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in English, French La survenue d’un diabète après transplantation rénale est une entité fréquemment rencontrée tant par le néphrologue, le diabétologue que par le médecin de premier recours. Cet article fait le point sur différents aspects liés au diabète après transplantation rénale tels que l’épidémiologie, les facteurs de risque, la pathogenèse, le diagnostic, les complications associées et la prise en charge thérapeutique.in English, French L’éthylène glycol (EG), bon marché et facile d’accès, est notamment utilisé dans la synthèse des antigels. Une intoxication à l’EG a des conséquences morbides potentiellement irréversibles et est associée à une mortalité non négligeable. Du fait des complications et de sa distribution en libre-service, il convient pour le praticien des urgences d’en reconnaître les manifestations, notamment métaboliques, afin d’en assumer le traitement en partenariat avec l’intensiviste et le néphrologue. Le succès dépend d’une reconnaissance rapide et d’une prise en charge multidisciplinaire dont une approche est suggérée dans cet article.in English, French Récemment, la compréhension des mécanismes immuns impliqués dans la réponse antitumorale a permis de développer de nouveaux traitements oncologiques, les inhibiteurs de points de contrôle immunitaires. L’action de ceux-ci repose sur une rupture des mécanismes de tolérance immune envers la tumeur. Avec leur développement, on observe l’apparition d’effets indésirables d’un nouveau genre, s’apparentant à une autoimmunité et touchant différents systèmes. La toxicité rénale, sous la forme d’une néphrite tubulo-interstitielle, est une complication encore méconnue mais émergeante.in English, French Lors de l’initiation d’un traitement d’hémodialyse chronique, l’hémodialyse incrémentale prend en compte la fonction rénale résiduelle (FRR) du patient et complète celle-ci par une dose de dialyse pour atteindre un niveau d’épuration et d’ultrafiltration satisfaisant. Cela permet d’effectuer des séances d’hémodialyse qui sont plus courtes et moins intenses ou moins fréquentes que la prescription standard de 3 dialyses par semaine. Cette méthode est associée à de multiples bénéfices pour le patient. Néanmoins, la FRR doit être monitorée régulièrement afin d’adapter la dose de dialyse et d’éviter une sous-dialyse.in English, French La dialyse péritonéale (DP) a souvent été considérée à tort comme inadaptée à la population âgée, qui représente la majorité des patients en insuffisance rénale terminale. De nombreuses études ont montré que cette méthode est très bien, voire mieux tolérée que l’hémodialyse par les personnes âgées. Son aspect économique est de plus en plus mis en avant en Suisse et à l’étranger. Alors que la DP représentait longtemps less then 10 % de la population dialysée, nous observons ces dernières années une hausse de patients traités par cette méthode. Par conséquent, le médecin traitant et l’interniste hospitalier seront plus fréquemment confrontés à ces patients. Ceci nécessite des bonnes notions de base de cette modalité comme discuté dans cet article.BACKGROUND Late-onset Pompe disease (LOPD) is a genetic disorder characterized by progressive degeneration of the skeletal muscles produced by a deficiency of the enzyme acid alpha-glucosidase. Enzymatic replacement therapy with recombinant human alpha-glucosidase seems to reduce the progression of the disease; although at the moment, it is not completely clear to what extent. Quantitative muscle magnetic resonance imaging (qMRI) is a good biomarker for the follow-up of fat replacement in neuromuscular disorders. The aim of this study was to describe the changes observed in fat replacement in skeletal muscles using qMRI in a cohort of LOPD patients followed prospectively. METHODS A total of 36 LOPD patients were seen once every year for 4 years. qMRI, several muscle function tests, spirometry, activities of daily living scales, and quality-of-life scales were performed on each visit. Muscle MRI consisted of two-point Dixon studies of the trunk and thigh muscles. Computer analysis of the images provided the peudy identifies that skeletal muscle fat fraction continues to increase in patients with LOPD despite the treatment with enzymatic replacement therapy. These results suggest that the process of muscle degeneration is not stopped by the treatment and could impact muscle function over the years. Hereby, we show that fat fraction along with muscle function tests can be considered a good outcome measures for clinical trials in LOPD patients. © 2020 The Authors. Journal of Cachexia, Sarcopenia and Muscle published by John Wiley & Sons Ltd on behalf of Society on Sarcopenia, Cachexia and Wasting Disorders.A needle-type microrobot (MR) for targeted drug delivery is developed to stably deliver drugs to a target microtissue (MT) for a given period time without the need for an external force after affixing. The MRs are fabricatedby 3D laser lithography and nickel (Ni)/titanium oxide (TiO2 ) layers are coated by physical vapor deposition. The translational velocity of the MR is 714 µm s-1 at 20 mT and affixed to the target MT under the control of a rotating magnetic field. The manipulability of the MR is shown by using both manual and automatic controls. Finally, drug release from the paclitaxel-loaded MR is characterized to determine the efficiency of targeted drug delivery. This study demonstrates the utility of the proposed needle-type MR for targeted drug delivery to MT with various flow rates in vitro physiological fluidic environments. © 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.AIM Thought disorder is a core feature of schizophrenia but assessment of disordered thinking is challenging, which may contribute to the paucity of mechanistic understanding of disorganization in early psychosis. We studied the use of linguistic connectives in relation to clinically quantified dimensions of thought disorder using automated speech analysis in untreated, first episode psychosis (FEPs) and healthy controls (HCs). METHODS 39 treatment-naïve, actively psychotic FEPs and 23 group matched HCs were recruited. Three one-minute speech samples were induced in response to photographs from the Thematic Apperception Test and speech was analysed using COH-METRIX software. Five connectives variables from the Coh-Metrix software were reduced using principle component analysis, resulting in two linguistic connectives factors. Thought disorder was assessed using the Thought Language Index (TLI) and the PANSS-8. RESULTS Connective factors predicted disorganization, but not impoverishment suggesting aberrant use of connectives is specific to positive thought disorder. An independent t test comparing low and high disorganization FEPs showed higher load of acausal temporal connectives in high disorganization FEPs compared to low disorganization FEPs (mean [SD] in high vs low disorganization FEPs = 0.64 (1.1) vs -0.37 (1.02); t = 2.91, P = .006). Acausal-temporal connectives were not correlated with severity of symptoms or cognition suggesting connective use is a specific index of disorganized thinking rather than overall illness status. CONCLUSIONS Clinical assessment of disorganization in psychosis is likely linked to the aberrant use of connectives resulting in an intuitive sense of incoherence. In early psychosis, thought disorder may be reliably quantifiable using automated syntax analysis. © 2020 John Wiley & Sons Australia, Ltd.INTRODUCTION Recent studies report that syncope is not a significant predictor of 30-day mortality in pulmonary embolism (PE) patients, yet some data suggest sex-related differences may be relevant. OBJECTIVES To evaluate sex-specific prediction significance of syncope for 30-day mortality in PE patients. METHODS A multicentric, retrospective, observational, registry-based study on consecutive PE patients was undertaken. Patients were allocated into either a men or a women group before comparisons were made between patients with syncope and those without syncope. A sex-related prediction of the significance of syncope for 30-day mortality was evaluated. selleck RESULTS Overall 588 patients [294 (50%) men and 294 (50%) women] were included within the study. Among men, patients with syncope were older and had significantly higher parameters of increased 30-day mortality then patients without syncope. Within the same group, however, difference in the 30-day mortality rate was not significant (log rank P = .942). In contrast to the men, fewer differences in admission characteristics were noticed among women, but those with syncope had significantly increased signs of the right ventricular dysfunction and increased 30-day mortality rate, as compared with those without syncope (log rank P = .025). After adjustment for age in a Cox regression analysis, syncope was a significant predictor of 30-day mortality in women (HR = 2.01, 95%CI 1.02-3.95). CONCLUSION Although syncope is associated with other predictors of higher early mortality in both male and female PE patients, only in women it is a significant predictor of 30-day mortality. © 2020 John Wiley & Sons Ltd.BACKGROUND The aim of this study was to examine the trends in the mortality rate and years of life lost (YLL) rate of lung cancer in Tianjin, China, during the period from 1999 to 2016. METHODS Lung cancer death data were obtained from Tianjin residents' all-cause death monitoring system, which covers the whole population of Tianjin. Crude mortality rate, age-standardized mortality rate, truncated rate (35-64 years), YLL and age-standardized YLL rate data were calculated and trends examined. RESULTS From 1999 to 2016, a total of 93 358 lung cancer deaths were reported in Tianjin, which accounted for 38.0% of all cancer deaths (93 358/245744). The crude mortality rate of lung cancer had increased 58.5% from 1999 (40.15/100000) to 2016 (63.64/100000), average annual percent change (AACP) = 2.9%, P  less then  0.01. However, the age-standard YLL rate had decreased to 13.3% in 2016 than in 1999, AACP = -0.8%, P  less then  0.01, with a stable trend in males (AACP = -0.2%), and noticeable decreasing trend in females (AACP = -1.4%). The lung cancer mortality rate (ASRW) in urban areas was higher than that in rural areas in 1999, with a ratio of 1.991. However, it was lower in 2016, with the ratio of 0.981. For the truncated rate (35-64 years), it had decreased in urban areas compared with rural areas since the year 2013. CONCLUSION Lung cancer remains the most fatal cancer in Tianjin. However, the age-standard YLL rate of lung cancer has decreased considerably accompanied by a decline in smoking rate years ago, especially in women and people living in urban areas. Considerable attention is therefore needed in the rural areas where cases of lung cancer are still rapidly increasing. © 2020 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.Photoelectrochemical (PEC) water splitting using visible-light-responsive photoelectrodes is the preferred approach to converting solar energy into hydrogen as a renewable energy source. A transparent Ta3 N5 photoanode embedded within a PEC cell having a tandem configuration is a promising configuration that may provide a high solar-to-hydrogen energy conversion efficiency. Ta3 N5 thin films are typically prepared by heating precursor films in an NH3 flow at high temperatures, which tends to degrade the transparent conductive layer, such that producing efficient Ta3 N5 transparent photoanodes is challenging. Herein, the direct preparation of transparent Ta3 N5 photoanodes on insulating quartz substrates was demonstrated without the insertion of a transparent conductive layer. The resulting devices generated a photocurrent of 6.0 mA cm-2 at 1.23 V vs. a reversible hydrogen electrode under simulated sunlight. This study provides a new strategy for the preparation of transparent photoelectrodes that mitigates current challenges.