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In this issue, Habbous et al. reported that simultaneously evaluating multiple potential living kidney donors for the same intended recipient, rather than sequentially, is more effective and less expensive. This important study highlighted how quicker living kidney donor evaluations benefit patients and lower costs by reducing time spent on dialysis. Given the backlog precipitated by the coronavirus disease 2019 pandemic, devoting resources to ensure efficient living kidney donor evaluations is a better investment than ever before.Increased plasma concentrations of proprotein convertase subtilisin/kexin type 9 or PCSK9, which reduces hepatic uptake of low-density lipoprotein by downregulation of the low-density lipoprotein receptor, have been reported in nephrotic patients and might contribute to hyperlipidemia in nephrotic syndrome. The results of the study by Molina-Jijon et al. found that renal PCSK9 expression was upregulated in the collecting duct of nephrotic patients and animals, suggesting that the kidney might be a major source for plasma PCSK9 in nephrotic syndrome.The mechanisms sustaining a high level of autophagy in podocytes are not well delineated. Seminal studies had unraveled that the polyamine pathway is involved in the regulation of aging and autophagy. Polyamines (e.g., spermine, spermidine, and putrescine) are ubiquitous molecules essential for the physiological processes, including cell growth, development, and differentiation. Liang et al. examined the role of ornithine decarboxylase, and spermidine synthase, and demonstrated that endogenous spermidine is required to maintain intact podocyte autophagy.Peer reporting interventions (i.e., Positive Peer Reporting and tootling) are commonly used peer-mediated interventions in schools. These interventions involve training students to make reports about peers' prosocial behaviors, whether in oral or written form. Although peer reporting interventions have been included in meta-analyses of group contingencies, this study is the first meta-analytic review of single-case research focusing exclusively on peer reporting interventions. The literature search and application of inclusion criteria yielded 21 studies examining the impact of a peer reporting intervention on student behavior compared to baseline conditions. All studies used single-case experimental designs including at least three demonstrations of an effect and at least three data points per phase. Several aspects of studies, participants, and interventions were coded. Log response ratios and Tau were calculated as effect size estimates. Effect size estimates were synthesized in a multi-level meta-analysis with random effects for (a) studies and (b) cases within studies. Overall results indicated peer reporting interventions had a non-zero and positive impact on student outcomes. Eprosartan price This was also true when data were subset by outcome (i.e., disruptive behavior, academically engaged behavior, and social behavior). Results were suggestive of more between- than within-study variability. Moderator analyses were conducted to identify aspects of studies, participants, or peer reporting interventions associated with differential effectiveness. Moderator analyses suggested published studies were associated with higher effect sizes than unpublished studies (i.e., theses/dissertations). This meta-analysis suggests peer reporting interventions are effective in improving student behavior compared to baseline conditions. Implications and directions for future investigation are discussed.The purpose of this study was to support the development and initial validation of the Intervention Selection Profile (ISP)-Skills, a brief 14-item teacher rating scale intended to inform the selection and delivery of instructional interventions at Tier 2. Teacher participants (n = 196) rated five students from their classroom across four measures (total student n = 877). These measures included the ISP-Skills and three criterion tools Social Skills Improvement System (SSIS), Devereux Student Strengths Assessment (DESSA), and Academic Competence Evaluation Scales (ACES). Diagnostic classification modeling (DCM) suggested an expert-created Q-matrix, which specified relations between ISP-Skills items and hypothesized latent attributes, provided good fit to item data. DCM also indicated ISP-Skills items functioned as intended, with the magnitude of item ratings corresponding to the model-implied probability of attribute mastery. DCM was then used to generate skill profiles for each student, which included scores representing the probability of students mastering each of eight skills. Correlational analyses revealed large convergent relations between ISP-Skills probability scores and theoretically-aligned subscales from the criterion measures. Discriminant validity was not supported, as ISP-Skills scores were also highly related to all other criterion subscales. Receiver operating characteristic (ROC) curve analyses informed the selection of cut scores from each ISP-Skills scale. Review of classification accuracy statistics associated with these cut scores (e.g., sensitivity and specificity) suggested they reliably differentiated students with below average, average, and above average skills. Implications for practice and directions for future research are discussed, including those related to the examination of ISP-Skills treatment utility.Researchers have become interested in the school climate experiences of Black youth given findings of less positive evaluations of school climate in comparison to their other-race peers. School support for cultural pluralism, also referred to as school support for cultural diversity, has been regarded as one aspect of school climate, but is sometimes distinct from Black youth's ratings of general perceptions of school climate. This project sought to understand the relationship between Black students' perceptions of school support for cultural pluralism and perceptions of school climate. Structural equation modeling techniques were used to determine whether previous perceptions of school support for cultural pluralism predicted later perceptions of school climate in a sample of 336 Black adolescents (Mage = 13.74 years). Furthermore, racial identity was explored as the mechanism through which school support for cultural pluralism impacted school climate appraisals, and differences between Black boys (N = 151) and Black girls (N = 185) were tested. Results confirmed that Black youth who rated their school as being supportive of culturally pluralism had more positive ratings of school climate during the following school year after controlling for the previous year's school climate ratings. However, the mediating role of racial identity differed for Black boys and Black girls, underscoring the need for intersectional research for Black youth and the importance of racial identity. We conclude with a discussion regarding the importance of racial/ethnic identity and pluralism within the school context, as well as, the unique role of school psychologists as preventionists and advocates of change within schools.The general benefits of social support are well-documented; however, little is understood about the unique contributions of social support from specific sources, such as parents and peers. In addition, it is unknown whether social support from some sources might buffer against a lack of social support from another source for the outcome of internalizing problems. The current study investigated two research questions (a) What is the association between social support from mothers, fathers, classmates, and close friends and internalizing problems for adolescent boys and girls? and (b) Can social support from one source (e.g., mothers) buffer against internalizing problems when social support from another source (e.g., fathers) may be lacking? Do these associations vary by gender? These research questions were examined with a sample of 364 middle school students (61.3% female). Students completed a series of self-report questionnaires assessing social support and internalizing symptoms. Multiple group structural equation models indicated that social support provided general benefits from all sources for early adolescent boys and girls. Regarding stress-buffering with low support as a stressor, no evidence was found for compensation between mothers and fathers. Mother support compensated for low classmate support for both boys and girls and father support compensated for low classmate support for boys. Classmate support compensated for low close friend support for boys. Implications in the context of the school environment for both boys and girls are discussed.Motivation wields a tangible impact on students' academic functioning. Among the theoretical frameworks used to explain students' motivation to learn, Eccles et al.'s expectancy-value theory (1983) is one of the most influential. It has been used to investigate students' competence- and value-related beliefs and how they are associated with academic-related choices, learning behaviors, and achievement. In the learning context, cost has mostly been discussed under the expectancy-value framework as a sub-dimension of task value and conceptualized as reflecting the negative aspects of task engagement. The issue of cost has recently attracted growing interest among scholars, providing a way to explain the dynamics of student motivation. However, cost is still underexplored in the empirical literature. In the present study, we assessed adolescent students' perceived cost (i.e., effort cost, opportunity cost, ego cost, and emotional cost) of studying math and examined its unique relations with academic motivation and achievement. Across a series of three studies, we found that cost is empirically distinct from the utility, attainment, and interest components of task value and is closely related to students' maladaptive academic outcomes. In particular, cost showed unique associations with adolescent students' test anxiety, disorganization, adoption of avoidance goals, avoidance intentions, and academic achievement. The present study's findings highlight the importance of including cost as a unique construct alongside value to more fully capture students' motivational dynamics in school.Venous thromboembolism (VTE) is a preventable cause of postoperative morbidity and mortality; however, audits suggest that the use of thromboprophylaxis is underused. In this review, we describe our approach to prevention of postoperative VTE and provide guidance on how to formulate an optimal VTE prophylaxis plan. We recommend that all patients undergo thrombosis- and bleeding-risk assessment as part of their preoperative evaluation. The risk of thrombosis can be estimated based on patient- and procedure-specific factors, using validated risk-assessment models such as the Caprini score. There are no validated models to predict perioperative bleeding; however, several risk factors have been proposed. Patients should ambulate early and frequently after surgery. We recommend no additional prophylaxis in patients at very low risk of VTE (Caprini score 0). Patients at low risk of VTE (Caprini 1 to 2) are recommended to receive either mechanical or pharmacological prophylaxis. Patients at moderate (Caprini 3 to 4) to high risk of VTE (Caprini ≥5) are recommended pharmacological prophylaxis either alone or combined with mechanical prophylaxis.