Ortegahedegaard3220

Among patients who received a lenalidomide-sparing regimen at 2L, this was most often a proteasome inhibitor-based regimen. Mortality rate was 26.1/100 person-years, and median (95% confidence interval) survival from 2L initiation was 32.4 (31.2-33.6) months. Survival differed by various factors, shorter survival was reported in the non-ASCT group, those receiving a lenalidomide-sparing regimen at 2L, older patients (≥ 70 years), and those with multiple comorbidities. This analysis provides insight into the real-world use of approved novel MM treatments and highlights an ongoing unmet need to improve outcomes, particularly for selected patient groups.

Horizontal instability is a common problem after acromioclavicular joint injuries. The aim of this study was to evaluate if there is a difference regarding horizontal stability between an anatomical and a non-anatomical configuration of the double tunnel coraco-clavicular ligament reconstruction of the acromioclavicular joint.

Thirteen acromioclavicular joints of human cadaveric shoulders in ethanol-glycerin fixation were included in the study and underwent cyclic anterior and posterior translational testing at a load of 70N using an electromechanical uniaxial testing machine. The shoulders were randomly assigned to the following groups double coraco-clavicular tunnel technique in an anatomical configuration (DCTa) and double coraco-clavicular tunnel technique in an inverse configuration of the anatomical position (DCTb). The dislocation was recorded with a 3D optical measuring system.

The total horizontal displacement (p

 = 0.0221; p

 = 0.082) was significantly higher for the non-anatomical reconstrunstruction should focus on an anatomically correct position of the suture devices.

It is currently unclear whether management and outcomes of critically ill patients differ between men and women. We sought to assess the influence of age, sex and diagnoses on the probability of intensive care provision in critically ill cardio- and neurovascular patients in a large nationwide cohort in Switzerland.

Retrospective analysis of 450,948 adult patients with neuro- and cardiovascular disease admitted to all hospitals in Switzerland between 01/2012 and 12/2016 using Bayesian modeling.

For all diagnoses and populations, median ages at admission were consistently higher for women than for men [75 (64;82) years in women vs. 68 (58;77) years in men, p < 0.001]. Overall, women had a lower likelihood to be admitted to an intensive care unit (ICU) than men, despite being more severely ill [odds ratio (OR) 0.78 (0.76-0.79)]. ICU admission probability was lowest in women aged > 65years (OR womenmen 0.94 (0.89-0.99), p < 0.001). Women < 45years had a similar ICU admission probability as men limited data available from the registries, our findings suggest that current ICU triage algorithms could benefit from careful reassessment. Further, and ideally prospective, studies are needed to confirm our findings.

A biallelic intronic AAGGG repeat expansion in the Replication Factor C subunit 1 (RFC1) gene has been recently associated with Cerebellar Ataxia, Neuropathy, Vestibular Areflexia Syndrome, a disorder often presenting as a slowly evolving sensory neuropathy at the onset. gp91ds-tat clinical trial "Chronic Idiopathic Axonal Polyneuropathy" (CIAP) is a common indolent axonal neuropathy of adulthood which remains without an identifiable cause despite thorough investigations.

We screened 234 probands diagnosed with CIAP for a pathogenic biallelic RFC1 AAGGG repeat expansion. Patients were selected from 594 consecutive patients with neuropathy referred to our tertiary-care center for a sural nerve biopsy over 10years.

The RFC1 AAGGG repeat expansion was common in patients with pure sensory neuropathy (21/40, 53%) and less frequent in cases with predominantly sensory (10/56, 18%, P < 0.001) or sensorimotor (3/138, 2%, P < 0.001) neuropathy. The mutation was associated with sensory ataxia (τ

 = 0.254, P < 0.001), autonomic disturbances (35% vs 8%, Prevalence Odds Ratio-POR 6.73 CI 95% 2.79-16.2, P < 0.001), retained deep tendon reflexes (score 18.0/24 vs 11.5/24, R = 0.275, P < 0.001). On pathology, we observed absent/scant regenerative changes (τ

 = -0.362, P < 0.001), concomitant involvement of large (100% and 99%, n.s.), small myelinated (97% vs 81%, POR 7.74 CI 95% 1.03-58.4, P = 0.02) and unmyelinated nerve fibers (85% vs 41%, POR 8.52 CI 95% 3.17-22.9, P < 0.001). Cerebellar or vestibular involvement was similarly rare in the two groups.

This study highlights the frequent occurrence of the RFC1 AAGGG repeat expansion in patients diagnosed with CIAP and characterizes the clinical and pathological features of the related neuro(no)pathy.

This study highlights the frequent occurrence of the RFC1 AAGGG repeat expansion in patients diagnosed with CIAP and characterizes the clinical and pathological features of the related neuro(no)pathy.Considering the similarities with other pandemics due to respiratory virus infections and subsequent development of neurological disorders (e.g. encephalitis lethargica after the 1918 influenza), there is growing concern about a possible new wave of neurological complications following the worldwide spread of SARS-CoV-2. However, data on COVID-19-related encephalitis and movement disorders are still limited. Herein, we describe the clinical and neuroimaging (FDG-PET/CT, MRI and DaT-SPECT) findings of two patients with COVID-19-related encephalopathy who developed prominent parkinsonism. None of the patients had previous history of parkinsonian signs/symptoms, and none had prodromal features of Parkinson's disease (hyposmia or RBD). Both developed a rapidly progressive form of atypical parkinsonism along with distinctive features suggestive of encephalitis. A possible immune-mediated etiology was suggested in Patient 2 by the presence of CSF-restricted oligoclonal bands, but none of the patients responded favorably to immunotherapy. Interestingly, FDG-PET/CT findings were similar in both cases and reminiscent of those observed in post-encephalitic parkinsonism, with cortical hypo-metabolism associated with hyper-metabolism in the brainstem, mesial temporal lobes, and basal ganglia. Patient's FDG-PET/CT findings were validated by performing a Statistical Parametric Mapping analysis and comparing the results with a cohort of healthy controls (n = 48). Cerebrum cortical thickness map was obtained in Patient 1 from MRI examinations to evaluate the structural correlates of the metabolic alterations detected with FDG-PET/CT. Hypermetabolic areas correlated with brain regions showing increased cortical thickness, suggesting their involvement during the inflammatory process. Overall, these observations suggest that SARS-CoV-2 infection may trigger an encephalitis with prominent parkinsonism and distinctive brain metabolic alterations.

Emergency laparotomy is a considerable component of a colorectal surgeon's workload and conveys substantial morbidity and mortality, particularly in older patients. Frailty is associated with poorer surgical outcomes. Frailty and sarcopenia assessment using Computed Tomography (CT) calculation of psoas major area predicts outcomes in elective and emergency surgery. Current risk predictors do not incorporate frailty metrics. We investigated whether sarcopenia measurement enhanced mortality prediction in over-65s who underwent emergency laparotomy and emergency colorectal resection.

An analysis of data collected prospectively during the National Emergency Laparotomy Audit (NELA) was conducted. Psoas major (PM) cross-sectional area was measured at the L3 level and a ratio of PM to L3 vertebral body area (PML3) was calculated. Outcome measures included inpatient, 30-day and 90-day mortality. Statistical analysis was conducted using Mann-Whitney, Chi-squared and receiver operating characteristics (ROC). Logist appears to improve mortality risk prediction.

PML3 is an accurate predictor of mortality in over-65 s undergoing emergency laparotomy. Addition of PML3 to POSSUM appears to improve mortality risk prediction.This study analysed the temperature and humidity properties of urban soils in the territory of the Mikhailovskaya Embankment Park of Culture and Recreation in Novosibirsk, Russian Federation, in the cold period of the 2018-2019 hydrological year. Data on the temperature of the air and soil at various depths, winter and spring soil moisture and data on the dynamics of snow accumulation and snow distribution were analysed. This study found that, despite high levels of humidity in the autumn and the high snow reserves that accumulated during the winter, a decrease in soil moisture content was observed after the snow had melted. Temperatures in the range of -3 to -7 °С were recorded in the layer of soil from 0 to 30 cm below the ground surface. Systematic clearing of the pedestrian zones of the park of snow during the winter leads to both an increase in snow height and, accordingly, water reserves in the snow in adjacent areas, and to exposure of the surfaces of rabattes, or cement subterranean garden beds, in which perennial ornamental plants are grown. This study also revealed the presence of an additional cooling effect within these rabattes on the temperature regime of the soils within them during the cold period.The concept of yield gaps provides a basis for identifying the main sources of production losses, caused by water or management deficiencies, which may help foresters and forest companies to better plan and make decisions in their areas. Thus, the aim of this study was to identify the magnitude and the major causes of yield gaps of eucalypts, being this the most planted forest genus in Brazil, in different producing regions of the state of Minas Gerais that has the largest planted area. To these ends, potential (Yp) and attainable (Ya) yields were simulated using the agroecological zone model (AEZ-FAO) adapted and calibrated for Brazilian eucalypt clones. Actual yield (Yr) data were obtained from 22 sites located in the state of Minas Gerais from 2009 to 2016, considering an average forest rotation of 6.7 years and plantings occurring between 2002 and 2010. From this, the total yield gap (YGtot), yield gap by water deficit (YGwd), and yield gap by sub-optimal management (YGman) were determined. The YGwd ranged from 37 to 69 m3 ha-1 year-1 across the 22 sites assessed, with an average value of 55 m3 ha-1 year-1. On the other hand, the YGman ranged from zero (optimal management) to 31 m3 ha-1 year-1. The eucalypt yield gap in commercial areas of Minas Gerais state was mainly caused by water deficit, which represented 77% of the total yield gap. On the other hand, the deficiencies in forest management accounted for 23% of the total yield gap.Personal protective clothing (PPC) is critical for worker safety and wellbeing from both protection and thermal management perspectives, particularly as PPC typically covers more than 90% of the body. Research of PPC in low-risk categories such as mining, oil, gas, and construction and their thermal management attributes is limited, although these industries represent a significant proportion of the industrial workforce, work across a broad range of major industries, and frequently work in hot and/or humid thermal environments. This study evaluated and characterized the thermal management attributes of a selection of commercial low-level risk PPC ensembles currently used around the world as well as a civilian/corporate wear ensemble, using a sweating thermal manikin. The results demonstrate that there are substantially poorer thermal attributes for the PPC ensembles. Predicted Heat Strain Index (PHS) results for hot conditions reveal significantly lower duration limited exposure (DLE) and considerably greater body water loss for the wearers of PPC.