Putnamcaldwell9501

These data provide strong evidence that Scu can be further developed as a potential new therapeutic drug for preventing or treating reproductive toxicity caused by the exposure of animals to ZEA found in the grains of animal feeds.The effects of potato and traditional staple foods (corn, wheat and rice) on physiology and gut microbiota were investigated by feeding ICR mice for 12 months. Compared with traditional staple foods, potato significantly improved the food and water intake and survival rate, and inhibited the swelling of viscera of mice, accompanied by a decreased white blood cell count and urine bilirubin content. Furthermore, potato significantly increased the relative abundance of Bacteroides and Faecalibacterium, which are short-chain fatty acid producing bacteria and play very important roles in the maintenance of human health. Meanwhile, potato significantly decreased the relative abundance of spoilage bacteria Pseudomonas and Thiobacillus. Analysis of putative metagenomes indicated that the potato diet upregulated the gene abundance of glycan biosynthesis and metabolism, digestive system and immune system. These findings indicated that potato has the potential to be an excellent substitute for traditional staple foods owing to its good physiological function and favorable gut microbiota modulation.The magnetic properties of mononuclear YbIII complexes have been explored by using multiconfigurational CASPT2/RASSI calculations. Such complexes, in particular the case of [Yb(trensal)] complex, have been proposed as molecular qubits due to their spin dynamics properties. We have verified the accuracy of the theoretical approach to study such systems by comparing with experimental magnetic data. Brigatinib cost In order to have a wide overview of the magnetic properties of mononuclear YbIII complexes, we have considered simple charged and neutral models, [Yb(H2O)n]3+ and [Yb(OH)3(H2O)n-3], for many coordination modes. Thus, the results for more than 100 models allow extraction of some conclusions about the best ligand distributions in the coordination sphere to tailor the magnetic properties. Some low coordination, between 3 and 5, complexes that have no experimental magnetic data have been studied computationally to check if they can present high magnetic anisotropy.A donor-acceptor ligand, 3-amino-2-bromo-6-methoxypyridine (ABMeoPy), was introduced to passivate FA0.8Cs0.2PbBr3 nanocrystals (NCs) by a post-processing method. link2 The donor-acceptor interaction can greatly enhance the coordination bond of pyridine-Pb2+, and improve FA0.8Cs0.2PbBr3 NC performance with 95.99% photoluminescence quantum yield (PLQY), 6-month stability in solution, and 26% trap density decrease. In the light of ABMeoPy passivation of FA0.8Cs0.2PbBr3 NCs, the maximum luminance, the maximum current efficiency, and EQE of light-emitting diodes (LEDs) increased 69%, 110%, and 111%, respectively. The strategy of using D-A molecules to passivate perovskite NCs is quite simple and effective, which can be widely promoted in perovskite-based LEDs or solar cells.Pueraria lobata is utilized as a food source in China. The aim of this study is to combine virtual screening and molecular dynamics predictive model to screen out the potential synaptic plasticity-maintaining components from the root of P. lobate and to verify it by employing the amyloid β-injected rats' model. Eighteen compounds were identified by HPLC-MS/MS; puerarin manifested the most potential to form a stable complex with calcium/calmodulin kinase IIα (CaMK IIα), which is the key protein in synaptic plasticity by the in silico study. The further in vivo assay showed that puerarin could elevate the synaptic thickness, density, and length, relieve calcium overload, regulate the expression of CaMK IIα, and other p38MAPK-CREB signaling pathway-related biochemical criteria. The behavioral test also verified the results. Results have confirmed that the root of P. lobate can work anti-AD by maintaining the synaptic plasticity and proved the reliability of using the in silico predictive model to determine active ingredients from the natural product.Calcium phosphates (CaPs) in the form of hydroxyapatite (HA) have been extensively studied in the context of bone regeneration due to their chemical similarity to natural bone mineral. While HA is known to promote osteogenic differentiation, the structural properties of the ceramic have been shown to affect the extent of this effect; several studies have suggested that nanostructured HA can improve the bioactivity. However, the role shape plays in the osteogenic potential is more elusive. Here we studied the effect of HA nanoparticle shape on the ability to induce osteogenesis in human mesenchymal stromal cells (hMSCs) by developing nanoparticle films using needle-, rice- and spherical-shaped HA. We showed that the HA films made from all three shapes of nanoparticles induced increased levels of osteogenic markers (i.e. runt-related transcription factor 2 (RUNX2), bone morphogenetic protein 2 (BMP2), alkaline phosphatase (ALP), osteopontin (OPN), osteocalcin (OCN) on protein and gene level in comparison to hMSCs cultured on cover glass slides. Furthermore, their expression levels and profiles differed significantly as a function of nanoparticle shape. We also showed that nanoparticle films were more efficient in inducing osteogenic gene expression in hMSCs compared to adding nanoparticles to hMSCs in culture media. Finally, we demonstrated that hMSC morphology upon adhesion to the HA nanoparticle films is dependent on nanoparticle shape, with hMSCs exhibiting a more spread morphology on needle-shaped nanoparticle films compared to hMSCs seeded on rice- and spherical-shaped nanoparticle films. Our data suggests that HA nanoparticle films are efficient in inducing hMSC osteogenesis in basic cell culture conditions and that nanoparticle shape plays a vital role in cell adhesion and morphology and extent of induction of osteogenic differentiation.An isolable three-coordinate dialkylsilanone without substantial electronic stabilization reacts with several ethers resulting in the cleavage of the C-O or C-H and C-O bonds in the ethers which have not been observed for the hitherto-known electronically stabilised isolable Si[double bond, length as m-dash]O species. The formation of the Lewis base (DMAP and MTHP) complexes of the dialkylsilanone and the DFT calculations elucidated that the coordination of the ethereal oxygen atom to the Lewis acidic Si atom of the genuine Si[double bond, length as m-dash]O bond is a key interaction for the reaction.Constructing high-performance and cost-effective electrocatalysts for water oxidation, particularly for overall water splitting, is extremely needed, whereas still challenging. Herein, based on an economical and facile one-step surface sulfurization strategy, a three-dimensional nanostructure with uniform Fe-doped Ni3S2 nanoparticle arrays tightly implanted on nickel foam (Fe-doped Ni3S2-NF) has been fabricated for the extremely efficient electrochemical oxygen evolution reaction (OER). Owing to the unique electronic structure modulation between Ni and Fe sites, and high interfacial charge communication during the electrocatalytic process, the optimal Fe-doped Ni3S2-NF electrode shows an excellent OER activity with ultralow overpotentials of 166 and 235 mV at 10 and 100 mA cm-2 in alkaline solution, respectively, remarkably outcompeting the benchmark RuO2/NF and the overwhelming majority of the reported electrocatalysts. Furthermore, for overall water splitting, the Fe-doped Ni3S2-NF electrode as a bifunctional electrocatalyst assembled in a two-electrode device requires merely 1.56 V to gain a current density of 10 mA cm-2. This study presents a universal surface engineering strategy to conveniently and economically remould commercial metal materials into efficient electrocatalysts for various electrochemical reactions.In this work, we report a new type of reactivity of [(BDI*)Ti(Cl)η2-P(SiMe3)-PiPr2] (1) towards ketones (BDI* = 2,6-diisopropylphenyl-β-methyldiketiminate ligand). In the reaction of 1 with acetone, cyclopentanone or cyclohexanone, a ketone moiety is inserted into Ti-Pphosphanyl or Ti-Pphosphido bonds to form complexes with a new C-P-P moiety, providing [(BDI*)Ti(Cl)η2-P(SiMe3)-PiPr2-C(Me)2O] (2a), [(BDI*)Ti(Cl)η2-OC(Me)2P(SiMe3)-PiPr2] (2b), [(BDI*)Ti(Cl)η2-P(SiMe3)-P(iPr)2-C(CH2)4O] (3a), and [(BDI*)Ti(Cl)η2-P(SiMe3)-P(iPr)2-C(CH2)5O] (4a). Starting complex 1 reacts with cyclohexanone, yielding a monocrystalline complex [(ArN[double bond, length as m-dash]C(Me)CHC(Me)[double bond, length as m-dash]NAr)C(CH2)5OTi(Cl)PiPr2-P(SiMe3)C(CH2)5O] (4d) with the insertion of two ketone molecules. Interestingly, we found that monoinserted complexes 2a and 3a may be oxidized via a reaction with AgCl, leading to elimination of the -SiMe3 group and oxidation of the titanium atom. This reaction led us to isolate the Ti(iv) complex [(BDI*)Ti(Cl)η2-P-P(iPr)2-C(CH2)5O] (5) in crystalline form. To identify the kinds of products that may be formed and determine which products are the most energetically favoured ones, we conducted a thermodynamic DFT study of 1 towards acetone, cyclopentanone and cyclohexanone. Structures 2a, 2b, 3a, 3e, 4a, 4d, and 5 were characterized by X-ray crystallography, and complex 5 was also identified by NMR spectroscopy.Platinum-based anticancer drugs constitute the cornerstone of chemotherapy for various cancers. Although cytotoxic agents are considered to have immunosuppressive effects, increasing evidence suggests that some cytotoxic compounds can effectively stimulate the antitumor immune response by inducing a special type of apoptosis called immunogenic cell death (ICD). A platinum(iv) complex (DCP) modified with the derivative of synthetic capsaicin (nonivamide) was designed to elicit ICD. The complex exhibited high cytotoxicity against a panel of human cancer cell lines including pancreas (PANC-1), breast (MCF-7), and liver (HepG2) cancer cells, and osteosarcoma (MG-63) cells. In addition to causing DNA damage, DCP also triggered the translocation of calreticulin (CRT) as well as the release of ATP and HMGB1 protein in PANC-1 cells, thus manifesting an efficient ICD-inducing effect on cancer cells. Furthermore, the DCP-treated PANC-1 cell-conditioned culture medium promoted the release of IFN-γ and TNF-α to induce the immune response of human peripheral blood mononuclear cells, thereby increasing their cytotoxicity to cancer cells. Concurrently, the phagocytosis of PANC-1 cells by macrophages was also augmented by DCP. The results demonstrate that DCP is an effective inducer of ICD and a potential agent for chemoimmunotherapy of cancers.Adipose tissue-derived mesenchymal stem cell (ADSC)-based therapy is attractive for liver diseases, but the long-term therapeutic outcome is still far from satisfaction due to the low hepatic engraftment efficiency of ADSC transplantation. Herein, we propose a strategy based on liver sinusoidal endothelial cell (LSEC)-targeting peptide modification and near infrared (NIR) fluorescent probe labeling for enhancing LSEC-barrier-migration ability and in vivo tracking of ADSCs in a liver injury mouse model. RLTRKRGLK (RK), a LSEC-targeted peptide, and indocyanine green (ICG), a FDA approved infrared fluorescent dye, were simultaneously modified on the ADSC surface via a bioorthogonal click reaction. The equipped ADSCs not only exhibited significant binding ability towards LSEC both in vitro and in vivo, but could also be monitored by NIR imaging in vivo. In particular, the RK-modified ADSCs showed remarkable higher hepatic accumulation as compared to unmodified ADSCs, resulting in better therapeutic outcomes. link3 Therefore, this study provides a simple and convenient method for enhancing the homing of transplanted ADSCs to injured liver accompanying with in vivo cell tracking ability, which may shed light on accelerating the clinical translation of the ADSC-based therapy for liver diseases.