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dult children, should be included in treatment programs.

Individualized plans for healthy behaviors should take into consideration patients' readiness for adopting stage-tailored strategies of helping relationships of significant others to adhere to the health-promoting lifestyle. To promote a healthier lifestyle, significant others, such as spouses and adult children, should be included in treatment programs.

The organizational structure of maternity services determines the choice of which professionals provide care during pregnancy, birth, and the postnatal period, and it influences the kind of care they deliver and the level of continuity of care offered. There is considerable evidence that demonstrates a relationship between how care is provided and the maternal and neonatal health outcomes. Registered midwives and obstetricians provide maternity care across Spain. To date, no studies have assessed whether maternity outcomes differ between these two groups.

The aim of this study was to examine the association between the care received (midwifery care versus obstetric care) and the maternal and neonatal outcomes in women with normal, low- and medium-risk pregnancies in Spain from 2016 to 2019.

A prospective, multicentre, cross-sectional study was carried out as part of COST Action IS1405 at 44 public hospitals in Spain in the years 2016-2019. The protocol can be accessed through the registry ISRCTN14062994 of operative births and severe perineal damage and had no higher adverse outcomes. No statistically significant differences were observed in the use of other obstetric interventions between the two groups.

The findings of this study should encourage a shift in the current maternity care system towards a greater integration of midwifery-led services in order to achieve optimal birth outcomes for women and newborns.

ISRCTN14062994.

ISRCTN14062994.

The association between inadequate personal protective equipment during the COVID-19 pandemic and an increased risk of SARS-CoV-2 infection in frontline healthcare workers has been proven. However, frontline healthcare workers with an adequate supply of personal protective equipment still showed an increased risk of contracting COVID-19. Research on the use of personal protective equipment could provide insight into handling present and future pandemics.

This study aims to investigate the impact of the availability, training and correct selection of personal protective equipment on the incidence of SARS-CoV-2 infection or positive suspect cases in healthcare workers during the COVID-19 pandemic in Belgium.

This was a prospective cohort study involving Belgian healthcare workers nurses, nursing aides, and midwives working in hospitals, home care services, and residential care services.

Respondents were invited from May to July 2020 (period 1) followed by a second time in October 2020 (period 2) to compl protective equipment knowledge in practitioners. Tweetable abstract Proper training in personal protective equipment usage is critical to reduce the risk of COVID infection in healthcare workers.Transcranial magnetic stimulation (TMS) is a non-invasive form of brain stimulation that makes use of the magnetic field generated when an electric current passes through a magnetic coil placed over the scalp. It can be applied as a single stimulus at a time, in pairs of stimuli, or repetitively in trains of stimuli (repetitive TMS, rTMS). RTMS can induce changes in brain activity, whose after-effects reflect the processes of long-term potentiation and long-term depression, as certain protocols, namely those using low frequencies (≤1 Hz) seem to suppress cortical excitability, while those using high frequencies (>1 Hz) seem to enhance it. It is a technique with very few and mostly mild side-effects, whose effects can persist for long time periods, and as such, it has been studied as a potential treatment option in a multitude of neurodegenerative diseases, including those affecting movement. Although rTMS has received approval as a treatment strategy of only a few aspects in movement disorders in the latest guidelines, its further use seems to also be promising in their context. In this review, we gathered the available literature on the therapeutic application of rTMS in movement disorders, namely Parkinson's disease, Amyotrophic Lateral Sclerosis, Huntington's disease, Dystonia, Tic disorders and Essential Tremor.We aimed to gauge the interstitial lung water accumulation following moderate-intensity exercise under normobaric and hypobaric hypoxic conditions in a group of preterm born but otherwise healthy young adults. Sixteen pre-term-born individuals (age = 21±2yrs.; gestational age = 29±3wk.; birth weight = 1160±273 g) underwent two 8 -h hypoxic/altitude exposures in a cross-over manner 1) Normobaric hypoxic exposure (NH; FIO2 = 0.142±0.001; PIO2  = 90.6±0.9 mmHg) 2) Hypobaric hypoxic exposure (HH; terrestrial high-altitude 3840 m; PIO2  = 90.2±0.5 mmHg). Interstitial lung water was assessed via quantification of B-Lines (using lung ultrasound) before (normoxia) and after 4-h and 8-h of respective exposures. At each time point, B-Lines were quantified before (Pre) and immediately after (Post) a 6-min moderate-intensity exercise. The baseline B-lines count were comparable between both conditions (P = 0.191). A higher B-lines count was noted at Pre-H4 in HH versus NH (P = 0.0420). At Post-H8 B-lines score was significantly higher in HH (4.6 ± 1.6) than in NH (3.1 ± 1.4; P = 0.0073). Furthermore, at this time point, a significantly higher number of individuals with B-line scores ≥5 was observed in HH (n = 7) than in NH (n = 3; P = 0.0420). These findings suggest that short moderate-intensity exercise provokes a significant increase in the interstitial lung water accumulation after 8 h of exposure to terrestrial but not simulated altitude (≈3840 m) in prematurely born adults. Further work is needed to elucidate the exact mechanisms of (moderate-intensity) exercise-induced interstitial lung water accumulation in this population and directly compare the obtained data to full-term born adults.

To better understand genetic determinants of response to ceritinib, an exploratory analysis was conducted using tumor biopsies from anaplastic lymphoma kinase (ALK)-rearranged (ALK+) non-small-cell lung cancer (NSCLC) patients treated with ceritinib at doses of≥300mg in the ASCEND-1 study.

ASCEND-1 was an open-label, multicentre, phase 1, dose-escalation and expansion study of ceritinib (fasted) in ALK inhibitor (ALKi)-naïve or ALKi-pretreated patients with locally advanced or metastatic ALK+NSCLC. Biopsies were assayed by next-generation sequencing (NGS) using a Foundation Medicine panel targeting 295 genes. Somatic alterations were correlated with clinical outcome (cut-off 14-Apr-2014). A total of 285 ALK+NSCLC patients were treated with ceritinib at doses≥300mg.

NGS data were generated for 85 pts (ALKi-pretreated [n=54]; ALKi-naïve [n=31]), 57 were collected from patients before exposure to any ALKi. NGS did not detect ALK rearrangement in 14 of 85 patients; several of these ALK NGS negative cases hacalTrials.gov, NCT01283516. Registered January 26, 2011, https//clinicaltrials.gov/ct2/show/NCT01283516.

ClinicalTrials.gov, NCT01283516. this website Registered January 26, 2011, https//clinicaltrials.gov/ct2/show/NCT01283516.

To evaluate the antibiotic prescription patterns of health workers in Eastern Uganda and more specifically whether they are not in accordance with the Uganda standard treatment guidelines and other indicators of appropriate antimicrobial drug prescription.

Data on variables of the patients was obtained from the health management information system records of the outpatient department registers of Soroti and Mbale Regional Referral Hospitals from 2016 to 2018.

The prevalence of non-adherence to treatment guidelines when prescribing antibiotics was 82.6% (95%CI 81.4% - 83.7%). Guidelines were likely to be adhered to when prescribing antibiotics for individuals aged 13 - 19 years compared to their counterparts aged 0 - 12 years (13 - 19 years adjusted odds ratio (AOR) =0.55, 95%CI 0.40-0.74). When prescribing antibiotics for males, health workers were twice as likely not to adhere to guidelines compared to when prescribing for females (AOR=2.09, 95%CI 1.61-2.72). When prescribing cephalosporins and nitroimars adjusted odds ratio (AOR) =0.55, 95%CI 0.40-0.74). When prescribing antibiotics for males, health workers were twice as likely not to adhere to guidelines compared to when prescribing for females (AOR=2.09, 95%CI 1.61-2.72). When prescribing cephalosporins and nitroimidazoles, health workers were likely not to adhere to guidelines compared to when prescribing penicillin (cephalosporins AOR=1.92, 95%CI 1.28 - 2.86; nitroimidazoles AOR=1.70 95%CI 1.09-2.65). Health workers were most likely not to follow guidelines when prescribing antibiotics in combinations with another antibiotic (2 antibiotics AOR=1.27, 95%CI 1.03 - 1.56) CONCLUSION Non-adherence to treatment guidelines for an indicated diagnosis and inappropriate antibiotic prescription is significantly prevalent in Eastern Uganda. Health workers were more likely not to follow guidelines when prescribing for male patients, children up to 12 years of age and when prescribing cephalosporins, nitroimidazoles or antibiotics in double combination.Tactile interaction between humans and elements in the built environment, such as furniture, is often underappreciated. The aim of this study was to objectively evaluate thermal properties of ten tabletop materials as well as user perceptions of those materials after use. Sixteen participants tested ten materials in a randomised order. Infrared thermography was used to determine tabletop temperature distribution and change. Materials with lower thermal effusivity (wood-based materials) in general reached higher surface temperature differences after 15 min of contact and were rated as more pleasant to touch, more suitable for writing, and more liked for everyday use. Participants' sex and forearm mass had no effect on the temperature after contact. Participants gave the highest ratings to the appearance of oak-based materials. Surface treatment affected subjective evaluation of the materials. The tabletop made of lacquered solid wood had the most favourable thermal and user-rated characteristics.

Hereditary angioedema (HAE) may be caused by a genetic deficiency of functional C1 inhibitor (C1-INH) or linked with mutations in the F12, PLG, and other genes in combination with normal C1-INH (HAEnCI). Although the types of hereditary angioedema due to deficiency of functional C1 inhibitor and HAEnCI are autosomal dominant inherited, there is the impression that in the types of HAEnCI more females carry disease-linked mutations.

The aim of this study was to analyze the passing on of the HAE-specific mutations to the next generations in families with various types of HAE.

Methods comprised pedigree analysis, Sanger sequencing analysis, biochemical analysis of parameters of the kallikrein-kinin system, and statistical analysis of the results. We analyzed a total of 1494 offspring of individuals carrying an HAE-linked mutation.

In HAE, less male and more female offspring of mutation carriers than expected for autosomal dominant inheritance inherited the familial mutation. In addition, there were less male offspring than expected in HAEnCI.