Malmbergrohde5839

The study found that the use of CS extracts of the drug show in the experiment in vivo antagonistic effect, in the comparison with the antibiotic, on microorganisms, but did not inhibit the representatives of normal gut microbiota. Thus, certain efficacy of CS for the correction of dysbiotic disorders has been revealed, which may be promising for further study of the use of CS extracts in the complex treatment of colitis.The aim of the research was to investigate the effect of aminoguanidine on the content of autoantibodies in the serum, nitric oxide synthesis (NO), glial fibrillary acidic protein (GFAP) content and indicators of free radical oxidation in the cerebral hemispheres of BALB/c mice with antiphospholipid syndrome (APS) on the 18th day of pregnancy. An increase in the content of autoantibodies to brain proteins (120 kDa, 150 kDa, and >170 kDa) was detected in the serum of BALB/c mice with APS on the 18th day of pregnancy. An increase in the content of GFAP (total), GFAP (49-37 kDa), NO2¯, NO3¯ and prooxidant-antioxidant system imbalance in the cerebral hemispheres of pregnant mice with APS was established. With administration of aminoguanidine into the pregnant mice with APS, a decrease in the content of autoantibodies to brain proteins (120 kDa and 150 kDa) in serum was proved. With the introduction of aminoguanidine, a selective inhibitor of inducible NO synthase on the 18th day of pregnancy the increase in GFAP (49-37 kDa) in the cerebral hemispheres of APS mice was established, and the GFAP (total), NO2¯ and NO3¯ content did not change significantly, relative to the indicators of pregnant animals with APS. With introduction of aminoguanidine in cases of APS on the 18th day of pregnancy lesser manifestations of oxidative stress in the cerebral hemispheres, a decrease in the activity of lipid peroxidation processes, an increase in the activity and content of the antioxidant system components was evidenced. Thus, aminoguanidine has a neuroprotective effect in obstetric antiphospholipid syndrome in the BALB/c mice.Depression is one the most common form of mental diseases. Due to epidemiological studies, it is common in different age groups including young people. Depression pathogenesis from the point of system perspective view consists of morphofunctional and pathopsychological components. The former can be divided into neuroanatomical, neurophysiological, neurochemical parts. Laboratory animals as experimental models are an invaluable tool for investigating pathogenesis of depressive disorders and creating potential treatments. Aim of study - to elucidate behavioral differences in Danio rerio exposed to selective serotonin reuptake inhibitors (SSRI). In our study Danio rerio was used as an experimental model of depression. In fish forming schools during separation in pairs, anxious and aggressive behavior towards each other was manifested. It contributes to formation of dominant-subordinate relationships. Before administration of fluoxetine and sertraline in all the groups studied, the lower level of fish swimming was observed. They were hyperactive. Aggressive behavior towards each other was not observed. Mitomycin C mouse On the third day of the experiment behavior of the fish in groups with fluoxetine and sertraline was different. In group with sertraline 25% of fishes come up to average level. In group with fluoxetine fishes remained at the bottom of the aquarium. On the fifth day of the experiment in the group with sertraline 25% of fishes had an abnormal craniocaudal position of the body in space.One of the most common complication of diabetes mellitus (DM) is diabetic cardiomyopathy, which is associated with the development of inflammation, fibrosis and the induction of apoptosis. Hydrogen sulfide (H2S) has recently been shown to play an important role in the regulation of cardiac and vascular function. The role of the H2S system in the mechanisms of diabetic heart development remains uncertain. The aim of this work was to evaluate the effect of modulators of H2S system on the level of DNA fragmentation and H2S concentration in heart of rats with experimental diabetes mellitus. The experiment was performed on 40 white laboratory male rats (180-250 g), randomly divided into 4 groups (n=10) healthy (control), diabetes mellitus induced by streptozotocin (STZ), diabetes mellitus + propargylglycine, inhibitor of cystathionine gamma lyase (STZ + PPG), diabetes mellitus + NaHS, exogenous H2S donor (STZ + NaHS). The experimental DM was induced by a single intraperitoneal injection of streptozotocin (40 mg/kgon for the prevention of the development of cardiovascular complications of diabetes.Psoriasis is a systemic immune-mediate disease associated with increased risk of comorbidities. Psychopathological disorders in patients with psoriasis remain poorly understood, despite the large number of publications. The aim of the study is to discuss psychological and mental disorders in patients with psoriasis and identify possible common mechanisms of pathogenesis based on the analysis of data of relevant scientific literature. The development of psoriasis is associated with the expressed negative emotions in more than half of patients. Most psoriasis patients indicate a negative impact of the disease on quality of life. The main comorbidity of psychological and psychiatric psoriasis include alexithymia, anxiety and depression including sexual and sleep disorders. Mental and psychological disorders in patients may be primary, but more often secondary to psoriasis. Studies show the involvement of inflammatory mediators (proinflammatory cytokines) and melatonin in the pathogenesis of both psoriasis and psychopathological disorders, with immune inflammation being a key link. Assessment of psychological and psychiatric status will allow timely identification of comorbid pathology and will optimize the therapeutic tactics of treating patients with psoriasis.The article elucidates the findings of a theoretical and empirical study of the decisiveness features of the individuals who differ in their emotional disposition. The study is of great scientific importance in view of the social and cultural transformations in modern society, which demand an individual's ability to make choices in the utterly difficult situations of social instability. The scientific approach to the development of this issue implies the search for psychological resources, indicators of decisiveness, and the study of its individual-typological features of people with different emotional disposition, and subsequently, those with disorders in the emotional sphere. The study approaches decisiveness as a complex, integral personality trait that ensures successful decision-making. The decisiveness pattern embraces several blocks of indicators a block of setting indicators, a block of psychophysiological indicators, a block of cognition indicators, a block of the personality-related components of decisiveness.