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05). Gender, age, body mass index, and co-morbidities were compared with the severity of the disease; no statistically significant difference was found.

Viral load detected in saliva in the early period of COVID-19 infection may have a prognostic value in showing the disease's course in patients over 45-year-old. Saliva is an easily obtainable, reliable material for COVID-19 screening.

Viral load detected in saliva in the early period of COVID-19 infection may have a prognostic value in showing the disease's course in patients over 45-year-old. Saliva is an easily obtainable, reliable material for COVID-19 screening.

To examine whether children with brain tumors treated with resection benefit from inpatient rehabilitation and to explore what factors present at admission may predict better functional outcomes.

Retrospective cohort design.

Pediatric inpatient rehabilitation unit.

Forty patients (N=40; ages 3-21y; 42.5% female) admitted to the rehabilitation unit between 2003 and 2015 after brain tumor resection.

Patients received multidisciplinary rehabilitation therapies as part of their admission to inpatient rehabilitation, including occupational, physical, and speech-language therapy.

Functional outcomes included the FIM for Children (WeeFIM) at discharge and 3-month follow-up as well as WeeFIM efficiency.

A repeated-measures analysis of variance using patient WeeFIM Developmental Functional Quotients (DFQs) at admission, discharge, and 3-month follow-up showed significant gains in total WeeFIM DFQ scores across time. Admission WeeFIM DFQ, time from surgery to admission, and age at admission provided the sIM) during inpatient rehabilitation and continued to make significant gains 3 months after discharge. Age and timing of admission provided the strongest models for predicting patient outcomes. The NPS did not predict functional outcomes after rehabilitation when controlling for other variables known to influence rehabilitation outcomes.

Evaluate physical activity (PA) and sedentary behavior and their associations with symptom and quality of life outcomes in adults with persistent post-concussive symptoms (PPCS) following mild traumatic brain injury (mTBI).

Cross-sectional cohort study.

Outpatient brain injury clinic.

Consecutive sample of adults (n=180) with a diagnosis of mTBI and PPCS.

Not applicable.

PA and sedentary behavior were assessed using the Godin Leisure-Time Exercise Questionnaire and Rapid Assessment Disuse Index, respectively. Participants were dichotomized according to whether they completed 150 minutes of moderate-to-vigorous PA per week, based on Canadian guidelines. Post-injury moderate-to-vigorous PA was also analyzed as a continuous variable.

Prior to injury, 85% of participants reported meeting PA guidelines, compared to 28% post-injury. Individuals meeting PA guidelines post-injury reported higher quality of life (η



=0.130, p<0.001) and lower scores on measures of functional impact of headache (η



=0.065, p=0.009), fatigue (η



=0.080, p=0.004), depression (η



=0.085, p=0.001) and anxiety (η



=0.046, p=0.031), compared to those not meeting guidelines. Sedentary behavior post-injury was negatively correlated with quality of life (r

(127)= -0.252, p=0.004) and positively correlated with symptom burden (r

(167)=0.227, p=0.003), fatigue (r

(127)=0.288, p=0.001), depression (r

(174)=0.319, p<0.001) and anxiety (r

(127)=0.180, p=0.042).

PA was significantly decreased in individuals with PPCS compared to pre-injury levels. Meeting PA guidelines post-injury was associated with better clinical outcomes, suggesting that returning individuals to PA should be considered in the treatment of this patient population.

PA was significantly decreased in individuals with PPCS compared to pre-injury levels. Meeting PA guidelines post-injury was associated with better clinical outcomes, suggesting that returning individuals to PA should be considered in the treatment of this patient population.Ischemic stroke is a leading cause of disability world-wide. Mounting evidence supports neuromuscular pathology following stroke, yet mechanisms of dysfunction and therapeutic action remain undefined. The objectives of our study were to investigate neuromuscular pathophysiology following ischemic stroke and to evaluate the therapeutic effect of Robot-Assisted Mechanical massage Therapy (RAMT) on neuromuscular junction (NMJ) morphology. Using an ischemic stroke model in male rats, we demonstrated longitudinal losses of muscle contractility and electrophysiological estimates of motor unit number in paretic hindlimb muscles within 21 days of stroke. Histological characterization demonstrated striking pre- and postsynaptic alterations at the NMJ. Stroke prompted enlargement of motor axon terminals, acetylcholine receptor (AChR) area, and motor endplate size. Paretic muscle AChRs were also more homogenously distributed across motor endplates, exhibiting fewer clusters and less fragmentation. Most interestingly, NM Following ischemic stroke in a rat model, there are progressive declines of motor unit number estimates and muscle contractility. Miransertib solubility dmso These changes are paralleled by striking pre- and postsynaptic maladaptive changes at the neuromuscular junction, including polyaxonal innervation. When administered to paretic hindlimb muscle, Robot-Assisted Mechanical massage Therapy - previously shown to improve motor function and protect against subacute myokine disturbance - prevents stroke-induced neuromuscular junction alterations. These novel observations provide insight into the neuromuscular response to cerebral ischemia, identify peripheral mechanisms of functional disability, and present a therapeutic rehabilitation strategy with clinical relevance.The persistence of attentional set from one task to a secondary unrelated task, revealed through carryover of eye movements, has been attributed to increased activation in the parietal lobe and decreased activation to the frontal lobe. To directly test this, we adopted a modified version of the Thompson and Crundall (2011) paradigm using low-frequency repetitive TMS to P3 and F3. In each trial, participants viewed letter-strings that were arranged horizontally, vertically, or randomly across the screen before viewing a road image and providing a hazardousness rating for it. The orientation of the letter search influenced eye movements to the road images and this carryover was greater following stimulation to F3 than to P3 (or sham). Furthermore, hazardous ratings were lower following P3 stimulation. These results confirm the involvement of attentional orienting and switching mechanisms in the carryover of eye movements. It is suggested that this "attentional inertia" effect will increase with greater orienting of attentional resources in an initial task and poor inhibition of previously-relevant settings between tasks.