited, extended this period. The results revealed significant heterogeneity in relation to the measured variables and deficiencies when reporting the experiment, which prevented a meta-analysis of the studies' outcomes. Despite this, a discussion of the potential of driving simulators to contribute to several road safety research gaps is presented. In addition, problems of a lack of standardisation in the performance of the experiments were detected, potentially influencing the findings of the studies. However, the results also suggest that experiments that followed good experimental practices observed effects on driver performances not detected by other studies.Traffic safety devices are one of the most important tools used to improve safety in tunnels. The tunnel retro-reflective arch (TA) plays a crucial role in stimulating drivers, relieving visual stress, and improving safety. However, determining the TA spacing mostly relies on experience and relevant standards are lacking. The aim of this research was to evaluate the degree of influence of the TA on driver behavior, visual aspects, and psychology in different zones (overall tunnel, curved segment, and middle segment) of extra-long tunnels. To test the influence of TAs, four scenarios were constructed, including three alternatives with different TA spacings (200, 300, and 400 m), and one no-arch design as a control alternative. Based on a driving simulator, the evaluation indicators related to driving safety, smoothness, and handling stability were selected and analyzed. We acquired data every 50 m as an analytical unit. The results show that the TA significantly affects driver behavior, visual aspects, and psychology. According to the matter-element model result, setting the TA spacing to 300 m in curved segment and in the tunnel overall is the best option. In the middle segment, the setting spacing of 400 m is ideal.

Neuromyelitis optica spectrum disorder (NMOSD) is a rare autoimmune astrocytopathy that affects several regions of the central nervous system (CNS) with a predilection for the optic nerves and spinal cord. Epidemiological studies of NMOSD are uncommon in the Middle East and up-to-date, there are no such data from Saudi Arabia. In this study, we aim to study the clinical pattern of NMOSD patients in Saudi Arabia.

A retrospective multi-center observational study was conducted at King Abdulaziz Medical City in Jeddah and Riyadh, Saudi Arabia. The inclusion criteria consisted of all the patients with either neuromyelitis optica according to the 2006 criteria or NMOSD according to the 2015 criteria. The study period was 20 years.

A total of 23 patients were included in the study. Deutenzalutamide Four were males (17.4%) and 19 were females (82.6%). The attack type was optic neuritis in 3 patients (13.0%), transverse myelitis in 15 patients (65.2%), and both in 5 patients (21.7%). All patients (100%) received pulse steroid thased number of diagnosed cases. In addition, there is no registry for this disorder with only a few specialized centers dealing with its management. It is time to establish specialized demyelinating disease centers and build expertise in both common and rare diseases in this category.The use of biological traces recovered from touched or handled items increased with the advance of the forensic analysis system. Thus, DNA profiles obtained from touch DNA became a useful tool in forensic investigation. However, a chimeric person with more than one chromosomal population can be challenging for a forensic analyst. We investigated the genetic profile in blood, buccal swab, and skin swabs from twenty-four recipients aged 21-63 years who underwent a matched sibling allogeneic hematopoietic stem cell transplantation with no sign of skin graft versus host disease. Autosomal short tandem repeats genotyping was performed to evaluate chimerism status at 15 loci along with gender marker Amelogenin. According to our results, donor chimerism was detected in all recipient's blood samples, while in buccal swabs, five recipients showed no presence of donor-derived cells in their genotype. Epithelial cells swabbed from hand fingertips were not devoid of donor-derived cells since all recipients showed high chimerism (39.69%-96.66%) in their genotypes. A significant change in chimerism was seen among various types of biological samples (p 0.05). The loci D21S11, D8S1179, and FGA were the most informative, whereas D13S317, Vwa, and TOPX were the least informative STR markers. We concluded that touch DNA from a person who has undergone a successful allogeneic HSCTs should not be considered as reliable evidence for human identifications. Therefore, necessary precautions must be taken to avoid false identification and miscarriage of justice.The underlying physics in bloodstain formation on fabrics is not well understood, despite its importance in bloodstain pattern analysis (BPA). This paper presents a fundamental study of the formation of drip bloodstains on fabrics, by focusing on blood droplet impact and wicking dynamics. The bloodstains were created on plain woven fabric by the perpendicular impact of a single blood drop with seven different impact velocities. The whole droplet impact and wicking processes were captured by multiple cameras. Fabric properties were characterized in detail at different levels. The bloodstain formation process was classified into distinct stages, including the inertial impact, initial absorption, first wicking and second wicking stages. The subsequent wicking process greatly alters the impact-induced bloodstains, in terms of bloodstain area. The dimensionless impact-induced stain factor (βi,e) is strongly dependent on the impact velocity while the final stain factor (βf,e) after the second wicking stage is not. The contribution of the subsequent wicking in altering the stain factor (or stain area) is quantified and found to decrease with increasing impact velocity.