Kragknox5686

Conclusion 4 weeks of flywheel squat training in collegiate club water polo players elicited large gains (47-52%) in flywheel-specific squat power, but did not influence sport-specific performance measures including CMJ, WJH, and foot speed. Water-based exercises and stretch-shortening cycle movements (plyometrics) in combination with effective resistance training programs, which may include flywheel-based training, are likely needed for marked sport skill improvements.This study investigated the adsorption characteristics of the carbonaceous adsorbents for organic compounds in gas to gain technical knowledge useful for the appropriate operation and management of the incineration plants and industrial heat treatment facilities. The experiments in the study were performed using a dynamic method, employing a small column packed with test adsorbent, into which flowed the model gas, primarily over a temperature range of 150°C to 190°C. Three activated carbon materials and an activated coke were used, with specific surface areas ranging from 250 to 1,100 m2/g-adsorbent. Organic components in the gas were produced and supplied at a concentration of tens of mg/m3, and gaseous mercury was supplied at a concentration of around 100 μg/m3. The experimental results showed the following 1) The adsorption capacity of every carbonaceous material for organic vapor decreased with increasing temperature, with roughly a three-fold difference in the capacity, between 150°C and 190°C in the dry gas. The equilibrium adsorption amount of benzene could be estimated based on the specific surface area of the adsorbent. 2) Gas moisture reduced the equilibrium adsorption amount of adsorbates by about half. 3) The estimation of the treatment performance for actual adsorption processing suggested the possibility of decreased removal efficiency at higher temperatures above 175°C. Overall, the precise process design should be made based on future practical studies.Implications Adsorptive characteristics of activated carbon materials were examined for benzene and chlorobenzene in gas within the temperature range of 150°C to 190°C.The adsorption amount of benzene at high temperature and low concentration range below 20 ppm was in the range of 103 to 104 mg/kg-adsorbent.There was a clear difference between the adsorption parameters of activated carbon and coke for the benzene adsorption, depending on their specific surface area values and other factors.Natural manipulation tasks in air consist of two kinematic components a grasping component, with activation of the hand muscles, and a lifting component, with activation of the proximal muscles. However, it remains unclear whether the synchronized motor commands to the hand/proximal arm muscles are divergently controlled during the task. Therefore, we examined how intermuscular coherence was modulated depending on the muscle combinations during grip and lift (G&L) tasks. Electromyograms (EMGs) were recorded from the biceps brachii (BB), triceps brachii (TB), flexor digitorum superficialis (FDS), and extensor digitorum communis (EDC) muscles. The participants were required to maintain G&L tasks involving a small cubical box with the thumb and index and middle fingers. Consequently, we found that the beta-rhythm coherence (15-35 Hz) in BB-TB, BB-FDS, and TB-EDC pairs during G&L was significantly larger than that during the isolated task with cocontraction of the two target muscles but not BB-EDC, TB-FDS, and FDdepending on the hand/proximal muscle pairs and that the multiple combination effect of the sensations of touch/object load and motor signals in the task promotes the synchrony of these pairs.The bivariate Stable Trait, AutoRegressive Trait, and State (STARTS) model provides a general approach for estimating reciprocal effects between constructs over time. However, previous research has shown that this model is difficult to estimate using the maximum likelihood (ML) method (e.g., nonconvergence). In this article, we introduce a Bayesian approach for estimating the bivariate STARTS model and implement it in the software Stan. We discuss issues of model parameterization and show how appropriate prior distributions for model parameters can be selected. Specifically, we propose the four-parameter beta distribution as a flexible prior distribution for the autoregressive and cross-lagged effects. Using a simulation study, we show that the proposed Bayesian approach provides more accurate estimates than ML estimation in challenging data constellations. An example is presented to illustrate how the Bayesian approach can be used to stabilize the parameter estimates of the bivariate STARTS model.Background. The number of mobile health applications is rapidly increasing, yet no reliable tool exists for occupational therapists and their clients to rate the quality of these apps. Purpose. To develop the Alberta Rating Index for Apps (ARIA). Methods. Through a sequential design in three phases, we developed a rating index for mobile health applications and examined its reliability and validity with 10 participants. Findings. The coefficients of reliability were 0.95 for occupational therapists, 0.60 for older adults, and 0.88 for adults with a mental health condition. ARIA's correlation with another scale used in app review studies, U-MARS, was low to moderate. Implications. ARIA showed a high inter-rater reliability in two of the three user groups. ARIA is comprehensive and includes criteria not captured by U-MARS, such as privacy and security. Further studies are warranted with diverse raters and health apps.Humans will set foot on the Moon again soon. The lunar dust (LD) is potentially reactive and could pose an inhalation hazard to lunar explorers. We elucidated LD toxicity and investigated the toxicological impact of particle surface reactivity (SR) using three LDs, quartz, and TiO2. We first isolated the respirable-size-fraction of an Apollo-14 regolith and ground two coarser samples to produce fine LDs with increased SR. SR measurements of these five respirable-sized dusts, determined by their in-vitro ability to generate hydroxyl radicals (•OH), showed that ground LDs > unground LD ≥ TiO2 ≥ quartz. Rats were each intratracheally instilled with 0, 1, 2.5, or 7.5 mg of a test dust. Toxicity biomarkers and histopathology were assessed up to 13 weeks after the bolus instillation. All dusts caused dose-dependent-increases in pulmonary lesions and toxicity biomarkers. The three LDs, which possessed mineral compositions/properties similar to Arizona volcanic ash, were moderately toxic. Despite a 14-fold •OH difference among these three LDs, their toxicities were indistinguishable. Quartz produced the lowest •OH amount but showed the greatest toxicity. Our results showed no correlation between the toxicity of mineral dusts and their ability to generate free radicals. We also showed that the amounts of oxidants per neutrophil increased with doses, time and the cytotoxicity of the dusts in the lung, which supports our postulation that dust-elicited neutrophilia is the major persistent source of oxidative stress. These results and the discussion of the crucial roles of the short-lived, continuously replenished neutrophils in dust-induced pathogenesis are presented.Mechanisms of rhythm generation have been extensively studied in motor systems that control locomotion over terrain in limbed animals; however, much less is known about rhythm generation in soft-bodied terrestrial animals. Here we explored how muscarinic acetylcholine receptor (mAChR)-modulated rhythm-generating networks are distributed in the central nervous system (CNS) of soft-bodied Drosophila larvae. We measured fictive motor patterns in isolated CNS preparations, using a combination of Ca2+ imaging and electrophysiology while manipulating mAChR signaling pharmacologically. Bath application of the mAChR agonist oxotremorine potentiated bilaterally asymmetric activity in anterior thoracic regions and promoted bursting in posterior abdominal regions. Selleckchem Pyroxamide Application of the mAChR antagonist scopolamine suppressed rhythm generation in these regions and blocked the effects of oxotremorine. Oxotremorine triggered fictive forward crawling in preparations without brain lobes. Oxotremorine also potentiated rhythmic as) underlying headsweep behavior and forward locomotion. This provides new insights into locomotor CPG operation in soft-bodied animals that navigate over terrain.

Drug repurposing can be a successful approach to deal with the scarcity of cost-effective therapies in situations such as the COVID-19 pandemic. Tetracyclines have previously shown efficacy in preclinical acute respiratory distress syndrome (ARDS) models and initial predictions and experimental reports suggest a direct antiviral activity against SARS-CoV2. Furthermore, a few clinical reports indicate their potential in COVID-19 patients. In addition to the scarcity and limitations of the scientific evidence, the effectiveness of tetracyclines in experimental ARDS has been proven extensively, counteracting the overt inflammatory reaction and fibrosis sequelae due to a synergic combination of pharmacological activities.

This paper discusses the scientific evidence behind the application of tetracyclines for ARDS/COVID-19.

The benefits of their multi-target pharmacology and their safety profile overcome the limitations, such as antibiotic activity and low commercial interest. Immunomodulatory tetracyclines and novel chemically modified non-antibiotic tetracyclines have therapeutic potential. Further drug repurposing studies in ARDS and severe COVID-19 are necessary.

The benefits of their multi-target pharmacology and their safety profile overcome the limitations, such as antibiotic activity and low commercial interest. Immunomodulatory tetracyclines and novel chemically modified non-antibiotic tetracyclines have therapeutic potential. Further drug repurposing studies in ARDS and severe COVID-19 are necessary.When lifting an object skillfully, fingertip forces need to be carefully scaled to the object's weight, which can be inferred from its apparent size and material. This anticipatory force scaling ensures smooth and efficient lifting movements. However, even with accurate motor plans, weight perception can still be biased. In the size-weight illusion, objects of different size but equal weight are perceived to differ in heaviness, with the small object perceived to be heavier than the large object. The neural underpinnings of anticipatory force scaling to object size and the size-weight illusion are largely unknown. In this study, we tested the role of anterior intraparietal cortex (aIPS) in predictive force scaling and the size-weight illusion, by applying continuous theta burst stimulation (cTBS) prior to participants lifting objects of different sizes. Participants received cTBS over aIPS, the primary motor cortex (control area), or Sham stimulation. We found no evidence that aIPS stimulation affected the size-weight illusion. Effects were, however, found on anticipatory force scaling, where grip force was less tuned to object size during initial lifts. These findings suggest that aIPS is not involved in the perception of object weight but plays a transient role in the sensorimotor predictions related to object size. NEW & NOTEWORTHY Skilled object manipulation requires forming anticipatory motor plans according to the object's properties. Here, we demonstrate the role of anterior intraparietal sulcus (aIPS) in anticipatory grip force scaling to object size, particularly during initial lifting experience. Interestingly, this role was not maintained after continued practice and was not related to perceptual judgments measured with the size-weight illusion.