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Taken together, these findings suggested that HuR may alleviate the chemosensitivity of ESCC cells to cisplatin via binding to IFN-β. Therefore, the HuR/IFN-β axis may be a novel biomarker for improving the chemosensitivity of ESCC.Long non-coding RNA brain cytoplasmic RNA 1 (LncRNA BCYRN1) has been proved to participate in the cancer cell metastasis process, including non-small cell lung cancer (NSCLC). However, the underlying molecular mechanisms involved in the BCYRN1-mediated function remain largely unknown. The qRT-PCR analysis was carried out to examine the relative expressions of BCYRN1, microRNA-30b-3p (miR-30b-3p), and Rho-associated coiled-coil protein kinase 1 (ROCK1). ROCK1 protein level was detected via western blot assay. The migrative and invasive abilities of H520 and A549 cells were evaluated via Transwell assay. The relationships between BCYRN1 and miR-30b-3p or ROCK1 and miR-30b-3p were examined by luciferase reporter assay. The expression levels of BCYRN1 and ROCK1 were upregulated in NSCLC tissues and cells, while miR-30b-3p was downregulated. Higher BCYRN1 expression indicated lymph node metastasis and advanced tumor-node-metastasis (TNM) stage of NSCLC patients. Loss of BCYRN1 suppressed cell migration and invasion. More importantly, miR-30b-3p possessed the binding sites with BCYRN1. Besides, BCYRN1 negatively regulated the expression level of miR-30b-3p. Meanwhile, ROCK1 was proven to be directly targeted by miR-30b-3p. In addition, the silencing of miR-30b-3p also weakened the effect of BCYRN1 knockdown on cell migration and invasion. In vivo, BCYRN1 silencing reduced the growth of A549 cells. LncRNA BCYRN1 was involved in the metastasis of NSCLC through modulating the miR-30b-3p/ROCK1 axis.Mobile health, also referred to as mHealth, is defined by the World Health Organization as the delivery of medical practice supported by mobile devices including smartphones, tablets, virtual assistants, and other wireless devices. Systematic reviews and meta-analyses confirm the effectiveness of mHealth tools at improving patient adherence to various self-care activities with downstream beneficial effects on blood pressure control and reduced health services utilization. Yet the clinical application of mHealth to cardiovascular behavioral medicine has been limited. Given high rates of smartphone ownership in the U.S., it is now possible, at least theoretically, to utilize mHealth on both a population-wide and highly personalized basis to prevent, diagnose, treat, and monitor response to therapy for a broad variety of cardiovascular behavioral medicine conditions. In keeping with the theme of this special issue of Health Psychology, we highlight the "4E" barriers of evidence, eminence, electronic health record, and economics that must be addressed to speed adoption of mHealth to promote cardiovascular behavioral medicine and improve health. (PsycInfo Database Record (c) 2022 APA, all rights reserved).The full partnership of clinical health psychology and cardiology optimizes patient-centered care to address the mental and behavioral needs of patients living with heart disease. This scenario is realized as the East Carolina Heart Institute (ECHI) at East Carolina University (ECU) in Greenville, North Caroline with co-location and co-training of psychologists and cardiologists. ECHI provides services to patients across the full disease continuum of cardiovascular disease (CVD), given the higher rates of heart disease in this rural area. The purpose of this article is to describe the cardiovascular behavioral medicine training model for clinical health psychology doctoral students and its adaptation during the coronavirus disease 2019 (COVID-19) era. Through illustrative case examples, we describe the training model before the COVID-19 pandemic, during the transition to telehealth following the onset of the COVID-19 pandemic, and then the entirely telehealth-based service model. We highlight notable strengths and challenges to delivering telehealth care to cardiac patients in a rural setting, while also discussing the health disparities that uniquely occur within this patient population in Eastern North Carolina. This innovative partnership fosters a responsive environment for training and clinical care, where the complex needs of patients with CVD are treated to increase their overall quality of life and well-being. (PsycInfo Database Record (c) 2022 APA, all rights reserved).Can people communicate distinct emotions by touch? Previous studies in the United States have indicated that certain emotions could be perceived above the chance level when an encoder conveys emotions by touching a decoder's arm. However, the perception of emotions from touch has not been investigated in Japan, where it is uncommon to use touch as a method of daily communication. Therefore, we conducted an experiment with Japanese participants, which was nearly identical to previous studies with non-Japanese people. Results indicated that anger, love, and gratitude were categorized above chance, and fear, disgust, surprise, envy, and sympathy could also be accurately recognized above chance at a less detailed level such as pleasant or unpleasant, and aroused or nonaroused. These findings suggest cross-cultural similarities and differences between Japanese and American regarding the perception of emotions by touch. (PsycInfo Database Record (c) 2022 APA, all rights reserved).Military sexual trauma (MST) is prevalent, and some initial evidence suggests it is associated with impaired employment outcomes. The Veterans Health Administration (VHA) offers supported employment (SE) and Community-Based Employment Services (CBES), which consist of individualized employment support integrated with mental health treatment. The objective of this study was to examine the prevalence and effect of MST on competitive employment outcomes following participation in SE or CBES. Participants were a national set of Veterans who participated in VHA SE or CBES services between 2015 and 2019 and whose medical record contained a completed MST screen (N = 12,689). Data were obtained from clinician-administered SE and CBES admission and discharge forms merged with electronic health records. One thousand five hundred fifteen (11.9%) Veterans reported experiencing MST 6.2% (n = 676) of men and 47.8% (n = 839) of women. Veterans who experienced MST were significantly less likely to hold competitive employment at discharge, 568 (41.0%) versus 4,702 (47.4%) of those without MST history; χ² = 19.79, p less then .001. In adjusted analyses, MST was associated with lower likelihood of competitive employment over and above psychiatric comorbidities and other variables associated with employment status, such as receipt of disability, previous unemployment, homelessness, incarceration, and medical comorbidity. Findings suggest that Veterans seeking employment services may represent a high-risk group for having experienced MST and reinforce the importance of trauma-informed care. Providers should assess for and incorporate MST into treatment planning and job development when indicated. More work is needed to inform employment support for Veterans who have experienced MST. (PsycInfo Database Record (c) 2022 APA, all rights reserved).Communities of color have been disproportionately impacted by the coronavirus disease (COVID-19) pandemic, exposing the influence of decades of policies that have under-resourced and marginalized these communities. The history of segregation and inadequate funding in education has been exacerbated by the pandemic, compounding the educational inequities already present in the United States. The intersection of this inequity alongside immigration policies over the past years have led the undocumented student population to be adversely impacted. The lack of access to health care and social safety net programs, fear of deportation, and an over reliance on technology for schooling leaves a large segment of students vulnerable for adverse academic, emotional, and social outcomes. This paper will trace the historical path of educational segregation, immigration policies, and how these led to the disproportionate impact of COVID-19 on undocumented students. It will discuss interventions for undocumented students within an antioppressive ecological framework and the ethical responsibilities that school-based mental health professionals have to support undocumented students to fulfill their highest potential, manage the emotional toll of the pandemic, and advocate for change in immigration and educational policies. Bromopyruvic concentration (PsycInfo Database Record (c) 2022 APA, all rights reserved).Blocking (i.e., reduced responding to cue X following YX-outcome pairings in Phase 2 as a consequence of cue Y having been paired with the outcome in Phase 1) is one of the signature phenomena in Pavlovian conditioning. Its discovery promoted the development of multiple associative models, most of which viewed blocking as an instance of pure cue competition (i.e., a decrease in responding attributable to training two conditioned stimuli in compound). Two experiments are reported in which rats were examined in a fear conditioning paradigm (i.e., lick suppression), and context dependency of retrieval at test was used as an index of associative cue interference (i.e., a decrease in responding to a target cue as a result of training a second cue with the same outcome but without concurrent presentation of the two cues). Specifically, we observed renewal of forward-blocking which parallels renewal of proactive interference, and renewal of backward-blocking which parallels renewal of retroactive interference. Thus, both backward-blocking (Experiment 1, embedded in a sensory preconditioning design) and forward-blocking (Experiment 2, conducted in first-order conditioning) appear to be influenced by retroactive and proactive interference, respectively, as well as cue competition. Consequently, blocking, long regarded as a benchmark example of pure cue competition, is sometimes a hybrid of cue competition and associative interference. Finally, the Discussion considers whether stimulus competition and associative interference are two independent phenomena or products of a single underlying process. (PsycInfo Database Record (c) 2022 APA, all rights reserved).The coronavirus disease (COVID-19) pandemic has negatively impacted the well-being of many college students, particularly lesbian, gay, bisexual, transgender, queer, and questioning (LGBTQ +) students who are already at a disproportionate risk for negative mental health and well-being outcomes. To identify potential risk and protective factors we examined LGBTQ + college students' disclosure of sexual orientation, gender identity, or both (SOGI) to mothers and fathers, living arrangements (whether or not students lived with mothers and fathers), social support from family and friends, and parent-child relationship quality and their association with stress, depressive symptoms, anxiety symptoms, and problem drinking during the pandemic. LGBTQ + college students (N = 366; Mage = 20.4) completed an online survey. Students who reported more social support from family and friends and better quality relationships with mothers or fathers had better well-being and were less likely to perceive a substantial decrease in their well-being due to the pandemic.