Vazquezsharp4409

The T2 group showed lower TGF-β levels than that in the T1 group. This finding was in line with the observed decrease in α-SMA expression and the number of collagen.

MSCs treatment ameliorated LF by suppressing TGF-β production, leading to decreased α-SMA expression in a CCL4-induced LF animal model.

MSCs treatment ameliorated LF by suppressing TGF-β production, leading to decreased α-SMA expression in a CCL4-induced LF animal model.

Disorders of thyroid gland are common in general population, and it's the most common affecting the endocrine system after diabetes mellitus. Thyroid function regulates a wide range of metabolic parameters, as well as affects some cardiovascular disease risk factors. Fructosamine is produced by a reaction between albumin (protein) and glucose; it is used to monitor patients with diabetes for short-term glycemic changes. H-FABP is present in the cytoplasm of cardiac myocytes, and delivers fatty acids into these cells. It has been shown to increase in myocardial injury. Lipoprotein LP(a) is consist of a special apolipoprotein called apoprotein (a), and it's recognized as a cardiovascular disease independent risk factor.

To study whether certain metabolic and cardiovascular markers (fructosamine, H-FABP and lipoprotein (a) are changed in hypothyroid patients.

The current study included 280 overt hypothyroid, 272 with subclinical hypothyroidism compared with 270 healthy individuals of matched age and genderd subjects. Also, we conclude that hypothyroidism increase risk of cardiovascular diseases by changing non-traditional marker such as lipoprotein (a), and no effect on H-FABP concentration.

The key considerations for healthy aging are diversity and inequity. Diversity means that there is no typical older person. Policy should be framed to improve the functional ability of all older people, whether they are robust, care dependent or in between.

The aim of this article is to describe negative influence of Corona pandemic (COVID-19) for realization of the WHO project about Healthy Aging global strategy proposed in the targets "Health for all".

Authors used descriptive model for this cross-sectional study based on facts in analyzed scientific literature deposited in on-line databases about healthy aging concept of the prevention and treatment of the people who will come or already came to the "third trimester of the life".

Some 80-year-olds have levels of physical and mental capacity that compare favorably with 30-year-olds. Others of the same age may require extensive care and support for basic activities like dressing and eating. Policy should be framed to improve the functional ability oftion. But in the first risk group are old people who have in average 6 to 7 co-morbidities. WHO recommended some measures to improve prevention and treatment this category of population, but COVID-19 pandemic stopped full realization of Decade of Healthy Aging project.Food insecurity is a key global health challenge that is likely to be exacerbated by climate change. Though climate change is associated with an increased frequency of extreme weather events, little is known about how multiple environmental shocks in close succession interact to impact household health and well-being. In this paper, we assess how earthquake exposure followed by monsoon rainfall anomalies affect food insecurity in Nepal. We link food security data from the 2016 Nepal Demographic and Health Survey to data on shaking intensity during the 2015 Gorkha earthquake and rainfall anomalies during the 2015 monsoon season. We then exploit spatial variation in exposure to the earthquake and monsoon rainfall anomalies to isolate their independent and compound effects. We find that earthquake exposure alone was not associated with an increased likelihood of food insecurity, likely due in part to effective food aid distribution. However, the effects of rainfall anomalies differed by severity of earthquake exposure. Among households minimally impacted by the earthquake, low rainfall was associated with increased food insecurity, likely due to lower agricultural productivity in drought conditions. Among households that experienced at least moderate shaking, greater rainfall was positively associated with food insecurity, particularly in steep, mountainous areas. In these locations, rainfall events disproportionately increased landslides, which damaged roads, disrupted distribution of food aid, and destroyed agricultural land and assets. Additional research on the social impacts of compound environmental shocks is needed to inform adaptation strategies that work to improve well-being in the face of climate change.To advance our understanding of speech motor control, it is essential to image and assess dynamic functional patterns of internal structures caused by the complex muscle anatomy inside the human tongue. Speech pathologists are investigating into new tools that help assessment of internal tongue muscle's cooperative mechanics on top of their anatomical differences. Previous studies using dynamic magnetic resonance imaging (MRI) of the tongue revealed that tongue muscles tend to function in different groups during speech, especially the floor-of-the-mouth (FOM) muscles. In this work, we developed a method that analyzed the unique functional pattern of the FOM muscles in speech. First, four-dimensional motion fields of the whole tongue were computed using tagged MRI. Meanwhile, a statistical atlas of the tongue was constructed to form a common space for subject comparison, while a manually delineated mask of internal tongue muscles was used to separate individual muscle's motion. Then we computed four-dimensional motion correlation between each muscle and the FOM muscle group. Finally, dynamic correlation of different muscle groups was compared and evaluated. We used data from a study group of nineteen subjects including both healthy controls and oral cancer patients. Results revealed that most internal tongue muscles coordinated in a similar pattern in speech while the FOM muscles followed a unique pattern that helped supporting the tongue body and pivoting its rotation. The proposed method can help provide further interpretation of clinical observations and speech motor control from an imaging point of view.Over the past several years, a number of strategies for the functionalization of dicarba-closo-dodecaboranes (carboranes) have emerged. Despite these developments, B - N bond formation on the carborane scaffold remains a challenge due to the propensity of strong nucleophiles to partially deboronate the parent closo-carborane cluster into the corresponding nido form. Here we show that azide, sulfonamide, cyanate, and phosphoramidate nucleophiles can be straightforwardly cross-coupled onto the B(9) vertices of the o- and m-carborane core from readily accessible precursors without significant deboronation by-products, laying the groundwork for further study into the utility and properties of these new B-aminated carborane species. We further showcase select reactivity of the installed functional groups highlighting some unique features stemming from the combination of the electron-donating B(9) position and the large steric profile of the B-connected carborane substituent.The current research sought to shed light on the behavioral science that underlies the spread of SARS-CoV-2. We tested the extraversion hypothesis, which suggests that the sociability facet of extraversion may predispose people to becoming infected with the coronavirus via greater human-to-human contact. selleck chemicals llc Since extraverts seek out social opportunities and seem less likely to follow containment measures related to social distancing, we hypothesized that people who have previously become infected would exhibit greater extraversion than would those who have not contracted the virus. We measured overall extraversion and three of its facets-sociability, assertiveness, and energy levels-as well as political orientation. We collected data from 217 adults, aged 40 and older, from the US and the UK, of whom 53 had had the virus at some point prior to the study, and 164 had not. Participants who had had COVID-19 were more dispositionally sociable and were also more conservative-leaning compared to participants who had never had COVID-19. Implications regarding the behavioral science underlying the current pandemic are discussed.Economic policy evaluations require social welfare functions for variable-size populations. Two important candidates are critical-level generalized utilitarianism (CLGU) and rank-discounted critical-level generalized utilitarianism, which was recently characterized by Asheim and Zuber (2014) (AZ). AZ introduce a novel axiom, existence of egalitarian equivalence (EEE). First, we show that, under some uncontroversial criteria for a plausible social welfare relation, EEE suffices to rule out the Repugnant Conclusion of population ethics (without AZ's other novel axioms). Second, we provide a new characterization of CLGU AZ's set of axioms is equivalent to CLGU when EEE is replaced by the axiom same-number independence.Vowel-intrinsic fundamental frequency (IF0), the phenomenon that high vowels tend to have a higher fundamental frequency (f0) than low vowels, has been studied for over a century, but its causal mechanism is still controversial. The most commonly accepted "tongue-pull" hypothesis successfully explains the IF0 difference between high and low vowels but fails to account for gradient IF0 differences among low vowels. Moreover, previous studies that investigated the articulatory correlates of IF0 showed inconsistent results and did not appropriately distinguish between the tongue and the jaw. The current study used articulatory and acoustic data from two large corpora of American English (44 speakers in total) to examine the separate contributions of tongue and jaw height on IF0. Using data subsetting and stepwise linear regression, the results showed that both the jaw and tongue heights were positively correlated with vowel f0, but the contribution of the jaw to IF0 was greater than that of the tongue. These results support a dual mechanism hypothesis in which the tongue-pull mechanism contributes to raising f0 in non-low vowels while a secondary "jaw-push" mechanism plays a more important role in lowering f0 for non-high vowels.Constitutive modeling is a cornerstone for stress analysis of mechanical behaviors of biological soft tissues. Recently, it has been shown that machine learning (ML) techniques, trained by supervised learning, are powerful in building a direct linkage between input and output, which can be the strain and stress relation in constitutive modeling. In this study, we developed a novel generic physics-informed neural network material (NNMat) model which employs a hierarchical learning strategy by following the steps (1) establishing constitutive laws to describe general characteristic behaviors of a class of materials; (2) determining constitutive parameters for an individual subject. A novel neural network structure was proposed which has two sets of parameters (1) a class parameter set for characterizing the general elastic properties; and (2) a subject parameter set (three parameters) for describing individual material response. The trained NNMat model may be directly adopted for a different subject without re-training the class parameters, and only the subject parameters are considered as constitutive parameters.