Fundernorton1642

Our approach results in more seamless reconstruction of the virtual WSIs. We validate our method quantitatively by comparing the virtually generated images to their corresponding consecutive real stained images.We compare our results to state-of-the-art unsupervised style transfer methods and to the measures obtained from consecutive real stained tissue slide images. We demonstrate our hypothesis about the effect of the PEC loss by comparing model robustness to color, contrast and brightness perturbations and visualizing bottleneck embeddings. We validate the robustness of the bottleneck feature maps by measuring their sensitivity to the different perturbations and using them in a tumor segmentation task. Additionally, we propose a preliminary validation of the virtual staining application by comparing interpretation of 2 pathologists on real and virtual tiles and inter-pathologist agreement.In this article, a new concept of convex-combined multiple neural networks (NNs) structure is proposed. This new approach uses the collective information from multiple NNs to train the model. Based on both theoretical and experimental analyses, the new approach is shown to achieve faster training convergence with a similar or even better test accuracy than a conventional NN structure. Two experiments are conducted to demonstrate the performance of our new structure the first one is a semantic frame parsing task for spoken language understanding (SLU) on the Airline Travel Information System (ATIS) data set and the other is a handwritten digit recognition task on the Mixed National Institute of Standards and Technology (MNIST) data set. We test this new structure using both the recurrent NN and convolutional NNs through these two tasks. The results of both experiments demonstrate a 4x-8x faster training speed with better or similar performance by using this new concept.Single nucleotide variant (SNV) plays an important role in cellular proliferation and tumorigenesis in various types of human cancer. Next-generation sequencing (NGS) has provided high-throughput data at an unprecedented resolution to predict SNVs. Currently, there exist many computational methods for either germline or somatic SNV discovery from NGS data, but very few of them are versatile enough to adapt to any situations. In the absence of matched normal samples, the prediction of somatic SNVs from single-tumor samples becomes considerably challenging, especially when the tumor purity is unknown. Here, we propose a new approach, STIC, to predict somatic SNVs and estimate tumor purity from NGS data without matched normal samples. The main features of STIC include (1) extracting a set of SNV-relevant features on each site and training the BP neural network algorithm on the features to predict SNVs; (2) creating an iterative process to distinguish somatic SNVs from germline ones by disturbing allele frequency; and (3) establishing a reasonable relationship between tumor purity and allele frequencies of somatic SNVs to accurately estimate the purity. We quantitatively evaluate the performance of STIC on both simulation and real sequencing datasets, the results of which indicate that STIC outperforms competing methods.Non-negative matrix factorization (NMF) is a dimensionality reduction technique based on high-dimensional mapping. It can effectively learn part-based representations. In this paper, we propose a method called Dual Hyper-graph Regularized Supervised Non-negative Matrix Factorization (HSNMF). To encode the geometric information of the data, the hyper-graph is introduced into the model as a regularization term. The advantage of hyper-graph learning is to find higher order data relationship to enhance data relevance. This method constructs the data hyper-graph and the feature hyper-graph to find the data manifold and the feature manifold simultaneously. The application of hyper-graph theory in cancer datasets can effectively find pathogenic genes. Microbiology inhibitor The discrimination information is further introduced into the objective function to obtain more information about the data. Supervised learning with label information greatly improves the classification effect. Furthermore, the real datasets of cancer usually contain sparse noise, so the -norm is applied to enhance the robustness of HSNMF algorithm. Experiments under The Cancer Genome Atlas (TCGA) datasets verify the feasibility of the HSNMF method.Detection and diagnosis of cancer are especially essential for early prevention and effective treatments. Many studies have been proposed to tackle the subtype diagnosis problems with those data, which often suffer from low diagnostic ability and bad generalization. This paper studies a multiobjective PSO-based hybrid algorithm (MOPSOHA) to optimize four objectives including the number of features, the accuracy, and two entropy-based measures the relevance and the redundancy simultaneously, diagnosing the cancer data with high classification power and robustness. First, we propose a novel binary encoding strategy to choose informative gene subsets to optimize those objective functions. Second, a mutation operator is designed to enhance the exploration capability of the swarm. Finally, a local search method based on the best/1 mutation operator of differential evolutionary algorithm (DE) is employed to exploit the neighborhood area with sparse high-quality solutions since the base vector always approaches to some good promising areas. In order to demonstrate the effectiveness of MOPSOHA, it is tested on 41 cancer datasets including thirty-five cancer gene expression datasets and six independent disease datasets. Compared MOPSOHA with other state-of-the-art algorithms, the performance of MOPSOHA is superior to other algorithms in most of the benchmark datasets.Brain functional connectivity (FC) has shown great potential in becoming biomarkers of brain status. However, the problem of accurately estimating FC from complex-noisy fMRI time series remains unsolved. Usually, a regularization function is more appropriate in fitting the real inherent properties of the brain function activity pattern, which can further limit noise interference to improve the accuracy of the estimated result. Recently, the neuroscientists widely suggested that the inherent brain function activity pattern indicates sparse, modular and overlapping topology. However, previous studies have never considered this factual characteristic. Thus, we propose a novel method by the integration of these inherent brain function activity pattern priors to estimate FC. Extensive experiments on synthetic data demonstrate that our method can more accurately estimate the FC than previous. Then, we applied the estimated FC to predict the symptom severity of depressed patients, the symptom severity is related to subtle abnormal changes in the brain function activity, a more accurate FC can more effectively capture the subtle abnormal brain function activity changes. As results, our method better than others with a higher correlation coefficient of 0.4201. Moreover, the overlapping probabilistic of each brain region can be further explored by the proposed method.Biological long short-term memory (B-LSTM) can effectively help human process all kinds of received information. In this work, a memristive B-LSTM circuit which mimics a conversion from short-term memory to long-term memory is proposed. That is, the stronger the signal, the more profound the memory and the higher the output. On this basis, an image binarization circuit using adaptive row threshold algorithm is proposed. It can make the image remain a deep impression on the strong pixel information and effectively filter the relatively weak pixel information. In combination with the function of image binarization, a memristive circuit for eyes state detection is proposed by adding corresponding horizontal projection calculation, subtraction calculation and judgement open or closed eyes modules. The proposed circuit can detect whether there is a blink between two adjacent facial images, which uses the characteristics of memristor to detect the difference of horizontal projection between two images. Due to the use of memristor, the proposed circuit can realize in-memory computing, which fundamentally avoids the problem of storage wall and shorten the execution time. Finally, an expectation application in fatigue driving based on the proposed method is demonstrated, which indicates the practicability of the circuit design in this work.In the last few years, accumulating evidences had demonstrated that long non-coding RNAs (lncRNAs) participated in the regulation of target gene expression and played an important role in biological processes and human disease development. Thus, prediction of the associations between lncRNAs and disease had become a hot research in the fields of human sophisticated diseases. Most of these methods considered the information of two networks (lncRNA, disease) while neglected other networks. In this study, we designed a multi-layer network by integrating the similarity networks of lncRNAs, diseases and genes, and the known association networks of lncRNA-disease, lncRNAs-gene, and disease-gene, and then we developed a model called MHRWR for predicting the lncRNA-disease potential associations based on random walk with restart. The performance of MHRWR was evaluated by experimentally verified lncRNA-disease associations based on leave-one-out cross validation. MHRWR obtained a reliable AUC value of 0.91344, which significantly outperformed some previous methods. To further validate the reproducibility of performance, we used the model of MHRWR to verify related lncRNAs of colon cancer, colorectal cancer and lung adenocarcinoma in the case studies. The codes of MHRWR is available on https//github.com/yangyq505/MHRWR.Interpretation of high level cognitive behavior of human brain requires comprehensive understanding of spike transfer process at neuronal level. Synapses play major role in spike transfer process from one neuron to another. An expanded leaky integrate and fire model of a neuron in multiple input and single output configuration with threshold variability for spike transfer process is proposed in this paper. Asynchronous generation of post synaptic potential is considered. Multiple types of excitatory and inhibitory post-synaptic potentials are also included in the model. An analytical expression of membrane potential including threshold variability and activity dependant noise process has been developed. The model captures several important features of a spiking neuron through a set of well defined parameters. Simulation results are provided to explain various aspects of the proposed model. A functionally scaled version of the model has also been compared with limited experimental data, available from the Allen Institute of Brain Science.Postural sway is a product of the neuromuscular system that is commonly used in contemporary labs and clinics for the assessment of postural stability. In this study, we analyzed the transient responses of the neuromuscular system during the rise-on-toes (ROT) movement in eighteen 11 yrs old girls. Their center of pressure (COP) trajectories were recorded with standard force-platform during the transition from quiet stance to standing on toes. To assess the robustness of children's postural stability, we compared the ROT trajectories while the movement was performed with and without vision. Our results confirmed that the dynamic characteristics of the COP step response were significantly modified by visual feedback. In particular, the ROT test performed with eyes closed (EC) was characterized by a four-fold increase of COP chaotic oscillations at the target (tiptoe) position. This resulted in a substantial increase in the movement's index of difficulty (ID) thus to achieve adequate accuracy of the target-oriented movement the COP velocity was decreased accordingly.