Mclambfry2505
In order to be able to develop surgical training of residents through simulation, we carried out a descriptive study, evaluating the satisfaction of participating residents and the benefit of the workshops offered during the 4 th Junior Master Class, free annual training organized in 2017 in Lille University Hospital. It is dedicated to ob-gyn residents in France, overseas departments and territories.
During two days, plenary sessions and practical workshops on animal models or simulators were organized in laparoscopy, diagnostic and operative hysteroscopy, vaginal surgery and robotic surgery. A questionnaire was given anonymously to each student, collecting on the one hand their surgical curriculum, on the other hand, the evaluations of the theoretical contribution and the quality of the interventions and materials offered during the plenary sessions. The last part was subdivided into a questionnaire specific to each workshop.
The 48 residents who voluntarily followed this training were overwhelmingly satisfied with the quality of the training offered. The practical benefits outweighed the theoretical benefits. These workshops improved their practical skills from 63 % to 84 % depending on the workshops offered. In addition, 100 % of students would recommend this training to other residents and consider it useful for their future practice.
These very satisfactory results encourage us to organize new surgical training. Simulation is the key point for an appropriate surgical learning.
These very satisfactory results encourage us to organize new surgical training. Simulation is the key point for an appropriate surgical learning.
The purpose of this study was to investigate the epidemiological, demographical characteristics and survival outcomes of the patients with ovarian metastases from breast cancer.
Medical records of 24 patients with pathologically confirmed metastases in ovaries treated at two tertiary hospitals between 2000 and 2019 were reviewed retrospectively. Patients' as well as tumor characteristics, and treatment data were collected. Ovarian metastases of breast cancer were documented using a system of analogous to the FIGO classification for ovarian cancer. Survival after primary breast cancer diagnosis and after diagnosis of metastases in ovaries were calculated. Outcomes were compared between the three different procedures bilateral salpingo-oophorectomy, total hysterectomy with bilateral salpingo-oophorectomy, and total hysterectomy with bilateral salpingo-oophorectomy with omentectomy.
The majority of patients had estrogen receptor positive (87 %) and progesterone receptor positive (91 %), 80 % patients were to be done in order to confirm prognostic features and the choice of surgical volume.
Our results showed that more radical surgical treatment of metastases to ovaries has no increase of survival among patients. However, it should be noted that this may be affected by different stage of primary disease. Thus, larger and more standardized studies need to be done in order to confirm prognostic features and the choice of surgical volume.
The rate of caesarean delivery between 22 and 28 weeks of gestation (weeks) has increased for several years. The aim of the study was to describe subsequent pregnancies in women with a history of caesarean delivery between 22 and 28 weeks.
We performed a retrospective, observational, bicentric cohort study in tertiary care maternity units. We included women who had a caesarean delivery between 22 and 28 weeks from December 1, 2014 to December 31, 2017. We then retrospectively collected data on subsequent pregnancies of these patients up to March 2020. We described the subsequent pregnancy rate and the outcomes of these pregnancies.
Among the 186 women who had a caesarean between 22 and 28 weeks, data from 103 of them could be collected, including 47 (45.6%) women who had 64 new pregnancies. Of the 47 first pregnancies after the preterm cesarean, 19 (40.4%) were completed at≥37 weeks. The mode of delivery was a cesarean in 23 cases (79.3%). A trial of labor after cesarean was only considered in 7 cases (24.1%), and 6 women (20.7%) gave birth vaginally.
If pregnancy is desired after a caesarean between 22 and 28 weeks, the pregnancy rate is high without recurrence of prematurity in the majority of cases. Cesarean delivery is the most common mode of delivery. In case of trial of labor after cesarean, the success rate is reasonable.
If pregnancy is desired after a caesarean between 22 and 28 weeks, the pregnancy rate is high without recurrence of prematurity in the majority of cases. Cesarean delivery is the most common mode of delivery. In case of trial of labor after cesarean, the success rate is reasonable.Various stressors including temperature, environmental chemicals, and toxins can have profound impacts on immunity to pathogens. Increased eutrophication near rivers and lakes coupled with climate change are predicted to lead to increased algal blooms. Currently, the effects of cyanobacterial toxins on disease resistance in mammals is a largely unexplored area of research. Recent studies have suggested that freshwater cyanotoxins can elicit immunomodulation through interaction with specific components of innate immunity, thus potentially altering disease susceptibility parameters for fish, wildlife, and human health owing to the conserved nature of the vertebrate immune system. In this study, we investigated the effects of three microcystin congeners (LR, LA, and RR), nodularin-R, and cylindrospermopsin for their ability to directly interact with nine different human Toll-like receptors (TLRs)-key pathogen recognition receptors for innate immunity. learn more Toxin concentrations were verified by LC/MS/MS prior to use. Using an established HEK293-hTLR NF-κB reporter assay, we concluded that none of the tested toxins (29-90 nM final concentration) directly interacted with human TLRs in either an agonistic or antagonistic manner. These results suggest that earlier reports of cyanotoxin-induced NF-κB responses likely occur through different surface receptors to mediate inflammation.
