Schofieldhoward9048

The oral health-promoting effects of green tea are attributed to its polyphenol components. Aim of this work was to systematically review the literature in search for clinical trials assessing green tea for managing periodontitis and caries.

Randomized clinical trials comparing the efficacy of green tea versus control groups in oral hygiene and gingival health; periodontitis; caries; periodontal pathogens number;

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spp. Meta-analysis and meta-regression analysis were performed.Literature searches were carried out using MedLine (PubMed), Scopus, and the Cochrane Library. Eighteen studies (870 subjects) were included.

Green tea treatment had medium positive effect size in reducing GI (SMD 0.50; 95%CI -0.02/1.01); PI (SMD 0.54; 95%CI 0.14/0.95); GBI (SMD 0.58; 95%CI -0.41/1.56) and BOP (SMD 0.52; 95%CI -0.57/1.60) in respect to the control group. Splitting to subgroups, green tea showed a small negative effect in the chlorhexidine control groups. Green tea treatment had medium positive effect size in reducing CAL (SMD 0.58; 95%CI -0.49/1.65) and large positive effect size in reducing PPD (SMD1.02; 95%CI 0.45/1.59).

Even if the results are encouraging, there is insufficient evidence to recommend the use of green tea formulation as first choice treatment for gingivitis, periodontitis and caries.

Even if the results are encouraging, there is insufficient evidence to recommend the use of green tea formulation as first choice treatment for gingivitis, periodontitis and caries.Sexual minority individuals (e.g., lesbian, gay, bisexual people) face sexual health inequalities related to their experiences with providers in sexual health care settings, yet few prior studies have focused on these experiences. In the current study, we analyzed qualitative interviews with a diverse sample of 58 sexual minority individuals from three age cohorts in the United States to explore sexual minority people's perspectives of sexual health care. Thematic content analysis revealed four key themes erasure, enacted stigma, felt stigma, and affirmative care. Subgroup differences in themes across gender, sexual identity, race/ethnicity, and age cohort were also assessed. Pictilisib supplier Women and genderqueer participants reported erasure in the context of identity dismissal in family planning conversations, and men reported felt stigma in the context of hyperawareness of sexual minority identity. Some sexual minority people of color also reported intersectional felt stigma as a result of multiple marginalized identities. Additionally, fewer men reported erasure compared to women or genderqueer people and fewer gay and lesbian participants reported erasure than bisexual or queer people. Implications of these findings include the need for more sexual minority health care initiatives and training and the development of affirmative care practices for sexual minority populations, including those with multiple marginalized identities.Parent stress has been associated with negative outcomes for youth and may be particularly high during adolescence. Mindfulness interventions have the potential to reduce parent stress and to improve parenting behavior and parent-child relationship quality. The present randomized controlled study examined effects of a parenting-focused mindfulness intervention, the Parenting Mindfully (PM) intervention, for highly stressed parents of adolescents. Eighty three mothers of 12-17 year olds reporting high stress were randomly assigned to the PM intervention or to a minimal-intervention Parent Education (PE) control group. At pre- and post-intervention, mothers reported on their mindfulness, stress, parenting stress, mindful parenting, and parent-adolescent relationship quality. At pre- and post-intervention, mothers' observed parenting behaviors and reported negative emotional responses to a laboratory parent-adolescent interaction task (PAIT) were also collected. Findings indicated that the PM intervention, compared to PE, increased mothers' mindfulness, reduced parenting stress in two domains, increased mindful parenting related to emotional awareness in parenting, and improved parent-adolescent relationship quality. For mothers of girls (but not mothers of boys), the PM intervention also decreased negative parenting behavior and decreased negative emotional responses in PAIT. Effects sizes were medium to large. In sum, findings support parenting-focused mindfulness training as a viable intervention strategy for highly-stressed parents.

Behavioral evidence suggests that parenting-focused mindfulness interventions can improve parenting practices and enhance family wellbeing, potentially operating through altered emotional processing in parents. However, the mechanisms through which parent mindfulness interventions achieve their positive benefits have not yet been empirically tested, knowledge which is key to refine and maximize intervention effects. Thus, as part of a randomized controlled trial, the present study examined the affective mechanisms of an 8-week parenting-focused mindfulness intervention, the Parenting Mindfully (PM) intervention, versus a minimal-intervention parent education control.

Twenty highly stressed mothers of adolescents completed pre- and post-intervention behavioral and fMRI sessions, in which mothers completed a parent-adolescent conflict interaction, fMRI emotion task, and fMRI resting state scan. Mothers reported on their mindful parenting, and maternal emotional reactivity to the parent-adolescent conflict ting interactions, illuminating potential neurobiological targets for future parent-focused intervention.

Mindful parenting and parenting cognitions likely have important linkages to each other and to parent-child communication, but these linkages have not been tested. In this article, we test the bidirectional linkages between mindful parenting and parenting cognitions (sense of competence, parent-centered attributions) and the underlying mediational processes that link them to parent-child communication (parental solicitation and youth disclosure).

Longitudinal, autoregressive cross-lagged models were run within a longitudinal sample of rural and suburban early adolescents and their mothers (

= 421; mean adolescent age = 12.14, 46% male, 73% white).

Significant bidirectional linkages were found between mindful parenting and parenting cognitions across Time 1 and Time 2. Greater mindful parenting at Time 1 was associated with more positive parenting cognitions (e.g., greater perceptions of parental competence and fewer negative parent-centered attributions or self-blame) at Time 2. More positive parenting cognitions at Time 1 were also associated with greater levels of mindful parenting at Time 2. Mindful parenting at Time 2 mediated the association between parenting cognitions (both parent-centered attributions and sense of competence) at Time 1 and parental solicitation at Time 3.

Mindful parenting and parenting cognitions influence each other over time. Parenting cognitions can affect parental solicitation via increases in mindful parenting. The discussion focuses on potential underlying processes.

Mindful parenting and parenting cognitions influence each other over time. Parenting cognitions can affect parental solicitation via increases in mindful parenting. The discussion focuses on potential underlying processes.Mendelian Randomization (MR) represents a class of instrumental variable methods using genetic variants. It has become popular in epidemiological studies to account for the unmeasured confounders when estimating the effect of exposure on outcome. The success of Mendelian Randomization depends on three critical assumptions, which are difficult to verify. Therefore, sensitivity analysis methods are needed for evaluating results and making plausible conclusions. We propose a general and easy to apply approach to conduct sensitivity analysis for Mendelian Randomization studies. Bound et al. (1995) derived a formula for the asymptotic bias of the instrumental variable estimator. Based on their work, we derive a new sensitivity analysis formula. The parameters in the formula include sensitivity parameters such as the correlation between instruments and unmeasured confounder, the direct effect of instruments on outcome and the strength of instruments. In our simulation studies, we examined our approach in various scenarios using either individual SNPs or unweighted allele score as instruments. By using a previously published dataset from researchers involving a bone mineral density study, we demonstrate that our proposed method is a useful tool for MR studies, and that investigators can combine their domain knowledge with our method to obtain bias-corrected results and make informed conclusions on the scientific plausibility of their findings.In many applications such as copy number variant (CNV) detection, the goal is to identify short segments on which the observations have different means or medians from the background. Those segments are usually short and hidden in a long sequence, and hence are very challenging to find. We study a super scalable short segment (4S) detection algorithm in this paper. This nonparametric method clusters the locations where the observations exceed a threshold for segment detection. It is computationally efficient and does not rely on Gaussian noise assumption. Moreover, we develop a framework to assign significance levels for detected segments. We demonstrate the advantages of our proposed method by theoretical, simulation, and real data studies.In clinical research, validated surrogate markers are highly desirable in study design, monitoring, and analysis, as they do not only reduce the required sample size and follow-up duration, but also facilitate scientific discoveries. However, challenges exist to identify a reliable marker. One particular statistical challenge arises on how to measure and rank the surrogacy of potential markers quantitatively. We review the main statistical methods for evaluating surrogate markers. In addition, we suggest a new measure, the so-called "population surrogacy fraction of treatment effect," or simply the p-measure, in the setting of clinical trials. The p-measure carries an appealing population impact interpretation and supplements the existing statistical measures of surrogacy by providing "absolute" information. We apply the new measure along with other prominent measures to the HIV Prevention Trial Network 052 Study, a landmark trial for HIV/AIDS treatment-as-prevention.Estimation of the proportion of living HIV infected persons that have been diagnosed is critical for tracking progress toward meeting the UNAIDS goal that all persons who need HIV treatment receive it. The objective of this article is to develop a method for estimating that proportion. The methodological problem is that persons with undiagnosed HIV infection are not directly observable and are a "hidden" population. Here we propose a methodology for estimating the proportion diagnosed that is relatively simple to implement. The key idea is that in many settings certain health conditions such as pregnancy or an upcoming surgery lead to mandatory HIV tests. The size of the undiagnosed infected population can be estimated from the numbers of infected persons diagnosed by mandatory tests and an estimate of the rate that persons in the undiagnosed infected population receive mandatory tests. We discuss approaches for estimating the rate of mandatory testing in the undiagnosed population, such as surgical or pregnancy rates.