Behrensjochumsen0059

During the COVID-19 pandemic, various restrictions forced people around the world to socially isolate. People were asked to stay at home and were largely unable to do many of the activities that they derived meaning from. Since meaning is often related to mental health, these restrictions were likely to decrease mental health. The current study aimed to examine these effects and additionally benefit individuals' mental health by making their meaning salient. Specifically, the goal of the research was to design an intervention that could counter the potential negative effects of social distancing. We recruited a total of 96 U.S.A. residents (M age  = 34.45, 92.7% Female) and assigned them to either the control group or to a meaning salience intervention. That is, participants either focused on the meaning of their daily activities (n = 45) or did not participate in any study-related activities during the week (n = 51). They completed various measures of mental health before and after this experimental period. Results suggested that the control group reported significantly greater anxiety, depression, and stress at the end of the week. In contrast, the experimental group reported less anxiety and trended toward less depression and stress at the end of that same week. In all, results suggest that simply focusing on one's daily activities and the meaning found in them protected people from the otherwise detrimental effects of the restrictions. This provides a promising and simple intervention that may assist both individuals and practitioners aiming to improve mental health, especially in challenging times.

Although blood concentration of biologics is an important composition of disease management in inflammatory bowel disease (IBD) patients, complexity and uncertainty of biological management encourage many disputes in predicting the outcome of IBD patients through blood concentration of biologics.

To verify the predictive value of blood concentration of biologics on endoscopic inactivity in IBD patients under different situations.

We searched PubMed/MEDLINE, Embase, and Web of Science up to May 2020 and identified IBD patients as the research cohort as well as the correlations between blood concentration of biologics and endoscopic inactivity in IBD patients as the research direction.

A total of 23 articles with 30 clinical studies and 1939 IBD patients were included. The predictive cut-off value of blood concentration of infliximab on mucosal healing should be 2.7-10.6 μg/mL in IBD. Blood concentration of infliximab reaching 5.0-12.7 μg/mL or more increased the probability of fistula healing/closure i drug monitoring intensively contributes to precise therapy.

1,3-beta-D-glucan (BG) is a ubiquitous cell wall component of gut micro-organisms. Tween80 We hypothesized that the serum levels of BG could reflect active intestinal inflammation in patients with inflammatory bowel disease.

To determine whether the serum BG concentrations correlate with intestinal inflammation.

A prospective observational study was performed in a tertiary referral center, from 2016 to 2019, in which serum BG was determined in 115 patients with Crohn's disease (CD), 51 with ulcerative colitis (UC), and 82 controls using a photometric detection kit. Inflammatory activity was determined by ileocolonoscopy, histopathology, magnetic resonance enterography, and biomarkers, including fecal calprotectin (FC), C-reactive protein, and a panel of cytokines. The ability of BG to detect active

inactive disease was assessed using the area under the receiver operating characteristic curve. In subgroup analysis, serial BG was used to assess the response to therapeutic interventions.

The serum BG levels wt novel noninvasive approach for detecting mucosal inflammation and therapeutically monitoring inflammatory bowel diseases, particularly in CD.

Various surgical procedures have been described for gastrointestinal stromal tumors (GISTs) at the esophagogastric junction (EGJ) close to the Z-line. However, surgery for EGJ-GIST involving Z-line has been rarely reported.

To introduce a novel technique called conformal resection (CR) for open resection of EGJ-GIST involving Z-line.

In this retrospective study, 43 patients having GISTs involving Z-line were included. The perioperative outcomes of patients receiving CR (

= 18) was compared with that of proximal gastrectomy (PG) (

= 25).

CR was successfully performed in all the patients with negative microscopic margins. The mean operative time, time to first passage of flatus, and postoperative hospital stay was significantly shorter in the CR group (

< 0.05), while the intraoperative blood loss was similar in the two groups. The postoperative gastroesophageal reflux as diagnosed by esophageal 24-h pH monitoring and quality of life at 3 mo were significantly in favor of CR compared to PG (both

< 0.001). The 5-year disease-free survival between the two groups was similar (

= 0.163). The cut- off value for the determination of CR or PG was 7.0 mm above the Z-line (83.33% sensitivity, 84.00% specificity, 83.72% accuracy).

CR is safe and feasible for EGJ-GIST located within 7.0 mm above the Z-line.

CR is safe and feasible for EGJ-GIST located within 7.0 mm above the Z-line.

Liver injury is common and also can be fatal, particularly in severe or critical patients with coronavirus disease 2019 (COVID-19).

To conduct an in-depth investigation into the risk factors for liver injury and into the effective measures to prevent subsequent mortality risk.

A retrospective cohort study was performed on 440 consecutive patients with relatively severe COVID-19 between January 28 and March 9, 2020 at Tongji Hospital, Wuhan, China. Data on clinical features, laboratory parameters, medications, and prognosis were collected.

COVID-19-associated liver injury more frequently occurred in patients aged ≥ 65 years, female patients, or those with other comorbidities, decreased lymphocyte count, or elevated D-dimer or serum ferritin (

< 0.05). The disease severity of COVID-19 was an independent risk factor for liver injury (severe patients Odds ratio [OR] = 2.86, 95% confidence interval [CI] 1.78-4.59; critical patients OR = 13.44, 95%CI 7.21-25.97). The elevated levels of on-admission aspartate aminotransferase and total bilirubin indicated an increased mortality risk (

< 0.