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Forty-eight patients completed all assessment steps and were enrolled in the study. It has been shown that 27 patients did not have drug allergy. BLA hypersensitivity was proven in 21 patients by using in vivo test algorithm. More than half of the patients were diagnosed via skin tests with culprit drug. Conclusion Allergy work-up should be performed in patients with immediate reactions to BLA. A skin test can demonstrate BLA hypersensitivity in most patients. Thus, skin tests should be performed prior to the drug provocation test.Chloroquine and hydroxychloroquine are drugs that have shown in vitro activity on the replication of certain coronaviruses. In the context of the SARS-Cov-2 epidemic, the virus responsible for the novel coronavirus disease (COVID-19), these two drugs have been proposed as possible treatments. The results of the first clinical studies evaluating the effect of hydroxychloroquine do not support any efficacy of this drug in patients with COVID-19, due to major methodological weaknesses. Yet, these preliminary studies have aroused considerable media interest, raising fears of massive and uncontrolled use. In the absence of evidence of clinical benefits, the main risk is of exposing patients unnecessarily to the well-known adverse effects of hydroxychloroquine, with a possibly increased risk in the specific setting of COVID-19. In addition, widespread use outside of any recommendation risks compromising the completion of good quality clinical trials. The chloroquine hype, fueled by low-quality studies and media announcements, has yielded to the implementation of more than 150 studies worldwide. This represents a waste of resources and a loss of opportunity for other drugs to be properly evaluated. In the context of emergency, rigorous trials are more than ever needed in order to have, as soon as possible, reliable data on drugs that are possibly effective against the disease. Meanwhile, serious adverse drug reactions have been reported in patients with COVID-19 receiving hydroxychloroquine, justifying to limit its prescription, and to perform suitable cardiac and therapeutic drug monitoring.Objectives New methodological approaches, such as the umbrella review, constitute an important pathway for synthesizing the scientific evidence provided from studies with a high level of evidence. This study aims to summarize the results on the effectiveness of temporary anchorage devices (TADs) and the factors that contribute to their success or failure during orthodontic treatment in patients of different age groups and to identify the gaps in knowledge based on analysis of the scientific literature. Methods An umbrella review of systematic reviews and meta-analyses was performed. A quality evaluation and a descriptive analysis of the included studies were conducted. The study protocol was registered at the International Prospective Register of Systematic Reviews (PROSPERO CRD42018094463). Results Seventeen systematic reviews and meta-analyses were considered (10 descriptive and 7 with meta-analysis; 12 of high quality and 5 of moderate quality). Bafilomycin A1 research buy Variability was observed in the type of intervention and the type of system (TADs). Most of the studies reported high success rates (≥90%), and just one systematic review indicated a low rate of success (≤56%) for the mini-screws. All the studies discussed several factors related to the success of the TADs. These factors were classified as device-related factors, patient-related factors, procedure-related factors, and orthodontic treatment-related factors. Conceptual and methodological gaps were observed when considering the data analysis, the terminology used, and the orthodontic protocols. Conclusions The results should be analysed cautiously because of several research gaps related to the methodological quality and the high heterogeneity of the original studies and because of the necessity to add several clinical and sociodemographic variables to enrich the data analysis.Article title and bibliographic information Humanities in Predoctoral Dental Education A Scoping Review. Marti KC, Mylonas AI, MacEachern M, Gruppen L. J Dent Educ 2019;83(10)1174-1198. Source of funding None declared. Type of study/design A scoping review.Article title and bibliographic information Optimal number of implants for complete-arch implant-supported prostheses with a follow-up of at least 5 years A systematic review and meta-analysis. de Luna Gomes JM, et al. J Prosthet Dent 2019;121(5)766-774.e3. Source of funding Information not available. Type of study/design Systematic review with meta-analysis of data.Article title and bibliographic information Efficacy of Corticosteroids on Postoperative Endodontic Pain A Systemic Review and Meta-analysis. Shamszadeh S, Shirvani A, Eghbal MJ, Asgary S. J Endod 2018;44(7)1057-1065. Source of funding The authors' own institution, Shahid Beheshti University of Medical Sciences. Type of study/design Systematic review with meta-analysis of data.Article title and bibliographic information Root resorption in orthodontic treatment with clear aligners A systematic review and meta-analysis. Fang X, Qi R, Liu C. J Orthod Craniofacial Res 2019; Jul 19. doi 10.1111. Source of funding Natural Science Foundation of Guangdong Province, China. Type of study/design Systematic review-Meta-Analysis of Randomized Controlled Trials.Article title and bibliographic information Clinical performance of glass ionomer cement and composite resin in class II restorations in primary teeth A systematic review and meta-analysis. Dias AGA, Magno MB, Delbem ACB, Cunha RF, Maia LC, Pessan JP. J Dent 2018;731-13. Source of funding Information not available. Type of study/design Systematic review with meta-analysis of data.Article title and bibliographic information Long-term effects of functional appliances in treated versus untreated patients with class II malocclusion A systematic review and meta-analysis. Cacciatore G, Ugolini A, Sforza C, Gbinigle O, Plüddemann A. PLoS One 14e0221624. Source of funding Authors reported no specific funding for this research study. Type of study/design Systematic review with meta-analysis of data.Article title and bibliographic information Comparison of immediate implant placement in infected and noninfected extraction sockets systematic review and meta-analysis. Lee J, Park D, Koo K-T, Seol Y-J, Lee Y-M. Acta Odont Scand 2018;76(5)338-45. Source of funding This research did not receive any special grants from funding agencies in the public, commercial, or not-for-profit sectors. Type of study/design Systematic review and meta-analysis.Article title and bibliographic information Dental caries in South American Indigenous people A systematic review. Soares GH, Pereira NF, Gabriela M, Biazevic H, Braga MM, Michel-Crosato E. Community Dent Oral Epidemiol 2019;47(2)142-52. Source of funding Brazilian National Council for Scientific and Technological Development (CNPq). Type of study/design Systematic review with meta-analysis.Article title and bibliographic information Secondary alveolar bone grafting using autologous versus alloplastic material in the treatment of cleft lip and palate patients systematic review and meta-analysis. Scalzone A, Flores-Mir C, Carozza D, d'Apuzzo F, Grassia V, Perillo L. Prog Orthod 2019;20(6)1-10. Source of funding The authors received no financial support for this study. Type of study/design Systematic review and meta-analysis.Article title and bibliographic information Effect of cement type on the clinical performance and complications of zirconia and lithium disilicate tooth-supported crowns A systematic review. Report of the Committee on Research in Fixed Prosthodontics of the American Academy of Fixed Prosthodontics. Maroulakos G, Thompson GA, Kontogiorgos ED. J Prosthet Dent 2019;121754-65. Source of funding Unknown. Type of study/design Systematic review.Article title and bibliographic information Periodontal condition of patients with thalassemia major A systematic review and meta-analysis. Akcalı A, Yıldız MS, Akcalı Z, Huck O, Friedmann A. Arch Oral Biol 2019;102113-21. Source of funding Information is not available and the authors state that no specific funding was available for this study. Type of study/design Systematic review with meta-analysis of data.Article title and bibliographic information The effectiveness of Alt-RAMEC combined with maxillary protraction in the treatment of patients with a class III malocclusion a systematic review and meta-analysis, Mohammed Almuzian, Elise McConnell, M. Ali Darendeliler, Fahad Alharbi & Hisham Mohammed. J Orthod 2018;45(4);250-9. Source of funding No financial support was reported. Type of study/design Systematic review.Background It has been shown that the risk of developing oral cancer is closely related to the intensity and duration of exposure to alcohol and tobacco. Even so, the use of mouthwashes with alcohol in their compositions and the increased risk of oral cancer has been a source of controversy for decades. Objective This study proposes a systematic review and a meta-analysis of the literature, to assess the possible relationship between the use of mouthwashes with alcohol and the development of oral and pharyngeal cancers. Materials and methods A systematic search was done using the Medline and PubMed databases. Exclusion criteria were as follows articles published in languages other than English or Spanish, systematic reviews, and expert opinions. No limitations were used for publication date. Results A total of 14 articles were obtained, 11 case-control studies and 3 clinical trials. Three case-control studies found no statistically significant evidence between the relationship of mouthwash use and oral cancer and the remaining 8 case-control studies found statistically significant evidence. The 3 clinical trials observed a relationship between the use of mouthwashes with alcohol and the possibility of developing cancer due to the genotoxicity and mutagenic capacity of alcohol in chronic contact with oral tissues and mucous membranes. The meta-analysis resulted in an OR = 1.480 and a P-value = .161 (95% CI 0.855; P-value = 2.561) for the analysis of studies of cancer risk and consumption of mouthwashes with alcohol and OR = 1.057 0.364 (95% CI 0.951; P-value = 1.174) for studies that related the risk of cancer and mouthwash use without taking into account the presence of alcohol. Conclusions There is no sufficient evidence to accept the proposition that the use of mouthwashes containing alcohol can influence the development of oral cancer.Objective To evaluate if the topical application of 10% potassium nitrate applied before in-office bleaching is effective to reduce the risk and intensity of tooth sensitivity (TS), as well as to evaluate if its application can jeopardize color change. Materials and methods A randomized, split-mouth triple-blind clinical trial was conducted on 43 young patients with incisors A2 or darker. Half of the patient's upper arch received either the application of a 10% potassium nitrate or placebo gel for 10 min in a university setting. In-office bleaching was performed in three 15-min applications in two clinical sessions (1-week interval) using 35% hydrogen peroxide. Risk and intensity of TS was recorded with a 0-4 Numeric Rating Scale and a 0-10 Visual Analogue Scale during bleaching, 1 hour, 24 hours, and 48 hours after bleaching. Color was evaluated before and 1 month after bleaching with shade guides (Vita Classical and Vita Bleachedguide) and a spectrophotometer. The risk of TS (McNemar's test) and intensity of TS (Wilcoxon signed-rank for Numeric Rating Scale and paired t-test for Visual Analogue Scale) were statistically evaluated.