Vedeljimenez5893

China's rising in scientific research output is impressive. The academic community is curious about the time when the cross-over in the number of annual scientific publication production between China and the USA can happen. By using Web of Science Core Collection's Science Citation Index Expanded database, this study finds that China still ranks the second in the production of SCI-indexed publications in 2019 but may leapfrog the USA to be the first in 2020 or 2021, if all document types are considered. Comparatively, China has already overtaken the USA and been the largest SCI-indexed original research article producer since 2018. However, China still lags behind the USA regarding the number of review paper production. In general, quantitative advantage does not equal quality or impact advantage. We think that the USA will continue to be the global scientific leader for a long time.The care for patients suffering from cardiopulmonary arrest in a context of a COVID-19 pandemic has particularities that should be highlighted. selleck compound The following recommendations from the Brazilian Association of Emergency Medicine (ABRAMEDE), the Brazilian Society of Cardiology (SBC) and the Brazilian Association of Intensive Medicine (AMIB) and the Brazilian Society of Anesthesiology (SBA), associations and societies official representatives of specialties affiliated to the Brazilian Medical Association (AMB), aim to guide the various assistant teams, in a context of little solid evidence, maximizing the protection of teams and patients. It is essential to wear full Personal Protective Equipment (PPE) for aerosols during the care of Cardiopulmonary Resuscitation (CPR) and it is imperative to consider and treat the potential causes in these patients, especially hypoxia and arrhythmias caused by changes in the QT interval or myocarditis. The installation of an advanced invasive airway must be obtained early and the use of High Efficiency Particulate Arrestance (HEPA) filters at the interface with the valve bag is mandatory; situations of occurrence of CPR during mechanical ventilation and in a prone position demand peculiarities that are different from the conventional CPR pattern. Faced with the care of a patient diagnosed or suspected of COVID-19, the care follows the national and international protocols and guidelines 2015 ILCOR (International Alliance of Resuscitation Committees), AHA 2019 Guidelines (American Heart Association) and the Update of the Cardiopulmonary Resuscitation and Emergency Care Directive of the Brazilian Society of Cardiology 2019.Shelter in place orders (SIPOs) require residents to remain home for all but essential activities. Between March 19 and April 20, 2020, 40 states and the District of Columbia adopted SIPOs. This study explores the impact of SIPOs on health, with particular attention to heterogeneity in their impacts. First, using daily state-level social distancing data from SafeGraph and a difference-in-differences approach, we document that adoption of a SIPO was associated with a 9 to 10 percent increase in the rate at which state residents remained in their homes full-time. Then, using daily state-level coronavirus case data collected by the Centers for Disease Control and Prevention, we find that approximately three weeks following the adoption of a SIPO, cumulative COVID-19 cases fell by approximately 53.5 percent. Event-study analyses confirm common COVID-19 case trends in the week prior to SIPO adoption and show that SIPO-induced case reductions grew larger over time. However, this average effect masks important heterogeneity across states - early adopters and high population density states appear to reap larger benefits from their SIPOs. Finally, we find that statewide SIPOs were associated with a reduction in coronavirus-related deaths, but estimated mortality effects were imprecisely estimated.We investigate state-dependent effects of fiscal multipliers and allow for endogenous sample splitting to determine whether the U.S. economy is in a slack state. When the endogenized slack state is estimated as the period of the unemployment rate higher than about 12%, the estimated cumulative multipliers are significantly larger during slack periods than nonslack periods and are above unity. We also examine the possibility of time-varying regimes of slackness and find that our empirical results are robust under a more flexible framework. Our estimation results point out the importance of the heterogenous effects of fiscal policy and shed light on the prospect of fiscal policy in response to economic shocks from the current COVID-19 pandemic. (JEL C32, E62, H20, H62).It is a puzzle as to why more severe haze formed during the New Year Holiday in 2020 (NYH-20), when China was in an unprecedented state of shutdown to contain the coronavirus (COVID-19) outbreak, than in 2019 (NYH-19). We performed a comprehensive measurement and modeling analysis of the aerosol chemistry and physics at multiple sites in China (mainly in Shanghai) before, during, and after NYH-19 and NYH-20. Much higher secondary aerosol fraction in PM2.5 were observed during NYH-20 (73%) than during NYH-19 (59%). During NYH-20, PM2.5 levels correlated significantly with the oxidation ratio of nitrogen (r2 = 0.77, p less then 0.01), and aged particles from northern China were found to impede atmospheric new particle formation and growth in Shanghai. A markedly enhanced efficiency of nitrate aerosol formation was observed along the transport pathways during NYH-20, despite the overall low atmospheric NO2 levels.During the COVID-19 outbreak that took place in early 2020, the economic activities in China were drastically reduced and accompanied by a strong reduction in the emission of primary air pollutants. On the basis of measurements made at the monitoring stations operated by the China National Environmental Monitoring Center, we quantify the reduction in surface PM2.5, NO2, CO and SO2 concentrations in northern China during the lockdown, which started on 23 January 2020. We find that, on the average, the levels of surface PM2.5 and NO2 have decreased by approximately 35 and 60 percent, respectively, between the period 1-22 January 2020 and the period 23 January-29 February 2020. At the same time, the mean ozone concentration has increased by a factor 1.5-2. In urban area of Wuhan, where drastic measures were adopted to limit the spread of the coronavirus, similar changes in the concentrations of PM2.5, NO2 and ozone are found.Spaceborne NO2 column observations from two high-resolution instruments, TROPOMI onboard Sentinel-5 Precursor and OMI on Aura, reveal unprecedented NO2 decreases over China, South Korea, Western Europe and the U.S. as a result of public health measures enforced to contain the coronavirus disease outbreak (Covid-19) in January-April 2020. The average NO2 column drop over all Chinese cities amounts to -40% relative to the same period in 2019, and reaches up to a factor of ~2 at heavily hit cities, e.g. Wuhan, Jinan, while the decreases in Western Europe and the U.S. are also significant (-20 to -38%). In contrast with this, although Iran is also strongly affected by the disease, the observations do not show evidence of lower emissions, reflecting more limited health measures.This article will compare the collection of materials for the Saturn V documentation project under NAS8-21321 in 1968 to standard processes for collecting space history today. A case study of The Saturn V grant outlines the benefits of collecting research material in real time. This case study is compared to the findings compiled at the 2018 conference "To Boldly Preserve Archiving for the Next Half-Century of Spaceflight." The findings of this conference found that collecting space history is often fragmented by three factors early space actors are in the twilight of their careers and loss of historical memories and materials is imminent, there is a vast expansion of the number of actors in the space industry which makes collection more difficult, and that the digital age has changed both the nature of the material and the methods by which LAMS collect them. Libraries, Archives, and Museums (LAMs) can and should develop a collaborative approach to collecting space history and ensure that acquisition and preservation of these materials goes beyond one small step and is instead one giant leap.Chromone derivatives possess a spectrum of biological activities. Chromone has been recognized as a privileged structure for new drug invention and development. Substitution pattern of chromone scaffold determines different type of biological activities. The type, number and position of substituents connected to the chromone core play a vital role in determining pharmacological activities. In the present review, we have discussed new chromone derivatives as anticancer, anti-diabetic, antimicrobial, anti-inflammatory, antioxidant and as anti-Alzheimer agents. This review deals with the chromone derivatives prepared by combining chromone molecule with various natural and synthetic pharmacophores and pharmacological activities presented by them. The main aim is to highlight the diversified pharmacological activities exhibited by chromone hybrid molecules during the last eight to ten years.Several decades elapsed between the first descriptions of G-quadruplex nucleic acid structures (G4s) assembled in vitro and the emergence of experimental findings indicating that such structures can form and function in living systems. A large body of evidence now supports roles for G4s in many aspects of nucleic acid biology, spanning processes from transcription and chromatin structure, mRNA processing, protein translation, DNA replication and genome stability, and telomere and mitochondrial function. Nonetheless, it must be acknowledged that some of this evidence is tentative, which is not surprising given the technical challenges associated with demonstrating G4s in biology. Here I provide an overview of evidence for G4 biology, focusing particularly on the many potential pitfalls that can be encountered in its investigation, and briefly discuss some of broader biological processes that may be impacted by G4s including cancer.In-vehicle crowding on public transportation is a serious problem that transportation planners must address. Recent studies have emphasized that in-vehicle crowding impacts travelers' stress and health, while other studies have investigated how daily travel affects subjective well-being (SWB). Based on the findings of these studies, we provide useful insights into the value of a reduction in crowding in terms of SWB. The other factor we should consider is adaptation, as the effects of travel discomfort disappear after travelers become accustomed to them. In this paper, we analyzed the direct and stress-related indirect effects of dissatisfaction with in-vehicle crowding on life satisfaction, focusing on whether these effects differ by the length of time commuters have been using trains. Using a sample of 8296 train commuters in Tokyo, we found that (1) dissatisfaction with in-vehicle crowding directly lowers life satisfaction among some groups of short-term train commuters and (2) dissatisfaction with in-vehicle crowding indirectly lowers life satisfaction through stress and health, regardless of whether commuters have used trains for more or less than one year.