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When there is heat leakage loss in the combined cycle, all the characteristic curves of optimal power versus thermal efficiency are loop-shaped ones, and the heat leakage loss only affects the thermal efficiency of the combined Carnot cycle. Comparing the power output of combined heat engines with four types of working mediums, the two-stage combined Carnot cycle using ideal Fermi-Bose gas as working medium obtains the highest power output.A bra use can reduce physiological and physical functions because of clothing pressure, which can be a problem for new senior women starting to lose physical function. The present study presents a bra top design development method for promoting new senior women's physical activity by identifying problems related to bras' effects on women's health and minimizing clothing pressure. The analysis utilized the 3D scan data of 42 adult women (age range 50s) from the 5th Size Korea Project. Bra top design elements were extracted based on new senior consumers' needs. We developed an average wireframe reflecting the new senior's physical characteristics, and a standard body form was developed through surface modeling. To produce a consumer-oriented bra with a body shaping effect and reduced clothing pressure that would not affect physical activities, a three-dimensional pattern was developed applying an optimal reduction rate of 80%. To verify the bra's adequacy for the body form of new senior women, two market-available bras were selected and fit-compared to the developed product. The developed bra received higher expert appearance evaluation and 3D virtual clothing evaluation scores. This study is significant because by using virtual fitting technology, it provides foundational data to quantify the quality of fashion products.The use of extracellular vesicles as cell-free therapy is a promising approach currently investigated in several disease models. The intrinsic capacity of extracellular vesicles to encapsulate macromolecules within their lipid bilayer membrane-bound lumen is a characteristic exploited in drug delivery to transport active pharmaceutical ingredients. Besides their role as biological nanocarriers, extracellular vesicles have a specific tropism towards target cells, which is a key aspect in precision medicine. However, the little knowledge of the mechanisms governing the release of a cargo macromolecule in recipient cells and the Good Manufacturing Practice (GMP) grade scale-up manufacturing of extracellular vesicles are currently slowing their application as drug delivery nanocarriers. In this review, we summarize, from a cell biologist's perspective, the main evidence supporting the role of extracellular vesicles as promising carriers in drug delivery, and we report five key considerations that merit further investigation before translating Extracellular Vesicles (EVs) to clinical applications.The article presents the results of the experimental validation of the developed static, time and frequency characteristics under interference and longitudinal feed control of a dynamic system in the process of turning axisymmetric parts. The experiments were conducted on a test bench, consisting of a 16B16P center lathe, a measuring system and a PC with a measurement card. The experiments were carried out to verify the assumptions of the baseline model of the turning process. As part of the study, we determined the static characteristics of the machining process, the time characteristics of the object under interference and under longitudinal feed rate control, and the frequency characteristics of the machine tool system under longitudinal feed rate control. During the experiments, we recorded the observed input and output signal curves and the observed characteristics of the interferences acting on the object, as well as the numerical values of the parameters of the equations describing the model, and in particular the gain of the elastic system, which is difficult to determine by analytical methods. The positive results of the experiments confirm the effectiveness of the proposed models and their usefulness for automation of machining processes.Multimedia wireless communications have rapidly developed over the years. Accordingly, an increasing demand for more secured media transmission is required to protect multimedia contents. Image encryption schemes have been proposed over the years, but the most secure and reliable schemes are those based on chaotic maps, due to the intrinsic features in such kinds of multimedia contents regarding the pixels' high correlation and data handling capabilities. The novel proposed encryption algorithm introduced in this article is based on a 3D hopping chaotic map instead of fixed chaotic logistic maps. The non-linearity behavior of the proposed algorithm, in terms of both position permutation and value transformation, results in a more secured encryption algorithm due to its non-convergence, non-periodicity, and sensitivity to the applied initial conditions. Several statistical and analytical tests such as entropy, correlation, key sensitivity, key space, peak signal-to-noise ratio, noise attacks, number of pixels changing rate (NPCR), unified average change intensity randomness (UACI), and others tests were applied to measure the strength of the proposed encryption scheme. The obtained results prove that the proposed scheme is very robust against different cryptography attacks compared to similar encryption schemes.The development of drug-resistant microorganisms has become a critical issue for modern medicine and drug discovery and development with severe socio-economic and ecological implications. Since standard and conventional treatment options are generally inefficient, leading to infection persistence and spreading, novel strategies are fundamentally necessary in order to avoid serious global health problems. In this regard, both metal and metal oxide nanoparticles (NPs) demonstrated increased effectiveness as nanobiocides due to intrinsic antimicrobial properties and as nanocarriers for antimicrobial drugs. Among them, gold, silver, copper, zinc oxide, titanium oxide, magnesium oxide, and iron oxide NPs are the most preferred, owing to their proven antimicrobial mechanisms and bio/cytocompatibility. buy Cyclopamine Furthermore, inorganic NPs can be incorporated or attached to organic/inorganic films, thus broadening their application within implant or catheter coatings and wound dressings. In this context, this paper aims to provide an up-to-date overview of the most recent studies investigating inorganic NPs and their integration into composite films designed for antimicrobial therapies.Among the described druggable vulnerabilities, acting on the DNA repair mechanism has gained momentum, with the approval of PARP inhibitors in several indications, including breast cancer. However, beyond the mere presence of BRCA1/BRCA2 mutations, the identification of additional biomarkers that would help to select tumors with an extreme dependence on DNA repair machinery would help to stratify therapeutic decisions. Gene set enrichment analyses (GSEA) using public datasets evaluating expression values between normal breast tissue and breast cancer identified a set of upregulated genes. Genes included in different pathways, such as ATM/ATR, BARD1, and Fanconi Anemia, which are involved in the DNA damage response, were selected and confirmed using molecular alterations data contained at cBioportal. Nineteen genes from these gene sets were identified to be amplified and upregulated in breast cancer but only five of them NBN, PRKDC, RFWD2, UBE2T, and YWHAZ meet criteria in all breast cancer molecular subtypes. Correlation of the selected genes with prognosis (relapse free survival, RFS, and overall survival, OS) was performed using the KM Plotter Online Tool. In last place, we selected the best signature of genes within this process whose upregulation can be indicative of a more aggressive phenotype and linked with worse outcome. In summary, we identify genomic correlates within DNA damage pathway associated with prognosis in breast cancer.Natisite (Na2TiSiO5) is a layered sodium titanosilicate containing TiO5 square pyramids. The structure evolution of natisite in water and acid solutions is the basis for its potential applications. With Na2SiO3 as the silicon source, natisite with the shape of the square sheet was selectively prepared from the hydrothermal method with 14.3 mol/L NaOH solution at 240 °C. Natisite has 20 Raman active modes and 22 infrared active modes from the first-principles calculations within density functional theory, and the calculated Raman and infrared spectra agree well with the experimental ones. The characteristic Raman peak at 844 cm-1 is caused by the symmetric stretching of the apical Ti-O bond in the TiO5 unit, assigning to A1g and B2g modes. Natisite remains relatively stable in water with a sodium leaching percentage of lower than 6%. When washing with sulfuric acid solutions, the interlayer spacing of natisite is reduced due to the extensive removal of sodium ions, and an intermediate composed of SiO4 and newly formed TiO6 units may be formed. Moreover, after washing with water and acid solutions, 95.5%, 63.4%, and 35.2% of Na, Si, and Ti in natisite can be leached in total, respectively, resulting in the structural disintegration of natisite.Isoprene (C5H8) is a small lipophilic, volatile organic compound (VOC), synthesized in chloroplasts of plants through the photosynthesis-dependent 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway. Isoprene-emitting plants are better protected against thermal and oxidative stresses but only about 20% of the terrestrial plants are able to synthesize isoprene. Many studies have been performed to understand the still elusive isoprene protective mechanism. Isoprene reacts with, and quenches, many harmful reactive oxygen species (ROS) like singlet oxygen (1O2). A role for isoprene as antioxidant, made possible by its reduced state and conjugated double bonds, has been often suggested, and sometimes demonstrated. However, as isoprene is present at very low concentrations compared to other molecules, its antioxidant role is still controversial. Here we review updated evidences on the function(s) of isoprene, and outline contrasting indications on whether isoprene is an antioxidant directly scavenging ROS, or a membrane strengthener, or a modulator of genomic, proteomic and metabolomic profiles (perhaps as a secondary effect of ROS removal) eventually leading to priming of antioxidant plant defenses, or a signal of stress for neighbor plants alike other VOCs, or a hormone-like molecule, controlling the metabolic flux of other hormones made by the MEP pathway, or acting itself as a growth and development hormone.Spinal cord injury (SCI) results in cell death, demyelination, and axonal loss. The spinal cord has a limited ability to regenerate, and current clinical therapies for SCI are not effective in helping promote neurologic recovery. We have developed a novel scaffold biomaterial that is fabricated from the biodegradable hydrogel oligo(poly(ethylene glycol)fumarate) (OPF). We have previously shown that positively charged OPF scaffolds (OPF+) in an open spaced, multichannel design can be loaded with Schwann cells to support axonal generation and functional recovery following SCI. We have now developed a hybrid OPF+ biomaterial that increases the surface area available for cell attachment and that contains an aligned microarchitecture and extracellular matrix (ECM) proteins to better support axonal regeneration. OPF+ was fabricated as 0.08 mm thick sheets containing 100 μm high polymer ridges that self-assemble into a spiral shape when hydrated. Laminin, fibronectin, or collagen I coating promoted neuron attachment and axonal outgrowth on the scaffold surface.