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High performance photodetectors based on van der Waals heterostructures (vdWHs) are crucial to developing micro-nano-optoelectronic devices. However, reports show that it is difficult to balance fast response and high sensitivity. Doxorubicin In this work, we design a photovoltaic field-effect photodiode (PVFED) based on the WSe2/MoS2/WSe2 double vdWHs, where the photovoltage that originated from one vdWH modulates the optoelectronic characteristics of another vdWH. The proposed photodiode exhibits an excellent self-powered ability with a high responsivity of 715 mA·W-1 and fast response time of 45 μs. This work demonstrates an efficient method that optimizes the photoelectric performance of vdWH by introducing the photovoltaic field effect.The recently discovered capillary foams are aqueous foams stabilized by the synergistic action of colloidal particles and a small amount of oil. Characteristically, their gas bubbles are coated by a particle-stabilized layer of oil and embedded in a gel network of oil-bridged particles. This unique foam architecture offers opportunities for engineering new foam-related materials and processes, but the necessary understanding of its structure-property relations is still in its infancy. Here, we study the effects of particle wettability, particle volume fraction, and oil-to-particle ratio on the structure and selected properties of capillary foams and use our findings to relate measured foamability, foam stability, and rheological key parameters to the observed foam microstructure. We see that particle wettability not only determines the type of gel network formed but also influences the prevalence of oil droplets included within the foam. Our results further show that the stability and rheology of capillary foams are mainly a function of the particle volume fraction whereas the foamability and observed microstructure are sensitive also to the oil-to-particle ratio. These insights expand our fundamental understanding of capillary foams and will greatly facilitate future work on new foam formulations.Using simulations and theory, we examine the enthalpy and entropy of hydrophobic hydration which exhibit minima in supercooled water, contrasting with the monotonically increasing temperature dependence traditionally ascribed to these properties. The enthalpy/entropy minima are marked by a negative to positive sign change in the heat capacity at a size-dependent reversal temperature. A Gaussian fluctuation theory accurately captures the reversal temperature, tracing it to water's distinct thermal expansivity and compressibility influenced by its metastable liquid-liquid critical point.With the increasing knowledge about the important roles of gut microbiota on the biological system, a systematic strategy to profile the fecal metabolome is urgently needed. Thus, an unbiased, efficient, and reproducible fecal metabolite extraction protocol needs to be established; however, the effect of biphasic extraction methods for the fecal samples remains unclear. In this study, five different methods were assessed in the extraction of polar and non-polar metabolites for the liquid chromatography-mass spectrometry (LC-MS)-based mouse fecal metabolomic study. First, the detection coverage of two extraction systems, the Bligh and Dyer extraction method (M1, chloroform/methanol/water, 2/2/1.8) and Matyash method (M2, methyl tert-butyl ether (MTBE)/methanol/water, 10/3/2.5), was compared; then, MTBE/methanol/water system with different solvent ratios (M3, 2.6/2.0/2.4; M4, 4.5/1/2.5; and M5, 3/2.5/2.5) were further evaluated. The results showed that M2 showed higher detection coverage than M1. For the MTBE/methanol/water system with different solvent ratios, M3 showed the largest detection coverage based on peak numbers and numbers of putatively annotated metabolites, while M4 presented the least overlap between two phases, higher peak intensities of metabolites, and superior reproducibility. Based on the above evidence, M4 was recommended for the biphasic extraction of fecal metabolites in the LC-MS-based mouse fecal metabolomic study.Geometry effect and electronic effect are both essential for the rational design of a highly efficient electrocatalyst. In order to untangle the relationship between these effects and electrocatalytic activity, the perryite phase with a versatile chemical composition, (NixFe1-x)8(TyP1-y)3 (T = Si and Ge; 1 ≥ x, y ≥ 0), was selected as a platform to demonstrate the influence of geometry (e.g., atomic size and bond length) and electronic (e.g., bond strength and bonding scheme) factors toward the oxygen evolution reaction (OER). It was realized that the large Ge atom in the perryite phase can expand the unit cell parameters and interatomic distances (i.e., weaken bond strengths), which facilitates the phase transformation into active metal oxyhydroxide during OER. The quaternary perryite phase, Ni7FeGeP2, displays excellent OER activity and achieves current densities of 20 and 100 mA/cm2 at overpotentials of 239 and 273 mV, respectively. The oxidation state of Ni and Fe in the perryite phase before/after OER was analyzed and discussed. The result suggests that incorporating the Fe element in the system may increase the rate constant of OER (KOER) and therefore keeps the Ni element in a low valance state (i.e., Ni2+). This work indicates that the manipulation of geometry and electronic factors can promote phase transformation as well as OER activity, which exemplifies a strategy to design a promising "precatalyst" for OER.This study tested two sediment amendments with active sorbents injection of aluminum (Al) into sediments and thin-layer capping with Polonite (calcium-silicate), with and without the addition of activated carbon (AC), for their simultaneous sequestration of sediment phosphorus (P), hydrophobic organic contaminants (HOCs), and metals. Sediment cores were collected from a eutrophic and polluted brackish water bay in Sweden and incubated in the laboratory to measure sediment-to-water contaminant release and effects on biogeochemical processes. We used diffusive gradients in thin-film passive samplers for metals and semi-permeable membrane devices for the HOC polychlorinated biphenyls and polycyclic aromatic hydrocarbons. Al injection into anoxic sediments completely stopped the release of P and reduced the release of cadmium (Cd, -97%) and zinc (Zn, -95%) but increased the sediment fluxes of PAH (+49%), compared to the untreated sediment. Polonite mixed with AC reduced the release of P (-70%), Cd (-67%), and Zn (-89%) but increased methane (CH4) release. Adding AC to the Al or Polonite reduced the release of HOCs by 40% in both treatments. These results not only demonstrate the potential of innovative remediation techniques using composite sorbent amendments but also highlight the need to assess possible ecological side effects on, for example, sedimentary microbial processes.Increasing evidence indicates that the cancer stem cell (CSC) subpopulation contributes to the therapeutic resistance and metastasis of tumors, leading to patient recurrence and death. Herein, we designed and synthesized several compounds by conjugating lapatinib derivatives with different CSC inhibitors to treat with lapatinib-induced MDA-MB-231 drug-resistant cells. In vitro biological studies indicated that 3a showed strong cytotoxicity and EGFR enzyme inhibitory activity and effectively reversed lapatinib-mediated resistance of MDA-MB-231 cells via inhibiting triple-negative breast cancer (TNBC) cell stemness and the AKT/ERK signaling pathway. In addition, 3a was capable of strongly suppressing the invasion and migration of TNBC cells by inhibiting the Wnt/β-catenin signaling pathway and MMP-2 and MMP-9 protein expression. In vivo tumorigenicity tests showed that 3a could inhibit the occurrence of TNBC by inhibiting BCSCs, proving 3a is a potential EGFR and CSC dual inhibitor for TNBC treatment.Not available.Not available.Not available.HLA-DPB1 mismatches between donor and recipient are commonly seen in allogeneic hematopoietic stem cell transplantation (HSCT) from an unrelated donor. HLA-DPB1 mismatch, conventionally determined by the similarity of the T-cell epitope (TCE), is associated with an increased risk of acute graft-versus-host disease (aGVHD) and a decreased risk of disease relapse. We investigated the clinical impact of HLA-DPB1 molecular mismatch quantified by mismatched eplets (ME) and Predicted Indirectly Recognizable HLA Epitopes score (PS) in a cohort of 1,514 patients receiving HSCT from unrelated donors matched at HLA-A, -B, -C, -DRB1/3/4/5, and -DQB1 loci. HLA-DPB1 alloimmunity in the GVH direction determined by high GVH ME/PS was associated with a reduced risk of relapse (HR 0.83, P= .05 for ME) and increased risk of grade 2-4 aGVHD (HR 1.44, P less then .001 for ME), whereas high HVG ME/PS was only associated with an increased risk of grade 2-4 aGVHD (HR 1.26, P= .004 for ME). Notably, in the permissive mismatch subgroup classified by TCE grouping, high HVG ME/PS was associated with an increased risk of relapse (HR 1.36, P= .026 for ME) and grade 2-4 aGVHD (HR 1.43, P= .003 for PS-II). Decision curve analysis showed GVH ME outperformed other models and provided the best clinical net benefit for the modification of aGVHD prophylaxis regimen in patients with high risk of developing clinically significant aGVHD. In conclusion, molecular assessment of HLA-DPB1 mismatch enables separate prediction of HVG or GVH alloresponse quantitatively and allows further refinement of HLA-DPB1 permissiveness as defined by conventional TCE grouping.Not available.In order to explore the mechanism of gefitinib-acquired resistance in lung cancer, a new biomarker has been developed for early clinical diagnosis and intervention; human NSCLC (Non-Small Cell Lung Cancer) cell lines H292 (denoted as H292S) and PC9 (denoted as PC9S) were used to establish gefitinibresistant NSCLC cell lines H292 and PC9 models. CCK-8 (Cell Counting Kit-8) method was used to test the drug resistance of the cells. circRNAs (circular RNAs) that were differentially expressed before and after resistance were screened by RNA sequencing technology. The effects of circSETD3 overexpression and interference on the sensitivity of gefitinib was observed to analyze the nuclear localization of circSETD3 and verify the interaction between circSETD3-miR-520h-ABCG2. The results showed that the most significant change in differential expression of human NSCLC cell lines before and after drug resistance was hsa_circ_0000567, that is, circSETD3, which is mainly present in the cytoplasm. In H292S and PC9S, compared with the negative control group, the cell proliferation ability of the overexpression group was significantly increased, and the apoptosis ability was significantly decreased. In H292R and PC9R, compared with the negative control group, the proliferation ability of the interference group was significantly decreased, and the apoptosis ability was significantly increased. Overexpression of circSETD3 to H292S and PC9S, the expression of ABCG2 increased significantly. Also, the expression of ABCG2 decreased significantly after transfection with miR-520h mimics. H292R and PC9R interfered with circSETD3, the expression of ABCG2 decreased significantly. Moreover, the expression of ABCG2 increased significantly after transfection with miR-520h inhibitor. In conclusion, circSETD3 can be used as a novel biomarker for lung cancer. It relieves miR-520h degradation of the transporter ABCG2 by down-regulating the miR-520h expression, causing gefitinib to be pumped out of the cell.