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Childhood obesity is a significant and growing problem worldwide. Recent evidence suggests Follistatin-like 1 (FSTL1) and family with sequence similarity to 19 member A5 (FAM19A5) to be novel adipokines. However, very few studies have examined the plasma levels of FSTL1 and FAM19A5 in children. Therefore, this cross-sectional study evaluated the association between serum FSTL1 and FAM19A5 levels and obesity in children and investigated the relationship between FSTL1 and FAM19A5 and glucose metabolism or endothelial injury.
Fifty-five obese children and 48 healthy controls were recruited. Plasma FSTL1 and FAM19A5 levels were detected using ELISA. In addition, the association between the clinical data and anthropometric parameters was analyzed.
Serum FAM19A5 levels were significantly decreased in the obese children, at 189.39 ± 19.10 pg/mL, compared with those without obesity, at 211.08 ± 38.09 pg/mL. Serum concentrations of FSTL1 were also significantly lower in the obese children, at 0.64 (0.37-0.64) ng/mL, compared with those without obesity, at 1.35 (1.05-2.12) ng/mL. CI-1011 In addition, FAM19A5 (OR = 0.943; p = 0.003) was a predictor of insulin resistance in obese children compared with healthy controls. Lastly, serum FAM19A5 and FSTL1 played mediating roles in insulin resistance in children.
The serum levels of FAM19A5 and FSTL1 were decreased in obese children; therefore, FAM19A5 and FSTL1 likely play important roles in glucose metabolism in obese children.
The serum levels of FAM19A5 and FSTL1 were decreased in obese children; therefore, FAM19A5 and FSTL1 likely play important roles in glucose metabolism in obese children.Immunohistochemistry techniques have been incorporated into surgical pathology for nearly a half-century and have since become intimately intertwined with its practice. In the realm of breast pathology, immunohistochemistry serves several purposes, including providing crucial prognostic and predictive data. Among its other applications, assessment of stromal invasion and establishment of mammary origin are crucial from a diagnostic standpoint. In these regards, sole reliance on immunohistochemistry may lead to misdiagnosis. In this review, we highlight pitfalls of immunohistochemistry commonly encountered in the practice of breast pathology and emphasize the importance of careful histopathological evaluation.Over the last decade, lead halide perovskites have attracted significant research attention in the field of photovoltaics, light-emitting devices, photodetection, ionizing radiation detection, etc, owing to their outstanding optoelectrical properties. However, the commercial applications of lead-based perovskite devices are restricted due to the poor ambient stability and toxicity of lead. The encapsulation of lead-based devices can reduce the possible leakage of lead. However, it is hard to ensure safety during large-scale production and long-term storage. Recently, considerable efforts have been made to design lead-free perovskites for different optoelectronic applications. Metal halide double perovskites with the general formula of A2MIMIIIX6or A2MIVX6could be potentially considered as green and stable alternatives for different optoelectronic applications. In this review article, we focus on the recent progress and findings on lead-free halide double perovskites for x-ray and UV-vis photodetection applications. Lead-free halide double perovskite has recently drawn a great deal of attention for superior x-ray detection due to its high absorption coefficient, large carrier mobility-lifetime product, and large bulk resistance. In addition, these materials exhibit good performance in photodetection in the UV-vis region due to high photocarrier generation and efficient carrier separation. In this review, first, we define the characteristics of lead-free double perovskite materials. The fundamental characteristics and beneficial properties of halide perovskites for direct and indirect x-ray detection are then discussed. We comprehensively review recent developments and efforts on lead-free double perovskite for x-ray detection and UV-vis photodetection. We bring out the current challenges and opportunities in the field and finally present the future outlook for developing lead-free double perovskite-based x-ray and UV-vis photodetectors for practical applications.Designing hydrogel-based constructs capable of adjusting immune cell functions holds promise for skin tissue regeneration. Mesenchymal stem cell (MSC)-derived small extracellular vesicles (sEVs) have attracted increasing attention owing to their anti-inflammatory and proangiogenic effects. Herein, we constructed a biofunctional hydrogel in which MSC-derived sEVs were incorporated into the injectable hyaluronic acid hydrogel, thus endowing the hydrogel with immunomodulatory effects. When implanted onto the wound site in a mouse large skin injury model, this functional hydrogel facilitates wound healing and inhibits scar tissue formation by driving macrophages towards an anti-inflammatory and anti-fibrotic (M2c) phenotype. Further investigation showed that the M2c-like phenotype induced by MSC-derived sEVs markedly inhibited the activation of fibroblasts, which could result in scarless skin wound healing. Taken together, these results suggest that modulation of the immune response is a promising and efficient approach to prevent fibrotic scar formation.Active enhancement of the optical absorption coefficient to improve the light converting efficiency of thin-film solar cell materials is crucial to develop the next-generation solar cell devices. Here we report first-principles calculations with generalized gradient approximation to study the optoelectronic properties of pristine and divacancy (DV) blue phosphorene (BlueP) thin films under structural deformation. We show that instead of formingsp-like covalent bonds as in the pristine BlueP layer, a DV introduces two particular dangling bonds between the voids. Using a microscopic (non-) affine deformation model, we reveal that the orbital hybridization of these dangling bonds is strongly modified in both the velocity and vorticity directions depending on the type of deformation, creating an effective light trap to enhance the material absorption efficiency. Furthermore, this successful light trap is complemented by a clear signature ofσ+πplasmon when a DV BlueP layer is slightly compressive. These results demonstrate a practical approach to tailor the optoelectronic properties of low-dimensional materials and to pave a novel strategy to design functionalized solar cell devices from the bottom-up with selective defects.Autorotating samaras have evolved to propagate successfully to their germination sites with the help of wind. This wind, in turn, is inherently unsteady across an extensive range of scales in the atmospheric boundary layer. To generate lift, samaras rely on the formation of a stably-attached leading-edge vortex (LEV) on the suction side of their wings. The kinematics of autorotating samaras experiencing gusts were examined experimentally in order to provide insights into the aerodynamic mechanisms responsible for successful propagation. The gust response of seven mature Boxelder Maple (Acer negundo) samaras was investigated using a small unsteady wind tunnel able to create vertical gusts. Interestingly, the samaras were found to have a stable tip-speed ratio (λ) during the gust phase, thus suggesting that the LEV remained stably-attached. Inspired by samaras, we designed a three-bladed rotor that incorporates key aerodynamic and geometric properties of samaras so as to exhibit a stably-attached LEV. The gust response of the samara-inspired rotor was examined using a towing-tank facility. The gust was emulated in the towing tank by accelerating the rotor from an initial steady speed to a final steady speed. Different gust intensities were tested by varying the rotor's normalized inertia number (I*) by systematically increasing the rotor moment of inertia (I). Similar to the natural samaras, the rotor exhibited a robust tip-speed ratio during all simulated gusts. The rotor's tip-speed ratio increased by a maximum of 11% and 6% during the slowest and fastest simulated gusts, respectively. By maintaining a stable tip-speed ratio during the gust, the samara-inspired rotor is thought to maintain stable LEVs resulting in stable autorotation. Therefore, by learning from the samara-inspired rotor, we suggest that samaras propagate successfully from their parent trees in unsteady (realistic) environments in part due to their robust autorotation properties.The use of microbial adsorption for metal ions to prepare novel carbon-supported metal nanomaterials has attracted growing research attention. However, the relationship between the adsorbed metal content and catalytic performance of the resulting nanomaterials is unclear. In this work,Pichia pastoris residueswas utilized to adsorb Ce(Ⅲ) at different metal ion concentrations, and then CeO2@C nanomaterials were prepared by pyrolysis. The effects of solution pH and adsorption behavior were investigated. The prepared nanostructures were characterized using electron microscopy and different spectroscopy methods, and their catalytic performances in the removal of salicylic acid from solution by catalytic ozonation were invested. The microbial residue had a metal uptake of 172.00 ± 2.82 mg· g-1at pH 6. In addition, the efficiency of total organic carbon (TOC) removal increased from 21.54% to 34.10% with an increase in metal content in the catalysts from 0 mg· g-1to 170.05 mg· g-1. After pyrolysis, the absorbed Ce(Ⅲ) metal transformed to CeO2metal nanoparticles embedded in a carbon matrix and had a core-shell CeO2@C structure. Therefore, this work not only reveals a relationship between metal content and catalytic performance, but also provides an approach for studying performance of materials with different metal contents loaded on various carriers.First-principles calculations are used to study the structure, magnetism and mechanical anisotropy properties of M6C (M = Fe, Mo) carbides. The stability of alloy carbide M6C can be improved when Mo atoms occupy the 48f Wyckoff position. Fe3Mo3C with Mo atoms occupying 48f position and Fe atoms occupying 16d and 32e positions has the best structural stability. The magnetic moment is triggered when the Fe content is approximately 0.5, suggesting that there exists a critical value between the paramagnetic nature and ferromagnetism. Carbides with Fe content above 0.5 have stronger magnetism. Higher Fe content corresponds to the stronger chemical bonding of carbides, resulting in improved elastic properties when Mo atoms are held in 48f position. The special carbides Fe4Mo2C and Fe3Mo3C (Fe at 48f site, Mo at 16d and 32e sites) correspond to the excellent mechanical properties. These results are helpful in providing a theoretical foundation of the possible direction for the advances of the excellent physical properties in Mo-containing steel.Objective. In people with a cervical spinal cord injury (SCI) or degenerative diseases leading to limited motor function, restoration of upper limb movement has been a goal of the brain-computer interface field for decades. Recently, research from our group investigated non-invasive and real-time decoding of continuous movement in able-bodied participants from low-frequency brain signals during a target-tracking task. To advance our setup towards motor-impaired end users, we consequently chose a new paradigm based on attempted movement.Approach. Here, we present the results of two studies. During the first study, data of ten able-bodied participants completing a target-tracking/shape-tracing task on-screen were investigated in terms of improvements in decoding performance due to user training. In a second study, a spinal cord injured participant underwent the same tasks. To investigate the merit of employing attempted movement in end users with SCI, data of the spinal cord injured participant were recorded twice; once within an observation-only condition, and once while simultaneously attempting movement.
