Mejiaconway4082

There are generic fixed-dose combinations (FDCs) of ritonavir-boosted darunavir (DRV/r) available in Argentina. Experiences with these FDCs in dual therapy remain limited in clinical practice. We aimed to describe clinical and virologic outcomes in patients exposed to FDC DRV/r + raltegravir (RAL) 400 mg every 12 h in a real-life setting.

Retrospective analysis of electronic medical records of HIV-infected patients under FDC DRV/r + RAL in an HIV clinic in Argentina (2014-2018). Individuals were classified as "switch group" (SG, undetectable viral load [VL] with any toxicity/comorbidity) and "virologic group· (VG, detectable viremia and infection by multidrug-resistant HIV).

Of 7,380 patients on ART, 116 (1.5%) received FDC DRV/r + RAL, being 58% in SG. Sixty percent received DRV/r 800/100 mg dose (rest, 600/100 mg). The median (IQR) age and CD4+ T-cell count were 52 (42-58) years, and 373 cell/µL (202-642). Ninety-eight percent were ART-experienced with a median of 3 (IQR 2-5) prior treatments. Main reasons for switch (SG) were renal (57%), cardiovascular (54%) and bone (14%) comorbidities. ARS-1620 chemical structure Median exposure to DRV/r + RAL was 18 months. Among patients in SG, 98% and 96% had undetectable VL at 6 and 12 months; in the VG, 89% and 87% had undetectable VL at 6 and 12 months. No patient required suspension due to toxicity/ intolerance.

In this cohort of mostly experienced HIV-infected patients, FDC DRV/r + RAL was effective and safe. Such therapy may be considered an option for patients with comorbid conditions and/or with multidrug-resistant HIV.

In this cohort of mostly experienced HIV-infected patients, FDC DRV/r + RAL was effective and safe. Such therapy may be considered an option for patients with comorbid conditions and/or with multidrug-resistant HIV.The review article examines the methodology for the complex treatment of patients with occlusion anomalies without prior orthodontic treatment, the problems of treating patients with combined jaw deformities, the history of the development and appearance of orthognathic surgery, the prerequisites for the emergence of a two-stage treatment method. Differences between two-step and classic treatment protocols. The authors described the problems associated with the use of the two-stage treatment method, the advantages of the two-stage treatment method in comparison with the classic three-stage approach, examined the goals, objectives and differences of orthodontic treatment, identified the problems associated with the implementation of this treatment method.Translucent zirconia ceramics for fabrication monolithic restorations is a ceramic material of latest generation. The objective of this literature review is discussing the ways to increase the transparency of zirconia, novel technologies of its manufacturing (part 1) and laboratory procedures for fabrication translucent zirconia restorations, factors affecting the transparency, optical and physico-mechanical properties of the material, as well as indications for its use (part 2).The article presents a detailed protocol of cone beam computed tomography (CBCT), which includes not only the classic analysis of dentoalveolar and skeletal disorders, but diagnosis of cranial patterns (craniocervical cephalometric analysis by M. link2 Rocabado, cephalometric diagnosis by Sassouni PLUS), analysis of transverse jaw sizes (Penn analysis) and measuring the volume of the airway for screening of obstructive sleep apnea. The literature review was conducted using the PubMed in the Scopus and Medline electronic databases through April 2020. Combining several methods of interpretation of CBCT in a single protocol will allow doctors to obtain a more complete amount of information to make a complete plan of comprehensive treatment.

To evaluate the status of individual hemodynamic parameters (HR) and respiratory indicators of dentists performing local anesthesia. Material and methods. In the period from April 2019 to December 2019 the determination of heart rate (Heart rate) and blood saturation at 120 doctors aged 25-55 years was performed. The value of blood saturation by non-invasive pulse oximeter technique SpO

measurement range 0-99%; heart rate range 18-300 beats per minute. The limit of 95-98% was considered normal. However, we consider it correct to note the introduction of an error of 0.1% due to the constant wearing of a dentist's tight polymer mask. All subjects were preliminarily determined by Robergs-Landvere formula maximum heart rate (MF)=205.8-(0.685·age).

Maximum HR limits for the groups of subjects were 185.6±3.1 beats per minute in the first group; 178.7±3.1 beats per minute in the second group; 171.5±3.4 beats per minute in the third group. link3 In all groups the tendency to decrease blood saturation in case of pain .1%, on the upper jaw - 96.3-96.6%.The aim. Study the adverse drug reactions (ADR) that occur when using local anesthetics (LA) in patients living in the Republic of Crimea and registered during the period 2010-2018.

The objects of the study were 122 notification forms about LA ADR recorded in the regional base (Register) of spontaneous reports called ARCADe (Adverse Reactions in Crimea, Autonomic Database). In most cases, ADR was associated with the use of amide LA Lidocaine - 69 cases (56.55% of the total number of cases for LA ADR), less often, ADR was caused by combinations containing Articaine (34 cases, 27.87%). Rare cases of ADR were reported for Novocaine/Procaine (9 cases, 7.38%), Bupivacaine (8 cases, 6.56%) and Mepivacaine (2 cases, 1.64%). The main clinical manifestations of reactions were hypersensitivity-like reactions (38 cases), cardiac and vascular disorders (29 cases) and central nervous system disorders (19 cases). Lack of effectiveness of LA occurred in 13 cases (10.66%).

A study of the outcome of ADR revealed a high incidence of life-threatening conditions associated with LA use - 31 cases (25.4%), which indicates the severity of the event and the need to cancel the suspected drug and prescribe additional medications for correction. The need for hospitalization or prolongation of hospitalization was necessary in 7 cases (5.8%), and temporary disability of patients was revealed in 5 cases (4.1%). Of particular interest are 2 cases (1.6%) of the development of a fatal outcome as a result of the suspected anaphylactic shock (1 case) and disorders of the central nervous system (convulsions, development of respiratory failure).

The high frequency and severity of unwanted effects resulted from the use of LA requires healthcare professionals to make rational choices and strictly monitor patient safety.

The high frequency and severity of unwanted effects resulted from the use of LA requires healthcare professionals to make rational choices and strictly monitor patient safety.The measurement of the film thickness of the composite cement Variolink Esthetic («Ivoclar-Vivadent», Liechtenstein) and the microhybrid composite Enamel («Micerium», Italy) was carried out according to ISO 4049 2009 standards with a load force of 5 kg. While reducing the load force to 5 kg, all materials showed an increase in the film thickness; the film thickness of the Variolink Esthetic composite cement was changed from 23 microns (at 15 kg) to 32 microns (at 5 kg), and the film thickness of the microhybrid composite film Enamel was changed from 39 microns (at 15 kg) to 102 microns (at 5 kg). After preheating, the film thickness was changed from 23 microns (at 15 kg) to 44 microns (at 5 kg).The study convincingly showed the presence of negative trends in the provision of medical dental organizations with material supplies. Thus, in 2014-2018 the basic growth rate of financial resources allocate for these purposes was only 15.96%. The corresponding value for the renewal of drugs and dressing materials equaled 12.28%, for reagents and chemicals, glass, chemical glassware - 6.62%, a decrease was revealed in the costs of medical instruments and food. The real amount of expenses for updating inventory in 1 working day for 1 doctor in the profile of dentistry and dental hygienist should correspond to 2067.16 rubles, which is 3.49 times higher than the allocated financial resources. Dentistry is still not included in the priority areas of healthcare in terms of financing. Under such circumstances, medical dental organizations cannot satisfy the growing need of the population for high-quality dental care. New technologies integration in the daily dental practice dictates the need for of new standards formation and a list of expenditure of inventories in the provision of medical and diagnostic assistance in the field of «dentistry».The study showed the presence of negative dynamics in the provision of population with orthopedic dentists and dental technicians, as well as a decrease in the staffing of medical organizations with these specialists. The fact of exceeding the basic rate of loss of dental technicians over the same indicator for dentists-orthopedists by 2 times was established. The possibility of increasing the availability of personnel by combining positions is revealed, since the coefficient of concurrency among dentists-orthopedists and dental technicians is less than the average for the specialty. The trends of decreasing interest of specialists in obtaining qualification categories are noted. According to the survey of 305 specialists, a model of the most probable structural «profile» of a dentist-orthopedist was created and the characteristic features of the learning processes and practical use of knowledge on the main new technologies in orthopedic dentistry were determined. The data obtained in the course of the study indicate that there are limited opportunities to improve the availability and quality of dental orthopedic care and the introduction of new prosthetics technologies.Purpose of work is to determine the objective possibility of achieving the goal of the CHI program-the protection of the constitutional rights of citizens to receive free quality and affordable dental care based on the analysis of the potential of doctors in the field of dentistry. The study used the materials of the state statistical annual reports of the Ministry of health of the Russian Federation, forms No. 30 and No. 14-MED (CHI). The system of balanced indicators adapted by us served as a tool for effective process analysis of the personnel potential of doctors in the field of dentistry. Incorporating factor for achieving a strategic goal for the system CHI the results of analysis of practice-oriented factors of the potential of specialist doctors dentistry meets up 3.88 points, and the objective possibility of implementation of the CHI in the field of dentistry is 77.6 per cent. This indicator allows to measure the degree of success of the CHI system in the present and future and is intended for management as a decision-making tool in the process of personnel management.

Was to compare the efficacy of Ca(OH)

apexification and regenerative endodontic procedure (REP) in immature teeth with pulp necrosis. The pilot study included 12 children aged 89 to 126 months having pulp necrosis in immature incisors. Dental trauma was the etiology for pulp necrosis in all cases and initial X-rays showed periapical translucency lesions (PTL). The patients were randomly divided in 2 groups with either Ca(OH)

apexification (group 1,

=6) or REP (group 2,

=6). The root length and the growth of root wall thickness, as well as root to crown ratio and dentinal wall to root canal space ratio was assessed radiologically in 6, 12 and 24 months. The root length increase was detected in 83% of all cases, but the pattern of root dentine growth in the groups was different. Dentin thickness in REP group was more prominent in the apical third and was observed in 100% of cases while in group 1 dentin thickness increased mainly in the coronal and middle third of the root, dentin thickness increased only in 33% of all cases in the apexification group.