Kristoffersennorup9610
Our results suggest that genetic diversification occurs in an ecological relevant setting on plant roots and proves to be a stable strategy for root colonization.Ischemic events related to carotid disease are far more strongly associated with plaque instability than stenosis. 3D high-resolution diffusion-weighted (DW) imaging can provide quantitative diffusion measurements on carotid atherosclerosis and may improve detection of vulnerable intraplaque hemorrhage (IPH). The 3D DW-stack of stars (SOS) sequence was implemented with 3D SOS acquisition combined with DW preparation. After simulation of signals created from 3D DW-SOS, phantom studies were performed. Three healthy subjects and 20 patients with carotid disease were recruited. Apparent diffusion coefficient (ADC) values were statistically analyzed on three subgroups by using a two-group comparison Wilcoxon-Mann-Whitney U test with p values less than 0.05 symptomatic versus asymptomatic; IPH-positive versus IPH-negative; and IPH-positive symptomatic versus asymptomatic plaques to determine the relationship with plaque vulnerability. ADC values calculated by 3D DW-SOS provided values similar to those calculated from other techniques. Mean ADC of symptomatic plaque was significantly lower than asymptomatic plaque (0.68 ± 0.18 vs. 0.98 ± 0.16 x 10-3 mm2 /s, p less then 0.001). ADC was also significantly lower in IPH-positive versus IPH-negative plaque (0.68 ± 0.13 vs. 1.04 ± 0.11 x 10-3 mm2 /s, p less then 0.001). Additionally, ADC was significantly lower in symptomatic versus asymptomatic IPH-positive plaque (0.57 ± 0.09 vs. 0.75 ± 0.11 x 10-3 mm2 /s, p less then 0.001). Our results provide strong evidence that ADC measurements from 3D DW-SOS correlate with the symptomatic status of extracranial internal carotid artery plaque. Further, ADC improved discrimination of symptomatic plaque in IPH. These data suggest that diffusion characteristics may improve detection of destabilized plaque leading to elevated stroke risk.
Early shaming experiences have been suggested to be associated with later psychopathological symptoms. Understanding this relationship is complex, due to a number of psychological processes potentially influencing this. Therefore, the aim of the current study was to further explore the nature of the mediating effect of experiential avoidance in the association between early shame experiences and psychological distress, and whether self-compassion moderates this relationship by mitigating the effects of this.
A cross-sectional design was conducted using self-report measures of early shaming experiences, experiential avoidance, self-compassion, and psychological distress.
An online study of 556 participants, comprised of participants from the general population and university students participated within this online study.
The moderated mediation model explained 51% of variance within depressive symptoms. Experiential avoidance was found to mediate the association between early shaming experiences and dptoms. Self-compassion-based interventions that target experiential avoidance may offer greater reductions within depressive symptoms.
Early shaming experiences have been linked to later psychological distress. Experiential avoidance identified a core underlying psychological process in the relationship between early shaming experiences and psychological distress. Self-compassion offers a range of protective features that may alleviate the effects of experiential avoidance and depressive symptoms. Self-compassion-based interventions that target experiential avoidance may offer greater reductions within depressive symptoms.This study aimed to investigate the effects of Marigold flower powder (MFP) and marigold flower extract (MFEx) as feed additives on the performance, blood parameters, antioxidant capacity, immunological parameters, microbial content, digestive enzymes and digestibility in growing Japanese quail. A total number of 350 birds randomly distributed into seven groups, with five replicates of 10 birds each, control diet (control group), the second, third and fourth groups were fed on a basal diet within MFP 0.6%, 0.9% and 1.2% respectively. Fifth, sixth and seventh groups received the basal diet plus MFEx 150, 200 and 250 ppm respectively. Quails fed on a diet supplemented with MFEx 200 ppm had significantly higher lipase levels (p ≤ 0.001) compared to the control and MFP 0.6% without any significant difference with other experimental groups. Moreover, all digestibility coefficients (DC) of nutrients except for nitrogen-free extract were significantly (p ≤ 0.001) affected by all dietary treatments. Quails fed on the diet supplemented with MFEx 200 ppm significantly (p ≤ 0.001) presented the best body weight, body weight gain, feed conversion ratio and the lowest feed intake over all groups. Total lipid profile, kidney functions and liver functions were significantly affected by both MFP and MFEx diets. The group treated with MFEx 250 ppm had lowest E. FX11 mouse coli and Salmonella population and the highest Lactobacilli population number. Antioxidant parameters and immune response (except for lymphocytes) were significantly affected (p ≤ 0.001) by different levels of MFP and MFEx. In conclusion, the addition of MFEx and MFP at 200 ppm followed by 250 ppm and 1.2% MFP, respectively, to the basal diet improved product productive performance, blood parameters, antioxidant capacity, immunological parameters, microbial content and digestibility in growing Japanese quail.Mfn2 is a mitochondrial fusion protein with bioenergetic functions implicated in the pathophysiology of neuronal and metabolic disorders. Understanding the bioenergetic mechanism of Mfn2 may aid in designing therapeutic approaches for these disorders. Here we show using endoplasmic reticulum (ER) or mitochondria-targeted Mfn2 that Mfn2 stimulation of the mitochondrial metabolism requires its localization in the ER, which is independent of its fusion function. ER-located Mfn2 interacts with mitochondrial Mfn1/2 to tether the ER and mitochondria together, allowing Ca2+ transfer from the ER to mitochondria to enhance mitochondrial bioenergetics. The physiological relevance of these findings is shown during neurite outgrowth, when there is an increase in Mfn2-dependent ER-mitochondria contact that is necessary for correct neuronal arbor growth. Reduced neuritic growth in Mfn2 KO neurons is recovered by the expression of ER-targeted Mfn2 or an artificial ER-mitochondria tether, indicating that manipulation of ER-mitochondria contacts could be used to treat pathologic conditions involving Mfn2.