Rosenthalhu3287
Migrant and immigrant farmworkers are cornerstones to food security and production in many nations. In the United States, farmworkers have been disproportionately impacted by COVID-19. Because they are considered essential workers, vaccines may be made imminently available to them and offer an opportunity to reduce these COVID-19-related impacts. It is essential for a successful vaccination campaign to address the unique challenges arising from this workforce's inherently mobile nature and limited access to healthcare. Proposed strategies to overcome these challenges include ensuring farmworkers are prioritized in vaccine allocation and provided cost-free vaccines at convenient locations through partnerships among health authorities, community- and faith-based groups, and health centers with trusted community relationships. Further, a portable immunization record should be used, and coordination of care continued when a farmworker moves to a new geographic location. If implemented well, vaccinating farmworkers can reduce the COVID-19 disease burden among these essential workers, improve public health, and protect food and agriculture production.
Antibodies against leucine-rich glioma-inactivated 1 (LGI1-Abs) characterize a limbic encephalitis (LE) strongly associated with HLA-DRB1*0701, although some patients lack LGI1-Abs in CSF or do not carry this allele. Whether they represent a different subtype of disease or have different prognoses is unclear.
Retrospective analysis of clinical features, IgG isotypes, and outcome according to LGI1-Ab CSF positivity and DRB1*0701 in a cohort of anti-LGI1 LE patients.
Patients with LGI1-Abs detected in both CSF and serum (105/134, 78%) were compared with those who were CSF negative (29/134, 22%). Both groups had similar clinical features and serum levels, but CSF-positive patients had shorter diagnostic delay, more frequently hyponatremia, inflammatory CSF, and abnormal MRI (
< 0.05). Human leukocyte antigen (HLA) genotyping was performed in 72/134 (54%) patients and 63/72 (88%) carried DRB1*0701. Noncarriers (9/72, 12%) were younger, more commonly women, and had less frequently psychiatric and fronta response. Long-term outcome depends mostly on demographic characteristics and the intensity of the intrathecal synthesis.
Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare sequela of acute pulmonary embolism that is treatable when recognized. Awareness of this disease has increased with recent advancements in therapeutic options, but delays in diagnosis remain common, and diagnostic and treatment guidelines are often not followed. Data gathered from international registries have improved our understanding of CTEPH, but these data may not be applicable to the US population owing to differences in demographics and medical practice patterns.
The US CTEPH Registry (US-CTEPH-R) was developed to provide essential information to better understand the demographics, risk factors, evaluation, and treatment of CTEPH in the United States, as well as the short- and long-term outcomes of surgical and nonsurgical therapies in the modern treatment era.
Thirty sites throughout the United States enrolled 750 subjects in this prospective, longitudinal, observational registry of patients newly diagnosed with CTEPH. Enrollment crT02429284; https//www.clinicaltrials.gov/ct2/show/NCT02429284.
DERR1-10.2196/25397.
DERR1-10.2196/25397.
The tendency of parents to consume alcohol during the COVID-19 pandemic is likely to be moderated by pandemic-related stress combined with the ongoing demands of childcare and home-based education, which are reported to be more burdensome for females than males.
The purpose of this study was to describe alcohol-related content posted by mothers on Instagram during the COVID-19 pandemic.
Using two popular hashtags, #momjuice and #winemom, 50 Instagram posts on each were collected from the "top posts" tab. The coding categories were created inductively and were as follows displays alcohol (drinking/holding alcohol or alcohol itself), person is making alcoholic beverages, type of alcohol featured or discussed, highlights anxiety and/or depression/mental state, highlights struggling (in general), highlights parenting challenges, encourages alcohol consumption, discourages alcohol consumption, features a person wearing clothing or shows products promoting alcohol, promotes alcohol rehabilitation, highlights ficant (P=.0499).
The findings of this investigation suggest that though these hashtags ostensibly exist to valorize excess alcohol consumption, they may be serving as a support system for mothers who are experiencing increased burdens and role stress during the pandemic. Given the strains placed on mothers overall and especially during the COVID-19 pandemic, efforts must be taken to increase access to and affordability of telehealth-based mental health care.
The findings of this investigation suggest that though these hashtags ostensibly exist to valorize excess alcohol consumption, they may be serving as a support system for mothers who are experiencing increased burdens and role stress during the pandemic. Given the strains placed on mothers overall and especially during the COVID-19 pandemic, efforts must be taken to increase access to and affordability of telehealth-based mental health care.Type 1 diabetes management can be challenging for children and their families. To address psychosocial concerns for parents of youth with type 1 diabetes, we developed two parent-focused interventions to reduce their diabetes distress and fear of hypoglycemia. Our team conducted several of these interventions during the early stages of the COVID-19 pandemic and recognized a need to make timely adjustments to our interventions. In this viewpoint article, we describe our experience conducting these manualized treatment groups during the pandemic, the range of challenges and concerns specific to COVID-19 that parents expressed, and how we adjusted our approach to better address parents' treatment needs.[This corrects the article DOI 10.2196/15171.].Neuroblastoma is a pediatric cancer with high morbidity and mortality. Accurate survival prediction of patients with neuroblastoma plays an important role in the formulation of treatment plans. In this study, we proposed a heterogeneous ensemble learning method to predict the survival of neuroblastoma patients and extract decision rules from the proposed method to assist doctors in making decisions. After data preprocessing, five heterogeneous base learners were developed, which consisted of decision tree, random forest, support vector machine based on genetic algorithm, extreme gradient boosting and light gradient boosting machine. Subsequently, a heterogeneous feature selection method was devised to obtain the optimal feature subset of each base learner, and the optimal feature subset of each base learner guided the construction of the base learners as a priori knowledge. Furthermore, an area under curve-based ensemble mechanism was proposed to integrate the five heterogeneous base learners. Finally, the proposed method was compared with mainstream machine learning methods from different indicators, and valuable information was extracted by using the partial dependency plot analysis method and rule-extracted method from the proposed method. Experimental results show that the proposed method achieves an accuracy of 91.64%, recall of 91.14%, and AUC of 91.35% and is significantly better than the mainstream machine learning methods. In addition, interpretable rules with accuracy higher than 0.900 and predicted responses are extracted from the proposed method. Our study can effectively improve the performance of the clinical decision support system to improve the survival of neuroblastoma patients.Manual scoring of sleep stages from polysomnography (PSG) records is essential to understand the sleep quality and architecture. Since the PSG requires specialized personnel, a lab environment, and uncomfortable sensors, non-contact sleep staging methods based on machine learning techniques have been investigated over the past years. In this study, we propose an attention-based bidirectional long short-term memory (Attention Bi-LSTM) model for automatic sleep stage scoring using an impulse-radio ultra-wideband (IR-UWB) radar which can remotely detect vital signs. Sixty-five young (30.0 8.6 yrs.) and healthy volunteers underwent nocturnal PSG and IR-UWB radar measurement simultaneously; From 51 recordings, 26 were used for training, 8 for validation, and 17 for testing. Sixteen features including movement-, respiration-, and heart rate variability-related indices were extracted from the raw IR-UWB signals in each 30-s epoch. Sleep stage classification performances of Attention Bi-LSTM model with optimized hyperparameters were evaluated and compared with those of conventional LSTM networks for same test dataset. In the results, we achieved an accuracy of 82.6 6.7% and a Cohen's kappa coefficient of 0.73 0.11 in the classification of wake stage, REM sleep, light (N1+N2) sleep, and deep (N3) sleep which is significantly higher than the conventional LSTM networks (p less then 0.01). Moreover, the classification performances were higher than those reported in comparative studies, demonstrating the effectiveness of the attention mechanism coupled with bi-LSTM networks for the sleep staging using cardiorespiratory signals.Autonomic nervous system (ANS) can maintain homeostasis through the coordination of different organs including heart. The change of blood glucose (BG) level can stimulate the ANS, which will lead to the variation of Electrocardiogram (ECG). Considering that the monitoring of different BG ranges is significant for diabetes care, in this paper, an ECG-based technique was proposed to achieve non-invasive monitoring with three BG ranges low glucose level, moderate glucose level, and high glucose level. For this purpose, multiple experiments that included fasting tests and oral glucose tolerance tests were conducted, and the ECG signals from 21 adults were recorded continuously. Furthermore, an approach of fusing density-based spatial clustering of applications with noise and convolution neural networks (DBSCAN-CNN) was presented for ECG preprocessing of outliers and classification of BG ranges based ECG. Also, ECG's important information, which was related to different BG ranges, was graphically visualized. The result showed that the percentages of accurate classification were 87.94% in low glucose level, 69.36% in moderate glucose level, and 86.39% in high glucose level. Moreover, the visualization results revealed that the highlights of ECG for the different BG ranges were different. In addition, the sensitivity of prediabetes/diabetes screening based on ECG was up to 98.48%, and the specificity was 76.75%. Therefore, we conclude that the proposed approach for BG range monitoring and prediabetes/diabetes screening has potentials in practical applications.In this article, we develop a hybrid physics-informed neural network (hybrid PINN) for partial differential equations (PDEs). Lonafarnib We borrow the idea from the convolutional neural network (CNN) and finite volume methods. Unlike the physics-informed neural network (PINN) and its variations, the method proposed in this article uses an approximation of the differential operator to solve the PDEs instead of automatic differentiation (AD). The approximation is given by a local fitting method, which is the main contribution of this article. As a result, our method has been proved to have a convergent rate. This will also avoid the issue that the neural network gives a bad prediction, which sometimes happened in PINN. To the author's best knowledge, this is the first work that the machine learning PDE's solver has a convergent rate, such as in numerical methods. The numerical experiments verify the correctness and efficiency of our algorithm. We also show that our method can be applied in inverse problems and surface PDEs, although without proof.
