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05) in saliva of breast cancer patients than in control and benign patients. This salivary ATR-FTIR spectral area was prevalidated as a potential diagnostic biomarker of BC. This spectral biomarker was able to discriminate human BC from controls with sensitivity and specificity of 90% and 80%, respectively. Besides, it was able to differentiate BC from benign disease with sensitivity and specificity of 90% and 70%, respectively. Briefly, for the first time, saliva analysis by ATR-FTIR spectroscopy has demonstrated the potential use of salivary spectral biomarkers (1041 cm-1 and 1433-1302.9 cm-1) as a novel alternative for noninvasive BC diagnosis, which could be used for screening purposes. Copyright © 2020 Izabella C. C. Ferreira et al.Transcription factor sex-determining region Y-box 2 (SOX2) involves in the maintenance of cancer stem cells. However, the role of SOX2 in colorectal cancer (CRC) remains unclear. This study was conducted to investigate the effect of SOX2 on CRC. Studies were searched using electronic databases. The combined odds ratios (ORs) or hazard ratios (HRs multivariate Cox survival analysis) with their 95% confidence intervals (CIs) were calculated. The Cancer Genome Atlas (TCGA) and GEO datasets were further applied to validate the survival effect. The functional analysis of SOX2 was investigated. In this work, 13 studies including 2337 patients were identified, and validation data were enrolled from TCGA and GEO datasets. SOX2 expression was not significantly related to age, gender, microsatellite instability (MSI) status, clinical stage, histological grade, tumor size, pT-stage, lymph node metastasis, distal metastasis, and cancer-specific survival (CSS) but was correlated with worse overall survival (OS n = 536 patients) (P less then 0.05). Furthermore, TCGA data demonstrated similar results, with no significant correlation between SOX2 and pathological characteristics. Further validation data (OS n = 1408 and disease-free survival (DFS) n = 1367) showed that SOX2 expression was correlated with worse OS (HR = 1.35, 95% CI 1.11-1.65, P=0.004) and DFS (HR = 1.30, 95% CI 1.04-1.62, P=0.02). The functional analyses showed that SOX2 involved in cell-cell junction, focal adhesion, extracellular matrix- (ECM-) receptor interaction, and MAP kinase activity. Our findings suggest that SOX2 expression may be correlated with the worse prognosis of CRC. Copyright © 2020 Kun Song et al.Objective In this study, we aimed to investigate the associations of three single-nucleotide polymorphisms (SNPs) on TITF1/TITF2 (rs944289, rs965513, and rs1443434) with susceptibility to papillary thyroid carcinoma (PTC) and with nodular goiter (NG) in northern Chinese Han populations. Methods We performed a case-control study comprising 861 PTC patients, 562 NG patients, and 896 normal controls (NCs). One TITF1 SNP (rs944289) and two TITF2 SNPs (rs965513 and rs1443434) were genotyped. Departures from Hardy-Weinberg equilibrium (HWE) in the control group were evaluated using chi-square test. Associations of the SNPs with PTC and with NG were assessed by unconditional logistic regression using the online SNPStats program. Bonferroni correction was performed for multiple tests in genotype analyses. Data analysis was performed by SPSS24.0 unless otherwise specified. Results For rs944289, T allele was associated with increased risks for both PTC (OR = 1.23, 95% CI 1.08-1.41, P=0.002) and NG (OR = 1.28, 95% CI 1.10-1.50, P=0.002) and NG (OR = 1.28, 95% CI 1.10-1.50, P=0.002) and NG (OR = 1.28, 95% CI 1.10-1.50, P=0.002) and NG (OR = 1.28, 95% CI 1.10-1.50, P=0.002) and NG (OR = 1.28, 95% CI 1.10-1.50, P=0.002) and NG (OR = 1.28, 95% CI 1.10-1.50, P=0.002) and NG (OR = 1.28, 95% CI 1.10-1.50, P=0.002) and NG (OR = 1.28, 95% CI 1.10-1.50. Conclusions There are associations of rs944289 and rs1443434 polymorphisms with PTC risk and association of rs944289 polymorphism with NG risk. Haplotypes T-G-G and T-G-T are risk haplotypes of PTC and NG, respectively. Copyright © 2020 Xin Zhang et al.Aim To reveal the role of bacterial translocation (BT) and autophagy in severe acute pancreatitis-induced acute lung injury (SAP-ALI). Methods Rats were separated into a control (sham-operation) group (n = 10) and a SAP group (n = 10) and a SAP group (. Results Levels of TNF-α, IL-6, lipase, and amylase in the SAP group were significantly higher than those in the control group (P less then 0.01). Histopathological score and W/D ratio of the lung in the SAP-BT(+) group were significantly higher than that in the SAP-BT(-) group (P less then 0.01). Histopathological score and W/D ratio of the lung in the SAP-BT(+) group were significantly higher than that in the SAP-BT(-) group (P less then 0.01). Histopathological score and W/D ratio of the lung in the SAP-BT(+) group were significantly higher than that in the SAP-BT(-) group (P less then 0.01). check details Histopathological score and W/D ratio of the lung in the SAP-BT(+) group were significantly higher than that in the SAP-BT(-) group (P less then 0.01). Histopathological score and W/D ratio of the lung in the SAP-BT(+) group were significantly higher than that in the SAP-BT(-) group (P less then 0.01). Histopathological score and W/D ratio of the lung in the SAP-BT(+) group were significantly higher than that in the SAP-BT(-) group (. Conclusions BT can aggravate SAP-ALI with the increasing oxidative stress level, which may be related to the decrease of autophagy level. Copyright © 2020 Hanlin Wang et al.Objectives To investigate whether Helicobacter pylori (H. pylori) infection increases the risk of colorectal adenomatous polyp (CAP) in the context of age and gender. Methods A total of 563 study subjects (male/female, 368/195) from Beijing, China, with higher nursing level who underwent colonoscopy were retrospectively collected. H. pylori and CAP were detected by carbon-13 urea breath test and colorectal colonoscopy. The correlations between the number, size, distribution, and pathological grade of CAP and H. pylori infection were analyzed. The population was further stratified by age and gender in order to examine the risk of H. link2 pylori and CAP in the context of these variables. The influence of H. pylori on the risk of CAP was assessed by logistic regression model. Results 315 participants were diagnosed with CAP, and 207 participants were classified as healthy controls. The prevalence of H. pylori in the CAP group was significantly higher than that in the healthy control group (119/315, 37.8% versus 44/207, 21.3%) (p 50 years old (87/250; 34.8% versus 32/65; 49.2%) (. Conclusions H. pylori is a major risk factor for CAP. Further studies are needed to assess the effects of H. pylori treatment or persistent infection on the occurrence or recurrence of CAP. link3 Copyright © 2020 Xia-Xia Zhao et al.The robot simultaneous localization and mapping (SLAM) is a very important and useful technology in the robotic field. However, the environmental map constructed by the traditional visual SLAM method contains little semantic information, which cannot satisfy the needs of complex applications. The semantic map can deal with this problem efficiently, which has become a research hot spot. This paper proposed an improved deep residual network- (ResNet-) based semantic SLAM method for monocular vision robots. In the proposed approach, an improved image matching algorithm based on feature points is presented, to enhance the anti-interference ability of the algorithm. Then, the robust feature point extraction method is adopted in the front-end module of the SLAM system, which can effectively reduce the probability of camera tracking loss. In addition, the improved key frame insertion method is introduced in the visual SLAM system to enhance the stability of the system during the turning and moving of the robot. Furthermore, an improved ResNet model is proposed to extract the semantic information of the environment to complete the construction of the semantic map of the environment. Finally, various experiments are conducted and the results show that the proposed method is effective. Copyright © 2020 Jianjun Ni et al.in English, Portuguese, Objetivo Descrever as tendências temporais dos indicadores da hanseníase na população idosa do Brasil de 2001 a 2018. Métodos O presente estudo ecológico de séries temporais analisou os novos casos de hanseníase em idosos (60 anos ou mais) notificados ao Sistema de Informação de Agravos de Notificação (SINAN). Foi usada regressão linear generalizada de Prais-Winsten para estimar as variações temporais. Resultados De 2001 a 2018, houve 687 317 novos casos de hanseníase no Brasil, dos quais 129 214 (18,8%) foram em idosos. As taxas de detecção em idosos e os casos novos com grau 2 de incapacidade apresentaram tendência decrescente, com variação percentual anual de –4,6% (IC95% –5,1 a –4,0) e –3,9% (IC95% –4,6 a –3,2), respectivamente. Por sua vez, a tendência foi crescente para novos casos e novos casos multibacilares, com variação percentual anual de 2,9% (IC95% 2,6 a 3,3) e 1,4% (IC95% 1,0 a 1,7), respectivamente. As taxas de detecção de novos casos de hanseníase em idosos no Brasil estão diminuindo, mas a proporção de novos casos e de casos multibacilares tende a aumentar. Conclusões Os novos casos estão se deslocando para os grupos etários mais velhos, possivelmente devido a fatores relacionados com a transição demográfica e a imunossenescência. A redução insuficiente na incapacidade de grau 2 indica que o risco de incapacidade física permanece elevado. Nessa faixa etária, é necessário um melhor monitoramento dos contatos e uma ação mais efetiva.Based on molecular phylogenetic and morphological evidence, the new genus Linosporopsis (Xylariales) is established for several species previously classified within Linospora (Diaporthales). Fresh collections of Linospora ischnotheca from dead overwintered leaves of Fagus sylvatica and of L. ochracea from dead overwintered leaves of Malus domestica, Pyrus communis, and Sorbus intermedia were isolated in pure culture, and molecular phylogenetic analyses of a multi-locus matrix of partial nuITS-LSU rDNA, RPB2 and TUB2 sequences as well as morphological investigations revealed that both species are unrelated to the diaporthalean genus Linospora, but belong to Xylariaceae sensu stricto. The new combinations Linosporopsis ischnotheca and L. ochracea are proposed, the species are described and illustrated, and their basionyms lecto- and epitypified. Linospora faginea is synonymized with L. ischnotheca. Based on similar morphology and ecology, Linospora carpini and Linospora magnagutiana from dead leaves of Carpinus betulus and Sorbus torminalis, respectively, are also combined in Linosporopsis. The four accepted species of Linosporopsis are illustrated, a key to species is provided and their ecology is discussed. © The Author(s) 2020.Background Carcinoma of unknown primary represents a therapeutic challenge in oncological practice. Evidence lacks to support particular chemotherapy selection and empirical therapies are commonly extrapolated from data on patients where primary tumor site is known. Gemcitabine, Oxaliplatin, Leucovorin and 5-Fluorouracil was previously developed to treat pancreatic cancer. These agents have also demonstrated activities in other gastrointestinal malignancies. Considering promising anti-tumor effects of GOLF, we performed a retrospective study to investigate anti-tumor activity and safety of a simplified Gemcitabine, Oxaliplatin, Leucovorin and 5-Fluorouracil in patients with Carcinoma of unknown primary in whom immunohistostaining was suggestive of either upper gastrointestinal cancers or pancreatobiliary cancers. Methods This retrospective study included 18 patients recorded to have a diagnosis of Carcinoma of unknown primary between Aug 2010-Dec 2015, who received biweekly G 1000 mg/m2, O 85 mg/m2, L 200 mg/m2 and F 2400 mg/m2 over 46-h on day 1 with pegfilgrastim on day 3 every 14 days.