Lykkefrench2303
The improved performance of semi-supervised learning increased the quality of the synthetic data produced in comparison to the baseline method. We achieved more accurate breast mass classification results (accuracy 90.41%, sensitivity 87.94%, specificity 85.86%) with our synthetic data augmentation compared to other state-of-the-art methods.
The proposed radiomics model has demonstrated a promising potential to synthesize and classify breast masses on ultrasound in a semi-supervised manner.
The proposed radiomics model has demonstrated a promising potential to synthesize and classify breast masses on ultrasound in a semi-supervised manner.
During capsulotomy, the force applied to the anterior capsule is a crucial parameter controlling capsule tears, that affects the clinical performance. This study aims to investigate the tear force in capsulotomy and analyze the effects of different tearing conditions on the tear force.
A three-dimensional model of the human lens was constructed based on published clinical data using the finite element (FE) method. The lens model consisted of four layers the anterior and posterior lens capsule, the cortex, and the nucleus. Distortion energy failure criterion combined with the bilinear interface law was used to express the crack propagation process at the edge of the anterior lens capsule. At the clamping position, a local coordinate system was established to parameterize the capsule tearing. The simulation results were then validated by conducting a capsulorhexis experiment using isolated porcine eyes with force-sensing forceps.
The simulation results showed a good agreement with the experimental data of two porcine specimens (No. PFK15 mw 6 and 9) during a stable tearing process (p-values=0.76 and 0.10). The mean force differences between the experimental data and the simulation were 3.10 ± 2.24 mN and 2.14 ± 1.73 mN, respectively. The tear direction with a minimum mean tear force was at θ
=0° and θ
=30°. The tear velocity was not significantly different to the variation in the tear force. However, an appropriate capsulorhexis diameter was found to contribute to the reduction of tear force.
The outcome of this paper demonstrates that our FE model could be used in modeling lens capsule tearing and the theoretical study of tear mechanism.
The outcome of this paper demonstrates that our FE model could be used in modeling lens capsule tearing and the theoretical study of tear mechanism.
The fracture of the astragalus is an unusual bone fracture (Ladero and Concejero, 2004) and is even more unusual in pediatric patients. The astragalus is a bone surrounded by cartilage and other structures making it difficult to appreciate on an X-ray which can lead to misdiagnosis (Ladero and Concejero, 2004; Inal and Inal, 2014) and could lead to not applying the right treatment and risk avascular necrosis or other sequelae.
3-year-old male with foot pain and edema+++, unable to walk or stand up since a fall 2 days before, had a doubtful diagnosis after an x-ray showed no apparent bone injury. A CT scan confirmed astragulus fracture; it was then treated adequately, thus avoiding complications that could have occurred had the fracture not been diagnosed and treated correctly.
The limb was immobilized with a suropodalic cast for 5 weeks. No surgery was performed because of the patient's age and because the fracture was not displaced (Hawkins type 1) (Jasqui-Remba and Rodriguez-Corlay, 2016; Urrutia et al., 1999).
There is a risk of misdiagnosis in these cases since the astragulus fracture might not show up in an X-ray, as in the case presented. A CT scan can detect the fracture and thus help consolidate the bone correctly. The correct differential diagnosis also reduces the risk of avascular necrosis, which increases due to poor blood supply to the astragalus.
There is a risk of misdiagnosis in these cases since the astragulus fracture might not show up in an X-ray, as in the case presented. A CT scan can detect the fracture and thus help consolidate the bone correctly. The correct differential diagnosis also reduces the risk of avascular necrosis, which increases due to poor blood supply to the astragalus.Mayer Rokitansky Kuster Hauser (MRKH) syndrome is a congenital disorder involving reproductive, genitourinary, bone, and cardiac malformation. The incidence is 1 in 4000-5000 females livebirths. The phenotype is female 46 XX karyotype, normal secondary sexual characteristics, and normal functional ovaries. The occurrence of leiomyoma in uterine remnant in MRKH syndrome is a very rare case, even though several cases have been reported. The diagnosis and management approach, in this case, is quite challenging. Here, we report a 38 years old female who represents multiple leiomyomas on the rudimentary uterus, then we did laparoscopic removal of the fibroids and adjacent rudimentary uterus.
Inguinal hernia is one of the most common surgical problems, often posing technical challenges even to expert surgeons. Amyand's hernia (AH) is an inguinal hernia whose sac contains the vermiform appendix. Primary appendiceal neoplasms are rare. We report the case of an appendiceal adenocarcinoma within an Amyand's hernia, presenting as an incarcerated right inguinal hernia.
A 87-year-old male presented in the emergency department due to a persistent right inguinal pain. Clinical examination revealed a tender right groin mass. Under the diagnosis of an right inguinal hernia, an operation was taken. Intraoperatively, an inflamed appendix and a part of the cecum were found in the hernia sac. The operation was completed with an ileocecal resection and a modified Bassini hernia repair. Histological examination revealed a adenocarcinoma of the appendix.
Amyand's hernia is an inguinal hernia that contains vermiform appendix in its sac. It consists 1% of all inguinal hernias while appendicitis in an Amyand's hernia accounts for 0.1% of all appendicitis cases. Adenocarcinomas of the appendix are even rarer, accounting for 0.2% to 0.5% of all intestinal malignancies, and 4%-6% of primary appendiceal neoplasms. Diagnosis is usually established intraoperatively.
A malignancy of the appendix should always be in the differential diagnosis of a right inguinal mass, in order to provide optimum surgical treatment.
A malignancy of the appendix should always be in the differential diagnosis of a right inguinal mass, in order to provide optimum surgical treatment.
Neoadjuvant imatinib for large GISTs may prevent tumor rupture and the need for extended surgery by reducing tumor size. In this study, we present a case of large gastric GIST with diaphragm invasion, due to the patient receiving laparoscopic resection following preoperative imatinib treatment.
A 72-year-old woman was hospitalized with left hypochondriac pain for a month. Examinations revealed a large heterogeneous gastric mass measuring 80 mm in size, arising from the greater curvature of the corpus. The mass invaded the left thoracic diaphragm. Treatment with imatinib at an initial dosage of 400 mg/day was initiated. After a further two months of follow-up, the lesion had sustained reduction to 50 mm in size, however, the invasion to the diaphragm remained. The patient eventually underwent laparoscopic partial gastrectomy and partial resection of the diaphragm with curative intent. Adjuvant chemotherapy was initiated at one month after the surgery, however, was discontinued due to nausea. After one-year follow-up, no recurrence was noted.
Neoadjuvant imatinib may shrink tumor size remarkably and prevent tumor rupture during surgery, and thus lead to increased rates of complete resection. To date, several publications have directly compared the oncologic results between laparoscopic and open resection for GISTs. In the present case, the tumor was movable, and moderately fixed on diaphragm. It was favorable condition for laparoscopic surgery.
This is the first report of a large gastric GIST invading the diaphragm that was successfully treated by laparoscopic resection after tumor reduction by neoadjuvant imatinib.
This is the first report of a large gastric GIST invading the diaphragm that was successfully treated by laparoscopic resection after tumor reduction by neoadjuvant imatinib.Numerous epidemiological studies have demonstrated that chronic PM2.5 exposure was associated with the lung carcinogenesis without known potential mechanisms. Exosomes-derived non-coding RNAs, including miRNAs, are proposed to play critical role in the occurrence and development of malignant diseases. So identification of exosomes-derived miRNAs could help us to better understand the molecular toxicity of PM2.5-induced lung cancer. Establishment chronic exposure animal and cell model with PM2.5 was conducted as before. HE staining was used for estimating the histological alternations of lungs in vivo. The expressions of EMT markers in vivo and vitro were quantified by Western blot. Then the exosomes in cell culture supernatant were extracted and the involved miRNAs were extracted and sequenced. The different expression level of miRNAs were verified by RT-PCR. Chronic PM2.5 exposure induced bronchial epithelial cell atypical hyperplasia and massive macrophage infiltration. PM2.5 exposure induce EMT event in viexosome-miRNAs may play role in the development of lung cancer induced by chronic PM2.5 exposure.Phosphorylation of RNA polymerase II (RNAP II) coordinates the temporal progression of eukaryotic transcription. The development and application of chemical genetic methods have enhanced our ability to investigate the intricate and intertwined pathways regulated by the kinases and phosphatases targeting RNAP II to ensure transcription accuracy and efficiency. Although identifying small molecules that modulate these enzymes has been challenging due to their highly conserved structures, powerful new chemical biology strategies such as targeted covalent inhibitors and small molecule degraders have significantly improved chemical probe specificity. The recent success in discovering phosphatase holoenzyme activators and inhibitors, which demonstrates the feasibility of selective targeting of individual phosphatase complexes, opens up new avenues into the study of transcription. Herein, we summarize how chemical biology is used to delineate kinases' identities involved in RNAP II regulation and new concepts in inhibitor/activator design implemented for kinases/phosphatases involved in modulating RNAP II-mediated transcription.Immersive virtual reality (VR) has been identified as a potentially revolutionary tool for psychological interventions. This study reviews current advances in immersive VR-based therapies for mental disorders. VR has the potential to make psychiatric treatments better and more cost-effective and to make them available to a larger group of patients. However, this may require a new generation of VR therapeutic techniques that use the full potential of VR, such as embodiment, and self-led interventions. VR-based interventions are promising, but further well-designed studies are needed that use novel techniques and investigate efficacy, efficiency, and cost-effectiveness of VR interventions compared with current treatments. This will be crucial for implementation and dissemination of VR in regular clinical practice.
