Burtbooker2866
Ionogel electrolytes based on ionic liquids and gelling matrices offer several advantages for solid-state lithium-ion batteries, including nonflammability, wide processing compatibility, and favorable electrochemical and thermal properties. However, the absence of ionic liquids that are concurrently stable at low and high potentials constrains the electrochemical windows of ionogel electrolytes and thus their high-energy-density applications. Here, ionogel electrolytes with a layered heterostructure are introduced, combining high-potential (anodic stability >5 V vs Li/Li+ ) and low-potential (cathodic stability 1 mS cm-1 at room temperature). Using the layered heterostructure ionogel electrolytes, full-cell solid-state lithium-ion batteries with a nickel manganese cobalt oxide cathode and a graphite anode are demonstrated, exhibiting voltages that are unachievable with either the high-potential or low-potential ionic liquid alone. Compared to ionogel electrolytes based on mixed ionic liquids, the layered heterostructure ionogel electrolytes enable higher stability operation of full-cell lithium-ion batteries, resulting in significantly enhanced cycling performance.
Perfectionism is a risk factor for depression, anxiety, and eating disorders, and perfectionism interventions show evidence of the impact on the development and maintenance of these disorders. A systematic review and meta-analysis were conducted of studies using perfectionism interventions that included measures of disordered eating/body image concerns. The primary aim was to investigate the impact on perfectionism and disordered eating/body image concerns, with a secondary aim of examining the impact on depression and anxiety.
The systematic review was conducted using Medline, PsycINFO, and Scopus. Grey literature was sought via ProQuest Dissertations and Theses Global. Effect size estimates for the meta-analysis were calculated using between- and within-group comparisons.
Eight studies were included in the between-group analysis and nine studies for the within-group analysis. Perfectionism interventions were effective in reducing perfectionism and disordered eating with large effect sizes, and in redussed. This report provides important early evidence for the efficacy of perfectionism interventions, however, the limited number of publications in this area, the presence of heterogeneity, and lack of diversity in participant populations limits the generalizability of these findings. Future research is needed to determine whether eating disorder treatments may benefit from the routine inclusion of a perfectionism component.
Apathy after stroke is common and has a negative impact on functional recovery. Neuroimaging correlates of poststroke apathy remain unclear. We aimed to investigate microstructural changes associated with the severity of poststroke apathy symptoms.
We assessed 67 patients with cerebral ischaemia who underwent magnetisation transfer brain imaging 12-15 months after stroke. We used magnetisation transfer ratio (MTR) to represent microstructural integrity. We performed whole-brain voxel-based analysis and subsequent region of interest analysis to investigate the association between MTR and symptoms of poststroke apathy. To assess apathy symptoms, we used clinician-reported version of the Apathy Evaluation Scale.
Voxel-based analysis showed the association between symptoms of apathy and decreased MTR in areas overlapping with structures located in both hemispheres left thalamus, bilateral hippocampus, bilateral fornix/stria terminalis, right amygdala, splenium of the corpus callosum, the retrolenticular part of left internal capsule and left sagittal stratum. In the region of interest analysis, only lower MTR in right fornix/stria terminalis was associated with greater poststroke apathy symptoms in a multivariate logistic model (odds ratio 1.25, 95% CI 1.09-1.46, p=0.003). These associations were independent of depressive symptoms.
Magnetisation transfer brain imaging 12-15 months after stroke revealed changes in microstructural integrity associated with apathy symptoms in brain areas related to processing emotional information and reward valuation.
Magnetisation transfer brain imaging 12-15 months after stroke revealed changes in microstructural integrity associated with apathy symptoms in brain areas related to processing emotional information and reward valuation.Parkinson's disease (PD) impairs various cognitive functions, including time perception. Dysfunctional time perception in PD is poorly understood, and no study has investigated the rehabilitation of time perception in patients with PD. We aimed to induce the recovery of time perception in PD patients and investigated the potential relationship between recovery and cognitive functions/domains other than time perception. Sixty patients with PD (27 females) and 20 healthy controls (10 females) were recruited. The participants underwent a feedback training protocol for 4 weeks to improve the accuracy of subjective spatial distance or time duration using a ruler or stopwatch, respectively. They participated in three tests at weekly intervals, each comprising 10 types of cognitive tasks and assessments. After duration feedback training for 1 month, performance on the Go/No-go task, Stroop task, and impulsivity assessment improved in patients with PD, while no effect was observed after distance feedback training. Additionally, the effect of training on duration production correlated with extended reaction time and improved accuracy in the Go/No-go and Stroop tasks. These findings suggest that time perception is functionally linked to inhibitory systems. If the feedback training protocol can modulate and maintain time perception, it may improve various cognitive/psychiatric functions in patients with PD. It may also be useful in the treatment of diseases other than PD that cause dysfunctions in temporal processing.
To quantify the individual influences of antimicrobial cost, method of administration and drug importance in human medicine on dog-owner antimicrobial preference, and determine knowledge, attitudes and influencers of dog-owners surrounding antimicrobials and antimicrobial stewardship.
Data were collected through an online survey targeting three dog-owner participant groups. These consisted of individuals residing in (1) Canada, (2) USA and (3) any country recruited through an educational social media site. USA and Canadian participants were financially compensated. Conjoint analysis was used to quantify the influence of antimicrobial cost, method of administration and drug importance in human medicine. selleck Descriptive and analytical statistics were used for data evaluation.
A total of 809 surveys were completed. Antimicrobial cost accounted for 47% of dog-owner preferences, followed by method of administration (31%) and drug importance in human medicine (22%). All groups preferred lower cost drugs that were administered once by injection.
