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Starch hydrogel is a biocompatible and biodegradable material. However, due to its poor mechanical properties and fragility, starch hydrogel has limited applications in the food and medicine industries. In this work, we prepared stretchable, compressible, and self-healing double-network (DN) hydrogels using hydroxypropyl starch (HPS) and sodium alginate (SA). By adjusting the amount of sodium alginate added, the DN hydrogels achieved adjustable mechanical properties. The storage modulus of the DN hydrogels with 1% SA increased by nearly 80 times compared with that of pure HPS hydrogels. When prepared in a water/glycerol binary mixed solvent, the DN hydrogels can maintain their gel properties at -30 ºC. These environmentally friendly and biocompatible hydrogels have broad application prospects in the fields of agriculture, food, and medicine.Phytoglycogen nanoparticles are highly branched polymers of anhydroglucose units (AGUs) produced as soft, compact nanoparticles by sweet corn. By combining results of dialysis, ellipsometry and gravimetric analysis experiments, we constructed a master plot of the osmotic pressure Π -concentration C data for phytoglycogen nanoparticles that spans the complete range ∼ 0% w/w less then C less then ∼ 100 % w/w. Selleck Cinchocaine The distinctive shape of the ΠC curve for phytoglycogen differs significantly from that of dextran, a lightly branched polysaccharide also made up of AGUs but not in the form of particles, especially near concentrations corresponding to contact between the nanoparticles. By calculating the dependence of the osmotic pressure on the volume per particle, we determined the increase in the bulk modulus of the particles with decreasing particle volume due to removal of water from the particles upon compression. This approach allowed us to quantify the strong correlation between the mechanical and hydration properties of phytoglycogen nanoparticles.Herein, we report the preparation of an organic-inorganic hybrid hydrogel architecture using vinyl alginate and UiO-66 MOFs (metal-organic frameworks) modified with acrylic acid (AA) UiO-66AA. UiO-66 MOFs with different crystal sizes (600, 1500, and 2500 nm) were synthesized and the effect on the mechanical and transport properties of the resulting materials, such as water absorption capacity and drug release, were evaluated. HydroMOF showed higher water absorption capacity than the pure hydrogel and enhanced mechanical properties, which depend on crystal size and the amount of UiO-66AA MOF used. The initial release rate of drug (burst release) from hydroMOFs was lower when small-sized crystals or a small amount of large-sized crystals were used; thus these are essential in changing half-life values of release rates. Finally, the cytotoxicity screening successfully showed that hydroMOFs are promising biocompatible compounds proven to have the advantages of minimized burst release and mechanical robustness.Alginate is a natural polysaccharide resource abundant in brown algae and it can be cleaved into alginate oligosaccharides by alginate lyase. Alginate lyases and the bioactive alginate oligosaccharides have been applied in diverse fields such as pharmaceutical therapy and nutraceutical supplementation. Immobilized enzymes greatly facilitate their industrial application owing to their reusability, stability, and tunability. In this study, magnetic Fe3O4 nanoparticles were synthesized and used to immobilize an exolytic alginate lyase AlgL17 that was characterized previously. The immobilized AlgL17 demonstrated enhanced thermal and pH tolerance, extended storage stability, and moderate reusability. The mass spectrum indicated the specific activity of the immobilized AlgL17 to release alginate oligosaccharides (AOS) from alginate polysaccharide. The produced AOS exhibited their antioxidant and antiapoptotic activities in H2O2-stressed human umbilical vein endothelial cells by upregulation of reactive oxygen species scavenging activities and attenuation of the caspase-mediated apoptosis pathway.Separator is a vital component of lithium-ion batteries (LIBs) due to its important roles in the safety and electrochemical performance of the batteries. Herein, we reported a cellulose nanofibrils (CNFs) reinforced pure cellulose paper (CCP) as a LIBs separator fabricated by a facile filtration process. The nanosized CNFs played crucial roles as a tuner to optimize the pore size of the as-prepared CCP, and also as a reinforcer to improve the mechanical strength of the resultant CCP. Results showed that the tensile strength of the CCP with 20 wt.% CNFs was 227 % higher compared to the commercial cellulose separator. In addition, the lithium cobalt oxide/lithium metal battery assembled with CCP separator displayed better cycle performance and working stability (capacity retention ratio of 91 % after 100 cycles) compared to the batteries with cellulose separator (52 %) and polypropylene separator (84 %) owing to the multiple synergies between CCP separator and electrolytes.The aim of this study was to investigate the surface morphological features and in vivo immunomodulatory activities of a hetero polysaccharide fraction (HEP-W) from Hericium erinaceus. SEM and AFM images revealed that HEP-W displayed a flexible random coil conformation, and these flexible winding chains further formed continuous fiber network structure. Meanwhile, Congo red assay and XRD further proved that HEP-W mainly exhibited amorphous structure with non-triple-helical conformation in solution. In vivo immunomodulatory experiments demonstrated that HEP-W possessed protective effects against cyclophosphamide-induced immunosuppression in mice by significantly enhancing immune organ index, splenocyte proliferation, NK cell activity, IL-2 production as well as improving the macrophage phagocytosis. These findings suggest that HEP-W could be explored as a natural and effective immunomodulatory agent.Stimulated by researches in materials chemistry and medicine fields, drug delivery has entered a new stage of development. Drug delivery systems have been extensively studied according to the differences in the drug therapeutic environment such as pH, light, temperature, magnet, redox, enzymes, etc. Cyclodextrin is a smart tool that has been proven to be used in the preparation of drug delivery, and has become a new area of concern in recent years. In this review, we discuss recent research advances in smart stimuli-responsive cyclodextrin-based drug delivery. First, different stimuli-responsive drug delivery systems based on cyclodextrin are introduced and classified. Then, the characteristics of different types of stimuli-responsive drug delivery systems are described, and their applications are emphasized. Finally, current challenges and future development opportunities of smart stimuli-responsive drug delivery systems based on cyclodextrin are discussed.