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Thioredoxin-like protein-1 (TXNL1; also known as thioredoxin-related 32 kDa protein, TRP32) is a thioredoxin involved in the regulation of oxidative stress, which protects cells from damage through redox balance. Studies have shown that TXNL1 has a variety of functions, including cell signal transduction, cell cycle regulation, protein synthesis, modification and degradation, vesicle transport, transcriptional regulation, cell apoptosis, virus replication and oxidative stress regulation, etc., and plays an important role in the occurrence and development of human diseases. Therefore, TXNL1 has a strong correlation with the treatment of cancer and oxidative stress diseases. In this paper, the basic structure, function and potential application value of TXNL1 in diseases are reviewed, so as to open up new targets for the treatment of cancer and oxidative stress-related diseases.

This study aimed to investigate fundus and optical coherence tomography angiography (angio-OCT) manifestations in carotid cavernous fistula (CCF) patients.

Nine eyes of 7 CCF patients diagnosed with digital subtraction angiography (DSA) were included in this study. Best-corrected visual acuity (BCVA), intraocular pressure (IOP), slit lamp, fundus, spectral-domain optical coherence tomography (SD-OCT), and optical coherence tomography angiography (angio-OCT) examination in the CCF patients and 10 normal controls were conducted. Subfoveal choroidal thickness (SFCT) and macular vascular density (VD) were measured and compared with the control group. SFCT and VD were also compared before and after embolization therapy.

Two male and 5 female CCF patients were included. The average age was 59.7 ±10.0 (years). Embolization therapy was conducted in 3 patients. Fundus manifestations included disc oedema and exudation, retinal venular dilation, and retinal haemorrhage. B-scan OCT examination revealed retinal and iological examination of CCF patients.

Since the pandemic, the daily activities of many people occur at home. People connect to the Internet for work, school, shopping, entertainment, and doctor visits, including psychiatrists. Concurrently, cybercrime has surged worldwide. This narrative review examines the changing use of technology, societal impacts of the pandemic, how cybercrime is evolving, individual vulnerabilities to cybercrime, and special concerns for those with mental illness.

Human factors are a central component of cybersecurity as individual behaviors, personality traits, online activities, and attitudes to technology impact vulnerability. Mental illness may increase vulnerability to cybercrime. The risks of cybercrime should be recognized as victims experience long-term psychological and financial consequences. Patients with mental illness may not be aware of the dangers of cybercrime, of risky online behaviors, or the measures to mitigate risk. Technology provides powerful tools for psychiatry but technology must be used with otential aftermath of cybercrime on mental health, and the increased patient risk since the pandemic, including from online mental health services. As a first step to increase patient awareness of cybercrime, psychiatrists should provide a recommended list of trusted sources that educate consumers on cybersecurity.

To describe the evolution of practice patterns for pediatric pyeloplasty and determine how these changes have impacted length of stay (LOS), reoperation rates and return emergency department (ER) visits.

We reviewed our pyeloplasty database from 2008 to 2020 at a quaternary pediatric referral center and we included children 0-18years undergoing pyeloplasty. DRB18 mouse Variables captured included age, sex, baseline and follow-up anteroposterior diameter (APD) and differential renal function (DRF). We also collected data on the use of drains, catheters and/or stents, nausea and vomiting prophylaxis, opioids, regional anesthesia, and non-opioid analgesia. Outcomes were LOS, reoperation rates and ER visits.

A total of 554 patients (565 kidneys) were included. Reoperation rate was 7%, redo rate 4% and ER visits 17%. There was a trend towards less opioids, indwelling catheters and internal stents and increasing non-opioid analgesia, externalized stents, and regional anesthesia during the study period. Same-day dischargein higher complication rates. These data support the development of a pediatric pyeloplasty ERAS protocol to maximize quicker recovery and foster SDD as a goal.

The aims of the present study were to determine during childhood and adolescence (i) the effect of sex on non-oxidative energy production, quantified by the accumulated oxygen deficit (AOD), and (ii) the influence of AOD on high-intensity performance.

Thirty-nine boys and 35 girls aged 10-17years performed a 60s all-out test on a rowing ergometer to determine AOD and mean power output (MPO). Multiplicative allometric modelling was used to assess the concurrent effects of lean body mass (LBM) and age on AOD.

AOD significantly increased with age in both sexes (p < 0.001) with boys exhibiting significantly higher AOD than girls from the age of 14years (10-11.9yr 1.9 vs 1.9L, 12-13.9yr 2.4 vs 2.7L, 14-15.9yr 2.8 vs 4.6L and 16-17.9yr 2.9 vs 5.2L, in girls and boys respectively, p < 0.001). However, a sex difference was no longer significant when AOD was analysed using an allometric model including age and LBM (p = 0.885). Finally, significant correlations were found between AOD and MPO in boys and girls but with lower evidence in girls (r

 = 0.41 vs. 0.89).

Non-oxidative energy production increased more extensively in boys than girls from the age of 14years. Age and LBM accounted for the sexual differentiation of AOD during childhood and adolescence. In addition, AOD was found to be a determinant factor of high-intensity performance, more particularly in boys.

Non-oxidative energy production increased more extensively in boys than girls from the age of 14 years. Age and LBM accounted for the sexual differentiation of AOD during childhood and adolescence. In addition, AOD was found to be a determinant factor of high-intensity performance, more particularly in boys.In this work, an attempt has been made to classify emotional states using electrodermal activity (EDA) signals and multiscale convolutional neural networks. For this, EDA signals are considered from a publicly available "A Dataset for Emotion Analysis using Physiological Signals" (DEAP) database. These signals are decomposed into multiple-scales using the coarse-grained method. The multiscale signals are applied to the Multiscale Convolutional Neural Network (MSCNN) to automatically learn robust features directly from the raw signals. Experiments are performed with the MSCNN approach to evaluate the hypothesis (i) improved classification with electrodermal activity signals, and (ii) multiscale learning captures robust complementary features at a different scale. Results show that the proposed approach is able to differentiate various emotional states. The proposed approach yields a classification accuracy of 69.33% and 71.43% for valence and arousal states, respectively. It is observed that the number of layers and the signal length are the determinants for the classifier performance. The performance of the proposed approach outperforms the single-layer convolutional neural network. The MSCNN approach provides end-to-end learning and classification of emotional states without additional signal processing. Thus, it appears that the proposed method could be a useful tool to assess the difference in emotional states for automated decision making.Yersinia pseudotuberculosis is an enteric bacterium causing yersiniosis in humans. The existing Yersinia pseudotuberculosis detection methods are time-consuming, requiring a sample pretreatment step, and are unable to discriminate live/dead cells. The current work reports a phage-based electrochemical biosensor for rapid and specific detection of Yersinia pseudotuberculosis. The conductive poly(indole-5-carboxylic acid), reduced graphene oxide, and gold nanoparticles are applied for surface modification of the electrode. They possess ultra-high redox stability and retain 97.7% of current response after performing 50 consecutive cycles of cyclic voltammetry.The specific bacteriophages vB_YepM_ZN18 we isolated from hospital sewage water were immobilized on modified electrodes by Au-NH2 bond between gold nanoparticles and phages. The biosensor fabricated with nanomaterials and phages were utilized to detect Yersinia pseudotuberculosis successfully with detection range of 5.30 × 102 to 1.05 × 107 CFU mL-1, detection limit of 3 CFU mL-1, and assay time of 35 min. Moreover, the biosensor can specifically detect live Yersinia pseudotuberculosis without responding to phage-non-host bacteria and dead Yersinia pseudotuberculosis cells. These results suggest that the proposed biosensor is a promising tool for the rapid and selective detection of Yersinia pseudotuberculosis in food, water, and clinical samples.

The number of patients suffering from human papillomavirus (HPV)-associated oropharyngeal cancer has increased in recent decades. To date, the role of medical therapy in patients with squamous cell carcinoma of the head and neck region has only been established in the refractory or metastatic setting (r/mHNSCC).

What are the current treatment options for patients with r/mHNSCC or r/moropharyngeal cancer?

A literature search was conducted on systemic treatment of oropharyngeal cancer and r/mHNSCC.

There is currently no standard treatment for patients with oropharyngeal cancer in refractory or metastatic stages. Since 2017, immunotherapy with checkpoint inhibitors has become increasingly important in the treatment of r/mHNSCC patients. First-line therapy was recently adapted based on the results of the KEYNOTE-48 (KN048) study. For selected patients with r/mHNSCC, there now exists a chemotherapy-free treatment option. Use of immunotherapy also in earlier stages of HNSCC can be expected in the near future.

Medical therapy of r/mHNSCC patients is in a period of great change. Treatment is increasingly based on combination therapy with checkpoint inhibitors.

Medical therapy of r/m HNSCC patients is in a period of great change. Treatment is increasingly based on combination therapy with checkpoint inhibitors.

X-linked hypophosphatemia (XLH) is a rare inherited cause of hypophosphatemic rickets and osteomalacia. It is caused by mutations in the phosphate-regulating endopeptidase homolog, X-linked (PHEX). This results in increased plasma fibroblast growth factor-23 (FGF23), which leads to loss of renal sodium-phosphate co-transporter expression leading to chronic renal phosphate excretion. It also leads to low serum 1,25-dihydroxyvitamin D (1,25(OH)

D), resulting in impaired intestinal phosphate absorption. Chronic hypophosphatemia in XLH leads to impaired endochondral mineralization of the growth plates of long bones with bony deformities. XLH in children and adolescents also causes impaired growth, myopathy, bone pain, and dental abscesses. XLH is the most frequent inherited cause of phosphopenic rickets/osteomalacia. Hypophosphatemia is also found in calcipenic rickets/osteomalacia as a result of secondary hyperparathyroidism. Thus, chronic hypophosphatemia is a common etiologic factor in all types of rickets.