Covingtonsloth7612

Congenital lung malformations (CLM) include a complex range of developmental abnormalities. Currently, most are diagnosed prenatally or during early childhood.

to investigate clinical and imaging findings of congenital lung malformations in children.

Retrospective study of CLM diagnosed between 2000 and 2017 at the pediatric and neonatology department of Hedi Chaker Hospital. Analysis of clinical spectrum, diagnosis tools, and radiological appearances.

Twenty seven cases of CLM have been investigated 8 congenital lobar emphysema, 8 congenital cystic adenomatoid malformation, 8 pulmonary sequestrations, 2 bronchogenic cysts, and 1 hybrid lesion. Five (18,5%) patients were diagnosed antenatally and 22 (81,4%) postnatally. Symptoms occurred at a mean age of 9 months Respiratory distress (11 cases), wheezing (4 cases), and pneumonia (7 cases). Antenatal ultrasound features include echogenic masses within the chest (2cases), the presence of cysts (2cases), unilateral pleural effusion (1 case) and hydramnios (2cases). A computed tomography scan was performed in all patients with a radio-histological concordance of 96%.

Twenty seven cases of CLM have been investigated 8 congenital lobar emphysema, 8 congenital cystic adenomatoid malformation, 8 pulmonary sequestrations, 2 bronchogenic cysts, and 1 hybrid lesion. Five (18,5%) patients were diagnosed antenatally and 22 (81,4%) postnatally. Symptoms occurred at a mean age of 9 months Respiratory distress (11 cases), wheezing (4 cases), and pneumonia (7 cases). Antenatal ultrasound features include echogenic masses within the chest (2cases), the presence of cysts (2cases), unilateral pleural effusion (1 case) and hydramnios (2cases). A computed tomography scan was performed in all patients with a radio-histological concordance of 96%.

Spontaneous retinal reattachment is very rare in the natural evolution of rhegmatogenous retinal detachment and it is often undervalued.

To report some cases of this affection.

A retrospective study was conducted reporting five eyes of five patients who presented for acute visual loss in relation with a confirmed rhegmatogenous retinal detachment. Surgical care was delayed because of bacterial or viral conjunctivitis. Following this delay, the preoperative examination rapported a spontaneous retinal reattachment. Each patient underwent Laser exclusion of the dehiscence and a regular follow up clinical examination and OCT.

The incidence of spontaneous retinal reattachment is 3.2% among examined and treated rhegmatogenous retinal detachments in our department during this period. The age of our patients ranged between 20 and 67 years. Retinal detachment was subtotal in all cases. Retinal break was unique in four cases and mostly located in the superior retina. Proliferative vitreoretinopathy was low graded in all cases (A and B).

The diagnosis of spontaneous reattachment DRR was often carried out retrospectively on the basis offundus evocative examination signs. According to many authors, it is more observed in myopic eye and if detachment is inferior. In our series, the low PVR seems to have a principal role in physiopathology.

The diagnosis of spontaneous reattachment DRR was often carried out retrospectively on the basis offundus evocative examination signs. According to many authors, it is more observed in myopic eye and if detachment is inferior. In our series, the low PVR seems to have a principal role in physiopathology.

Paclitaxel (PTX) is an anticancer drug used in the treatment of many cancer , alone or in combination with other anti-tumors. It has a narrow therapeutic range, a large inter and intra-individual pharmacokinetic variability and haematological toxicity. The most effective pharmacokinetic parameter seems to be the time during which the plasma concentration is over 0.05 μmol/L.

To develop and validate a new method for PTX quantitation in plasma using HPLC with UV/visible detection.

A rapid HPLC-UV method was developed for the determination of PTX level in plasma. All solvents used were HPLC grade.

After liquid-liquid extraction, chromatographic separation was achieved using an RP 18 (250 mm) column. The mobile phase was composed of acetonitrile and 0.1 M potassium dihyrogenophosphate (49/51) (v/v). Clonazepam was used as internal standard. This technique was linear over the range 50 ng/mL to 1500 ng/mL (r= 0.998). The evaluation of precision showed that our method is repeatable with a within-day coefficient of variation (CV) ranging from 6.94 to 18.78 % and reproducible for three studied concentrations low, medium and high with day-to-day CV of 14.92, 10.46 and 11.8% respectively. Under these conditions, each analysis required no longer than 12.81 min.

We have developed and validate a new assay for PTX monitoring using HPLC with UV detection which is sensible, specific, reliable and easy to carry out in clinical use for its therapeutic drug monitoring.

We have developed and validate a new assay for PTX monitoring using HPLC with UV detection which is sensible, specific, reliable and easy to carry out in clinical use for its therapeutic drug monitoring.

Stigmatization of patients with mental illness is a worldwide phenomenon which can jeopardize help seeking and treatment adherence and contribute to low self-esteem and quality of life.

To assess stigmatization as perceived and experienced by patients with severe mental illness in Tunisia.

This is a cross-sectional descriptive study conducted at Razi Hospital La Manouba, Tunisia in clinically stabilized patients with bipolar disorder and schizophrenia followed at our outpatient clinic. Aminoguanidine hydrochloride Patients gave their opinion on a total of 31 statements related to stigma relevant to the Tunisian cultural context.

The study sample consisted of 105 patients with an average age of 38.3 years and a sex ratio of 1.5. Negative perceptions or experiences prevailed in 19 out of 31 statements, mostly referring to received and endorsed stigma.Study participants expressed apprehension about disclosure of mental illness, mainly due to fears about family reputation and job opportunities, however, a large majority actually disclosed their mental illness to their surroundings.