Stougaardnielsen4711

reatment guidelines. Further research into the effect of weight loss surgery/medication to lower the risk of heart failure or mortality after a diagnosis of heart failure is needed.

Obesity should be recognised as a causal factor for development of heart failure, heart failure mortality, and all-cause mortality in treatment guidelines. Further research into the effect of weight loss surgery/medication to lower the risk of heart failure or mortality after a diagnosis of heart failure is needed.

Patinent multi-omics datasets are often characterized by a high dimensionality, however usually only for a small fraction of the features is informative, that is changes in their values is directly related to the disease outcome or patient survival. In medical sciences, in addition to a robust feature selection procedure, the ability to discover human-readable patterns in the analysed data is also desirable. To address this need, we created MAINE-Multi-omics Analysis and Exploration. The unique functionality of MAINE is the ability to discover multidimensional dependencies between the selected multi-omics features and event outcome prediction as well as patient survival probability. Learned patterns are visualized in the form of interpretable decision/survival trees and rules.

MAINE is freely available at maine.ibemag.pl as an online web application.

Supplementary data are available at Bioinformatics online.

Supplementary data are available at Bioinformatics online.

SIGNORApp is a Cytoscape 3 (3.8 and later) application that provides access to causal interactions annotated in the SIGNOR resource. The application builds networks that can be represented as weighted, signed, directed graphs, where nodes are interacting biological entities and edges represent causal interactions captured by expert curators from experiments reported in peer reviewed journals. Users can query the SIGNOR dataset with i) single or multiple entity name(s) or identifier(s) and optionally they may require to include in the output network their interacting partners; ii) browse pathways that are annotated in the SIGNOR resource; iii) extract the entire causal interactome. The app offers two visualizations modes one only displaying entity interactions and a second emphasizing the post translational modifications occurring as a consequence of the interaction. In addition, users can click on nodes and edges to access entity and interaction annotations. Causal information is available for three model organisms H. sapiens, M. musculus and R. norvegicus.

SIGNORApp has been developed for Cytoscape 3 (3.8 and later) in the Java programming language. The latest source code and the plugin can be found at https//github.com/SIGNORcysAPP/signor-app and https//apps.cytoscape.org/apps/signorapp, respectively.

Supplementary data are available at Bioinformatics online.

Supplementary data are available at Bioinformatics online.Cancer of the cervix is the fourth commonest malignancy in women worldwide and it also ranks fourth as the cause of cancer related mortality in women. Hypoxia is a common characteristic of solid tumours and cervical cancer is no exception. Hypoxia is associated with increased aggressiveness, risk of invasion and metastasis. Tumour hypoxia also results in resistance to both radiation therapy and chemotherapy leading to a poorer prognosis. In-vivo measurement of tumour hypoxia is vital in oncologic practice because it can predict outcome and identify patients with a worse prognosis. Mapping of tumour hypoxia may also help select patients that may benefit from applicable treatments. While traditional methods of measuring hypoxia such as the Eppendorf probe is considered the gold standard, it is invasive and technically demanding. Non-invasive methods of measuring tumourhypoxia are ideal. Positron emission tomography/computed tomography (PET/CT) imaging with nitro-imidazole-based tracers is a highly sensitive nucr further human studies with these tracers.The aim of this review is to discuss hypoxia and its impact in cancer of the cervix as well as to look into the progress made in hypoxia imaging in cancer of the cervix. This will focus on the tracers studied thus far and some of the challenges of hypoxia imaging.

The purpose of this study was to evaluate a standard 4-h imaging protocol for gastric emptying scintigraphy (GES) in detecting delayed gastric emptying (GE).

Gamma camera imaging was performed in the anterior and posterior views at 0, 0.5, 1, 1.5, 2, 2.5 and 4-h as per established Miami method (MIA) and National Standard Protocol (NSP), in accordance with the consensus guidelines of the ANMS/SNM [SNMMI] Societies. Patients (N=1002) received a standardized solid meal radiolabeled with 1mCi of technetium-99 (

Tc) sulfur colloid. Quantitative analysis was performed using geometric mean calculation of decay-corrected counts at each imaging time point, expressed as percent emptying or retention.

In our patient cohort, 21% had delayed GE at 4h, whereas 79% had normal emptying with less than 10% retention at 4h. There was a 25% increase in delayed GE studies at 4h versus 2h. From those patients who had delayed GE at 2h, 30% normalized at 4h, while 10% of patients with normal GE at 2h became delayed at 4h thushout additional imaging.Since hyperhomocysteinaemia (HHcys) is implicated as a risk factor for the development of neurodegeneration, and is associated with the development of metabolic diseases,we aimed at analysing the effect of homocysteine (Hcys) on regional fluorine-18-fluorodeoxyglucose (18F-FDG) brain metabolismin 51 controlled type 2 diabetic and in 48 non-DM obese participants. Plasma Hcys levels were measured by an immunoassay. Homocysteine-related 18F-FDG regional brain metabolism was evaluated applying 18F-FDG PET/CT using magnetic resonance imaging (MRI)-based brain template for statistical parametric mapping (SPM) analysis. Homocysteine-related decreased 18F-FDG uptake was shown in the right middle temporal gyrus in the whole population. Diabetics with Hcys above the reference limit expressed decreased glucose metabolismin the left calcarine cortex compared to the obese with HHcys. Regional metabolic alterations evoked on the basis of HHcys draw attention to the potential risk of neurodegeneration caused by metabolic disturbances.BACKGROUND This retrospective study was conducted at a single center and aimed to evaluate operative and postoperative outcomes in patients with spinal metastases using vertebrectomy and combined vertebrectomy and radiofrequency ablation (RFA). MATERIAL AND METHODS Patients diagnosed with spinal metastases between April 2009 and March 2016 (n=49) included patients who underwent vertebrectomy (n=26) and patients who underwent combined vertebrectomy and RFA (n=23). The characteristics of the 2 groups were similar in primary tumor types, comorbidities, Tomita score, vertebral involvement, preoperative bone pain, and neurologic deficit. RESULTS The results showed for the both groups that the visual analog scale (VAS) pain score was significantly decreased (P less then 0.05) and the neurological status was improved after treatment. Compared with the control group (vertebrectomy only), the combination group (combined vertebrectomy and RFA) had less intraoperative blood loss (P=0.002) and shorter operation time (P less then 0.001). The recurrence rate was lower (P=0.003) in the patients who received combined treatment, and the period of local recurrence was prolonged (P=0.030) in the combination group. CONCLUSIONS This retrospective study showed that the selective use of combined vertebrectomy and RFA significantly reduced surgical time and blood loss, improved recovery of neurologic deficit, and reduced the tumor recurrence rate in patients with spinal metastases.BACKGROUND Parathyroid carcinoma (PC) is an extremely rare endocrine malignancy, with a reported increase in incidence in the past decade. PC generally presents in an indolent fashion, featuring nonspecific symptoms associated with hypercalcemia. CASE REPORT Case 1 A 30-year-old man was admitted for symptoms associated with hypercalcemia and elevated parathyroid hormone (PTH). Imaging examinations showed the presence of a cervical nodular lesion. The patient underwent surgery, and the pathological diagnosis was PC. Case 2 A 45-year-old man with a history of hypothyroidism was referred to our Endocrinology Department for a cervical nodular lesion. A fine-needle aspiration was performed, and the result was suggestive of papillary carcinoma. selleck chemical Blood testing showed only mild hypercalcemia and PTH elevation, with no associated symptoms. The patient underwent surgery, and the histological examination confirmed the diagnosis of PC. Case 3 A 38-year-old man presented with diffuse bone pain and muscle weakness, severe hypercalcemia, high levels of PTH, and a cervical mass. The patient underwent surgery. Diagnostic pathology confirmed the diagnosis of PC. Five years later, the patient presented with a cutaneous metastasis, followed 1 year later by pulmonary metastases. CONCLUSIONS Most PCs are slow-growing tumors. Some of these tumors are diagnosed in association with hereditary syndromes. A clear distinction between benign and malignant lesions is not always simple because there is a lack of specific clinical distinguishing features of malignant lesions. Currently, surgical resection is the preferred approach; however, owing to the rarity of this condition, there is a void of high-quality data.

To present a new technique, RONA, for internal limiting membrane (ILM) peeling and show its comparable success rate in closure of large full thickness macular holes (FTMHs).

This prospective interventional case series was implemented from January 2018 to November 2019. Consecutive cases with large FTMH with an aperture size of more than 500 µm were included. RONA technique was used to make consecutive flaps; central border of which remained adherent to the FTMH edge. The emphasis is that the central border of all flaps should remain adherent to the FTMH edge, letting the flaps remain there spontaneously.

Seventeen eyes of 17 patients (4 males and 13 females; age 62.3 ± 7.8) were included. The mean size of opening and base of FTMH were 651.1 ± 141.1 µm (range 501 - 950) and 964.6 ± 383.8 µm (range 527 - 2098), respectively. One week after the surgery, complete closure of all FTMHs occurred with no hole reopening until the end of month 12. Mean BCVA at baseline and twelve months after surgery were 1.57 ± 0.30 logMAR and 0.75 ± .028 logMAR, respectively with statistically significant improvement (P<0.001).

The first advantage of this efficacious technique is that there is no need to manipulate FTMH edge or underneath tissues. Another and of course, the most important advantage of this technique over others is that there is no need to care about flap unfolding during the exchange stage.

The first advantage of this efficacious technique is that there is no need to manipulate FTMH edge or underneath tissues. Another and of course, the most important advantage of this technique over others is that there is no need to care about flap unfolding during the exchange stage.

To evaluate the mid-term outcomes of pars plana vitrectomy (PPV) performed for retinal detachment (RD) repair after Boston type 1 keratoprosthesis (KPro) implantation.

Retrospective chart review of KPro implanted at the Stein Eye Institute presenting with RD and treated by PPV. Functional success was defined as a postoperative visual acuity (VA) maintained within 2 Snellen lines of the CDVA measured before the development of the RD (baseline) and anatomical success as an attached retina after the PPV. Kaplan-Meyer survival analyses were performed.

Among the 224 KPro performed, 28 (15.2%) RD were identified, of which 21 (9.4%) were included. The mean follow-up was 42.5 ± 27.3 months. Vitreoretinal proliferation was present in 18/21 (85.7%) eyes. Surgical techniques were adapted to the complex anterior segment anatomy of KPro eyes. Anatomical success was achieved in 18/21 (85.7%) eyes. Functional success occurred in 17/21 (81.0%) eyes, and 5/21 (23.8%) eyes reached 20/400 or better VA at final follow-up. The KPro was retained in 11/21 (52.